A5052530555- Immune Cell Function and Interaction
- Atherosclerosis and Cardiovascular Diseases
- Lymphoma Diagnosis and Treatment
- RNA modifications and cancer
- Endoplasmic Reticulum Stress and Disease
- Acute Lymphoblastic Leukemia research
- Aortic aneurysm repair treatments
- Cancer, Lipids, and Metabolism
- Cancer-related molecular mechanisms research
- Folate and B Vitamins Research
- Aquaculture disease management and microbiota
- Immune cells in cancer
- RNA Research and Splicing
- Cancer Immunotherapy and Biomarkers
- Cancer, Hypoxia, and Metabolism
- Galectins and Cancer Biology
- Chronic Myeloid Leukemia Treatments
- Adipose Tissue and Metabolism
- T-cell and Retrovirus Studies
- Peptidase Inhibition and Analysis
- Autophagy in Disease and Therapy
- Cytokine Signaling Pathways and Interactions
- Protein Degradation and Inhibitors
- Gastric Cancer Management and Outcomes
- Diabetes and associated disorders
Foshan University
2018-2025
Peking University
2015-2024
Tsinghua University
2016-2024
Shenzhen Technology University
2020-2024
State Administration of Traditional Chinese Medicine of the People's Republic of China
2011-2024
Air Force Medical University
2013-2024
Xijing Hospital
2013-2024
Chongqing Cancer Hospital
2019-2024
Chongqing University
2019-2024
China Medical University
2013-2024
Tumor-initiating cells are resistant to chemotherapy, but how microRNAs play a role in regulating drug resistance of breast tumor-initiating (BT-IC) needs be clarified.
Six metal−organic coordination polymers, [Cu(bdc)(bimb)]n (H2bdc = 1,4-benzenedicarboxylate; bimb 4,4′-bis(1-imidazolyl)biphenyl) (1), [Cu3(btc)2(bimb)2·(H2O)3]n (H3btc 1,3,5-benzenetricarboxylate) (2), [M3(btc)2(bimb)2·(H2O)4]n (M Mn for 3, Co 4, Cd 5), and [Cd(btcH)(bimb)]n (6) were obtained under hydrothermal conditions characterized structurally. The networks exhibit a variety of topologies: compound 1 exhibits triply interpenetrating three-dimensional (3D) framework with distorted...
Endothelial dysfunction induced by hyperhomocysteinemia (HHcy) plays a critical role in vascular pathology. However, little is known about the of endoplasmic reticulum (ER) redox homeostasis HHcy-induced endothelial dysfunction. Here, we show that Hcy induces ER oxidoreductin-1α (Ero1α) expression with stress and inflammation human umbilical vein cells arteries HHcy mice. upregulates Ero1α promoting binding hypoxia-inducible factor 1α to ERO1A promoter. Notably, rather than other thiol...
Type 2 diabetes is a chronic inflammatory metabolic disease, the key point being insulin resistance. Endoplasmic reticulum (ER) stress plays critical role in pathogenesis of type diabetes. Previously, we found that hyperhomocysteinemia (HHcy) induced resistance adipose tissue. Here, hypothesized HHcy induces ER stress, which turn promotes In present study, direct effect Hcy on was investigated by use primary rat adipocytes vitro and mice with vivo. The mechanism G protein-coupled receptor...
Diabetic foot ulcer (DFU) caused by impaired wound healing is a common vascular complication of diabetes. The current study revealed that plasma levels pigment epithelium–derived factor (PEDF) were elevated in type 2 diabetic patients with DFU and db/db mice. To test whether PEDF contribute to skin wound-healing delay diabetes, endogenous was neutralized an anti-PEDF antibody Our results showed neutralization accelerated healing, increased angiogenesis the skin, improved functions numbers...
Particulate matter with an aerodynamic diameter less than 2.5 μM (PM2.5) is one of the major environmental pollutants in China. In this study, we carried out a metabolomics profile study on PM2.5-induced inflammation. PM2.5 from Beijing, China, was collected and given to rats through intra-tracheal instillation vivo. Acute pulmonary injury were observed by function assessment H.E. staining. The lipid metabolic also altered increased phospholipid sphingolipid metabolites broncho-alveolar...
Gut microbiota and the tumor microenvironment are thought to be critical factors that modulate processes of liver diseases, including hepatocellular carcinoma (HCC). Interleukin-25 (IL-25) promotes type 2 immunity via alternative activation macrophages, is closely associated with inflammation-related even malignancies. However, it not clear which role IL-25 plays in development HCC, whether gut involved. was detected by ELISA, Western blotting (WB), immunohistochemistry. Chemokines were...
