A5032735892- Insect-Plant Interactions and Control
- Calcium Carbonate Crystallization and Inhibition
- Marine Bivalve and Aquaculture Studies
- Marine Biology and Environmental Chemistry
- Aquaculture Nutrition and Growth
- Insect symbiosis and bacterial influences
- Connective Tissue Growth Factor Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Bone Metabolism and Diseases
- Traditional Chinese Medicine Studies
- Bone Tissue Engineering Materials
- Lysosomal Storage Disorders Research
- Parkinson's Disease Mechanisms and Treatments
- Advanced Sensor and Energy Harvesting Materials
- Infective Endocarditis Diagnosis and Management
- Viral Infectious Diseases and Gene Expression in Insects
- Aquatic Invertebrate Ecology and Behavior
- TGF-β signaling in diseases
- Immune cells in cancer
- Extracellular vesicles in disease
- Insect behavior and control techniques
- Neurological Disease Mechanisms and Treatments
- RNA and protein synthesis mechanisms
- Cardiovascular Function and Risk Factors
- Conducting polymers and applications
University of Chinese Academy of Sciences
2022-2024
Beijing Anzhen Hospital
2023-2024
Capital Medical University
2023-2024
Ministry of Education
2024
Institute of Zoology
2023-2024
Chinese Academy of Sciences
2023-2024
Beijing Institute of Water
2024
Center for Excellence in Education
2023
Tianjin Medical University
2023
Institute of Zoology
2022
Abstract Broomcorn millet ( Panicum miliaceum L.) is an orphan crop with the potential to improve cereal production and quality, ensure food security. Here we present genetic variations, population structure diversity of a diverse worldwide collection 516 broomcorn genomes. Population analysis indicated that domesticated originated from its wild progenitor in China. We then constructed graph-based pangenome based on long-read de novo genome assemblies 32 representative accessions. Our...
Cardiac fibrosis is a prevalent pathological process observed in the progression of numerous cardiovascular diseases and associated with an increased risk sudden cardiac death. Although BRD4 inhibitor JQ1 has powerful antifibrosis properties, its clinical application extremely limited due to side effects. There remains unmet need for effective, safe, low-cost treatments. Here, we present multifunctional biomimetic nanoparticle drug delivery system (PM&EM nanoparticles) assembled by platelet...
Structural variation (SV) has an extensive impact on the evolution of genome. The diverse SV provide a material basis for genome evolution, which can affect gene expression, 3D structure, and even changes in complex chromosomal features through regional recombination, copy number variation, chromosome rearrangement. Here, we assemble compare chromosome-level assemblies three species (Acanthoscelides obtectus, Callosobruchus chinensis, C. maculatus) Bruchinae, clade Coleoptera that is often...
Wing dimorphism in insects is an evolutionarily adaptive trait to maximize insect fitness under various environments, by which the population could be balanced between dispersing and reproduction. Most studies concern regulatory mechanisms underlying stimulation of wing morph aphids, but relatively little research addresses molecular basis loss. Here, we found that, while developing normally winged-destined pea disc wingless-destined aphids degenerated 30-hr postbirth that this degeneration...
The ancient crop broomcorn millet (Panicum miliaceum L.) is an indispensable orphan in semi-arid regions due to its short life cycle and excellent abiotic stress tolerance. These advantages make it important alternative increase food security achieve the goal of zero hunger, particularly light uncertainty global climate change. However, functional genomic biotechnological research has been hampered a lack genetic tools such as transformation genome-editing techniques. Here, we successfully...
Bone morphogenetic protein 7 (BMP7), also called osteogenetic protein-1, can induce bone formation. In this study, the obtained full-length cDNA of BMP7 from Pinctada martensii (Pm-BMP7) was 2972 bp, including a 5'-untranslated region (UTR) 294 an open reading fragment 1290 bp encoding 429 amino acid polypeptide and 3'-UTR 1388 bp. The deduced sequence Pm-BMP7 contained signal peptide, pro-domain mature peptide. peptide consisted 135 acids included transforming growth factor β family domain...
Abstract Background Patients with ischemic heart disease (IHD) experience a high incidence of progression to failure (HF) despite current therapies. We speculated that steroid hormone metabolic disorders distinct adverse phenotypes and contribute HF. Methods measured 18 steroids using liquid chromatography tandem mass spectrometry in 2023 patients from the Registry Study Biomarkers Ischemic Heart Disease (BIOMS‐IHD), including 1091 IHD retrospective discovery set 932 multicentre validation...
Marine pearl production is directly influenced by the growth speed of Pinctada fucata martensii. However, slow rate this organism remains main challenge in aquaculture production. Epidermal factor receptor (EGFR), an important tyrosine kinases animals, plays versatile functions development, and tissue regeneration. In study, we described characteristic function EGFR gene identified from P. f. martensii (PmEGFR). PmEGFR possesses a typical structure expressed all studied tissues, with highest...
Pinctada fucata martensii is cultured for pearl production. Growth improvement has received considerable research interest. Transforming growth factor β type Ⅰ receptor (TβR-I), which involved in signals transmission of transforming beta (TGF-β), participates cell proliferation and growth. In this study, we characterized a Tgfbr1 gene encoded TβR-I from P. (Pmtgfbr1). Pmtgfbr1 cDNA contains an open reading frame 1569 bp encodes polypeptide 522 amino acids (aa). possesses typical structure...
Parkinson’s disease (PD) is a nervous disorder, affects physical movement, and leads to difficulty in balancing, walking, coordination. A novel sensor mandatory determine PD monitor the progress of treatment. Neurofilament light chain (NfL) has been recognized as good biomarker for also helps distinguish between atypical syndromes. Immunosensor was generated by current–volt measurement on gap-fingered interdigitated electrode with silicon dioxide surface NfL level. To enhance detection,...
Background ST-segment elevation myocardial infarction (STEMI) patients are at a high residual risk of major adverse cardiovascular events (MACEs) after revascularization. Risk factors modify prognostic in distinct ways different STEMI subpopulations. We developed MACEs prediction model with and examined its performance across subgroups. Methods Machine-learning models based on 63 clinical features were trained who underwent PCI. The best-performing (the iPROMPT score) was further validated...
Abstract BACKGROUND Thoracic aortic dissection (TAD) is a life-threatening vascular disease that requires effective drug treatment to prevent progression and rupture. Because arachidonic acid metabolism involved in inflammation homeostasis, we investigated the roles of metabolites TAD pathogenesis their utility as therapeutic targets. METHODS Serum metabolomics analysis was performed characterize patients mouse model. 12/15-LOX expression profiled tissues Four-week-old male Alox15 knockout...
Abstract Wing dimorphism is an evolutionarily adaptive trait to maximize insect fitness under various environments, by which the population could be balanced between migration and reproduction. Most studies concern regulatory mechanisms underlying stimulation of wing morph in aphids, but relatively little research addresses molecular basis loss. Here, we found that disc wingless-destined pea aphids degenerated 30 h post birth autophagic rather than apoptotic degeneration, whereas...