A5035158100- Calcium Carbonate Crystallization and Inhibition
- Marine Bivalve and Aquaculture Studies
- Aquaculture disease management and microbiota
- Aquaculture Nutrition and Growth
- MicroRNA in disease regulation
- Invertebrate Immune Response Mechanisms
- Marine Biology and Environmental Chemistry
- Cancer-related molecular mechanisms research
- Bone Tissue Engineering Materials
- Physiological and biochemical adaptations
- Nicotinic Acetylcholine Receptors Study
- Epigenetics and DNA Methylation
- Cholinesterase and Neurodegenerative Diseases
- Circular RNAs in diseases
- Parasites and Host Interactions
- Cancer Cells and Metastasis
- Cancer-related gene regulation
- MXene and MAX Phase Materials
- Heat shock proteins research
- Histone Deacetylase Inhibitors Research
- Parasite Biology and Host Interactions
- Calpain Protease Function and Regulation
- Polyamine Metabolism and Applications
- Antimicrobial Peptides and Activities
- RNA modifications and cancer
Guangdong Ocean University
2016-2025
Xiangya Hospital Central South University
2025
Central South University
2025
Zhanjiang Experimental Station
2015-2022
South China Agricultural University
2018
Yunnan Academy of Forestry
2014
Ningbo University
2014
Sun Yat-sen University
2011-2013
Sun Yat-sen Memorial Hospital
2011-2013
Tumor-initiating cells are resistant to chemotherapy, but how microRNAs play a role in regulating drug resistance of breast tumor-initiating (BT-IC) needs be clarified.
Abstract Nacre, the iridescent material found in pearls and shells of molluscs, is formed through an extraordinary process matrix-assisted biomineralization. Despite recent advances, many aspects biomineralization its evolutionary origin remain unknown. The pearl oyster Pinctada fucata martensii a well-known master biomineralization, but molecular mechanisms that underlie production are not fully understood. We sequenced highly polymorphic genome conducted multi-omic biochemical studies to...
MicroRNAs are involved in regulating the biology of cancer cells, but their involvement chemoresistance is not fully understood. We found that miR-663 was up-regulated our induced multidrug-resistant MDA-MB-231/ADM cell line and this up-regulation closely related to chemosensitivity. In present study, we aimed clarify role breast cancer. MicroRNA microarray quantitative RT-PCR assays were used identify differentially expressed microRNAs. Cell apoptosis evaluated by annexin V/propidium iodide...
Abstract Pearl oysters are found in the marine ecosystem. Due to their frequent exposure microbial pathogens and environmental perturbations, they have developed a multifaceted innate immune system with differentially expressed immune‐related genes response range of stress via vast coordinated reactions, such as recognition, signal transduction, synthesis antimicrobial peptides, encapsulation phagocytosis circulating haemocytes. The species farmed produce pearls. With increasing adoption...
Abstract Background Nicotinic acetylcholine receptors (nAChRs) are among the oldest and most conserved transmembrane involved in signal transduction. Despite prevalence significance of cholinergic signaling, diversity evolution nAChRs not fully understood. Result By comparative genomic analysis, we found massive expansions nAChR genes molluscs some other lophotrochozoans. The expansion is particularly pronounced stationary bivalve with simple nervous systems, number ranging from 99 to 217...
Biomineralization-controlled exo-/endoskeleton growth contributes to body and size diversity. Molluscan shells undergo ectopic biomineralization form the exoskeleton biocalcified "pearl" involved in invading defence. Notably, exo-/endoskeletons have a common ancestral origin, but their regulation are largely unknown. This study employed pearl oyster, Pinctada fucata marntensii, widely used experimental model for invertebrates, perform whole-genome resequencing of 878 individuals from wild...
miR-29a is a conserved miRNA that participates in bone formation and immune response vertebrates. of Pinctada martensii (Pm-miR-29a) was identified the previous research though deep sequencing. In this report, precise sequence mature Pm-miR-29a validated using rapid amplification cDNA ends (miR-RACE) technology. The precursor predicted to have 87 bp. Stem loop qRT-PCR analysis showed easily detected all tissues, although expressions mantle gill were low. microstructure disrupted growth nacre...
Bone morphogenetic protein 7 (BMP7), also called osteogenetic protein-1, can induce bone formation. In this study, the obtained full-length cDNA of BMP7 from Pinctada martensii (Pm-BMP7) was 2972 bp, including a 5'-untranslated region (UTR) 294 an open reading fragment 1290 bp encoding 429 amino acid polypeptide and 3'-UTR 1388 bp. The deduced sequence Pm-BMP7 contained signal peptide, pro-domain mature peptide. peptide consisted 135 acids included transforming growth factor β family domain...
MicroRNAs (miRNAs) are a class of non-coding RNA molecules with presumed post-transcriptional regulatory activity in various biological processes, such as development and biomineralization. Pinctada martensii is one the main species cultured for marine pearl production China Japan. In our previous research, 258 pm-miRNAs had been identified by solexa deep sequencing P. martensii, while it far from number miRNAs found other species. this study, based on transcriptome database sac, we 30...
MicroRNAs (miRNAs) are noncoding RNA molecules that function as negative regulators of target genes. In our previous research, 258 pm-miRNAs were identified in Pinctada martensii by Solexa deep sequencing. Pm-miR-2305 was one the with a potential biomineralization. present study, precursor pm-miR-2305 predicted 96 bp, containing characteristic hairpin structure. Stem-loop qRT-PCR analysis indicated constitutively expressed all tissues (adductor muscle, gill, mantle, hepatopancreas, foot, and...
Marine bivalves undergo complex development processes, such as shell morphology conversion and changes of anatomy life habits. In this study, the transcriptomes pearl oyster Pinctada fucata martensii Pacific Crassostrea gigas at different stages were analyzed to determine key molecular events related formation, settlement metamorphosis.According matrix proteome, biomineralization-related genes exhibited a consensus expression model with critical formation. Differential analysis P. f....