The sea bass, Lateolabrax maculatus is commercially farmed in Zhuhai, located the Guangdong Province of China. L. aquaculture have suffered acute death, characterized by ulcerations on body surface, congestion, and hemorrhage internal organs such as liver, kidney, spleen. dominant infecting strain bacteria isolated from kidneys diseased fish was identified Aeromonas veronii (strain 18BJ181). This identification based analysis morphological, physiological, biochemical features, well 16S rRNA...
Phenotypic transition of vascular smooth muscle cells (VSMCs) accounts for the pathogenesis a variety diseases during early stage. Recent studies indicate metabolic reprogramming may be involved in VSMC phenotypic transition. However, definite molecules that link energy metabolism to distinct phenotype remain elusive.A carotid artery injury model was used study postinjury neointima formation as well vivo. RNA-seq analysis, cell migration assay, collagen gel contraction wire myography...
Abstract Hyperhomocysteinemia (HHcy) is a risk factor for chronic kidney diseases (CKDs) that affects about 85% CKD patients. HHcy stimulates B cells to secrete pathological antibodies, although it unknown whether this pathway mediates injury. In HHcy-treated 2-kidney, 1-clip (2K1C) hypertensive murine model, HHcy-activated secreted anti-beta 2 glycoprotein I (β GPI) antibodies deposited in glomerular endothelial (GECs), exacerbating glomerulosclerosis and reducing renal function....
The RNA-binding protein Lin28 is known to promote malignancy by inhibiting the biogenesis of let-7, which functions as a tumor suppressor. However, role Lin28/let-7 axis in epithelial-to-mesenchymal transition (EMT) and stemness breast cancer has not been clearly expatiated. In our previous study, we demonstrated that let-7 regulates self-renewal tumorigenicity stem cells. present was highly expressed mesenchymal (M) type cells (MDA-MB-231 SK-3rd), but it barely detectable epithelial (E)...
Obesity and associated metabolic diseases are characterized by a chronic low-grade inflammatory state with the infiltration of many cells, especially macrophages. Immune molecules, including some cytokines, have close relationship metabolism. Interleukin (IL)-25 is member IL-17 cytokine family that can regulate macrophages alleviate dysfunction; however, its role mechanisms in lipid metabolism remain to be extensively clarified. Human serum liver biopsy specimens, high-fat diet-induced...
Cytotoxic T lymphocyte antigen 4 (CTLA4) exerts inhibitory effects on T-cell activation by competition with CD28. In this study, we investigated the effect of CTLA4-IgG homocysteine (Hcy)-induced and potential signal pathways involved in atherosclerotic formation. The CD28 was significantly amplified Hcy treatment splenic cells hyperhomocysteinaemia (HHcy)-accelerated plaques apolipoprotein E-deficient (apoE–/–) mice. As a major competitor CD28, (abatacept) pretreatment, 100 μg/week, apoE–/–...
Vascular endothelial inflammation, including the expression of intercellular adhesion molecule 1 (ICAM-1), is a key event in vascular diseases. However, mechanisms underlying regulation ICAM-1 are largely unknown.To investigate on by NOP2/Sun domain family, member 2 (NSun2)-mediated mRNA methylation and impact NSun2-ICAM-1 regulatory process inflammation allograft arteriosclerosis.By using vitro, cells, vivo assays, we showed that tRNA methyltransferase NSun2 methylated mRNA. Methylation...
Abstract The overactivation of immune cells plays an important role in the pathogenesis hyperhomocysteinemia (HHcy)-accelerated atherosclerosis. Homocysteine (Hcy) activates B cell proliferation and Ab secretion; however, underlying mechanisms for these effects remain largely unknown. Metabolic reprogramming is critical lymphocyte activation effector function. In this study, we showed that Hcy-activated displayed increase both oxidative phosphorylation glycolysis, with a tendency to shift...
T lymphocyte and macrophage infiltration in the aortic wall is critical for abdominal aneurysm (AAA). However, how lymphocytes interact with macrophages pathogenesis of AAA remains largely uncharacterized. In an elastase-induced murine model, we first found that expression pyruvate kinase muscle isozyme 2 (PKM2), last rate-limiting enzyme glycolysis, was increased infiltrated vascular lesions. lymphocyte-specific PKM2 deficiency mice (LckCrePKM2fl/fl) or intraperitoneal administration...
Tamoxifen resistance remains to be a huge obstacle in the treatment of hormone-dependent breast cancer, and this therefore highlights dire need explore underlying mechanisms. The epithelial-mesenchymal transition (EMT) is molecular process through which an epithelial cell transfers into mesenchymal phenotype. Roles EMT embryo development, cancer invasion metastasis have been extensively reported. Herein, we established tamoxifen-resistant MCF-7/TR cells showed that underwent driven by...