A5068191272- Catalytic C–H Functionalization Methods
- Fluorine in Organic Chemistry
- Asymmetric Synthesis and Catalysis
- Liver Disease Diagnosis and Treatment
- N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
- Cyclopropane Reaction Mechanisms
- Catalytic Cross-Coupling Reactions
- Synthesis and Catalytic Reactions
- Chemical Synthesis and Analysis
- Synthetic Organic Chemistry Methods
- Liver physiology and pathology
- Antimicrobial Peptides and Activities
- GDF15 and Related Biomarkers
- Synthesis of Indole Derivatives
- Nutrition and Health in Aging
- Synthesis and Biological Evaluation
- Hepatitis C virus research
- Fungal Biology and Applications
- Synthesis and Reactions of Organic Compounds
- Circular RNAs in diseases
- ECG Monitoring and Analysis
- Click Chemistry and Applications
- Advanced Breast Cancer Therapies
- Hepatitis B Virus Studies
- Natural product bioactivities and synthesis
Chengdu University of Traditional Chinese Medicine
2016-2025
West China Medical Center of Sichuan University
2021-2025
Stanford University
2025
First Affiliated Hospital of Xinjiang Medical University
2023-2025
Xinjiang Medical University
2023-2025
Peking University
2017-2025
Peking University Cancer Hospital
2025
Sun Yat-sen University
2017-2024
Shaanxi Normal University
2023-2024
Zhejiang Chinese Medical University
2022-2024
Background Mental disorders have a high comorbidity with cardiovascular disease (CVD), but the causality between them has not been fully appreciated. Objective This study aimed to systematically explore bidirectional two broad categories of diseases. Methods We conducted Mendelian randomisation (MR) and multivariable MR (MVMR) analyses evaluate potential causal links 10 mental disorders, use antidepressants 7 CVDs. Findings discovered that major depressive disorder (MDD),...
Abstract Chronic nonalcoholic steatohepatitis (NASH) is a metabolic disorder that often leads to liver fibrosis, condition with limited therapy options. Adiponectin an adipocytokine regulates glucose and lipid metabolism via binding its receptors AdipoR1 AdipoR2, AdipoRs signaling reported enhance fatty acid oxidation uptake. Here, we synthesize report adiponectin-based agonist JT003, which potently improves insulin resistance in high fat diet induced NASH mice suppresses hepatic stellate...
Particulate matter with an aerodynamic diameter less than 2.5 μM (PM2.5) is one of the major environmental pollutants in China. In this study, we carried out a metabolomics profile study on PM2.5-induced inflammation. PM2.5 from Beijing, China, was collected and given to rats through intra-tracheal instillation vivo. Acute pulmonary injury were observed by function assessment H.E. staining. The lipid metabolic also altered increased phospholipid sphingolipid metabolites broncho-alveolar...
Two peripheral functionalized clamp-shaped cobalt porphyrin(2.1.2.1) complexes were synthesized, and their electrocatalytic ORR abilities investigated. The crystal data optical redox properties of them revised by modification. capacities DFT calculations F5PhCo F5NCo suggest superior selectivity for the 4e– pathway. This work further confirms porphyrin are ideal Co–N4 catalysts.
A novel and efficient method for the synthesis of difluoroalkylated benzofuran, benzothiophene, indole derivatives via palladium-catalyzed aryldifluoroalkylation 1,6-enynes with ethyl difluoroiodoacetate arylboronic acids has been established. High reaction efficiency, mild conditions, broad substrate scope, good functional group tolerance are features this protocol. Notablely, resultant products can be smoothly converted into CF2-containing benzofurans, benzothiophenes indoles through an...
Comprehensive Summary Developing electrocatalysts with high activity and selectivity for the oxygen reduction reaction (ORR) is vital to promote performance of next‐generation energy technologies, which depend on efficiency catalytic dioxygen. In structure cytochrome c oxidases (C Os), a histidine imidazole residue binding axial position Fe plays crucial role in facilitating selective O 2 water. Inspired by nature, we herein report synthesis Co III corrole 1 tethered an ligand as well its...
Herein, a palladium-catalyzed general synthetic strategy to access an attractive and decorated set of chiral spiro derivatives benzoxazine compounds is unveiled utilizing vinyl benzoxazinanones reacted with pyrazolone 4,5-diones, which extends the application ketones. This asymmetric catalytic [4+2] cycloaddition reaction demonstrates broad substrate scope functional group tolerance in yields up 76% 96% ee. A facile scale-up straightforward conversion diversely substituted products verify...
Delta 5-3-Ketosteroid isomerase (EC 5.3.3.1) promotes an allylic rearrangement involving intramolecular proton transfer via a dienolic intermediate. This enzyme enhances the catalytic rate by factor of 10(10). Two residues, Tyr-14, general acid that polarizes steroid 3-carbonyl group and facilitates enolization, Asp-38 base abstracts transfers 4 beta-proton to 6 beta-position, contribute 10(4.7) 10(5.6) increase, respectively. A major mechanistic enigma is huge disparity between pKa values...
A highly enantioselective formal [3 + 2] cycloaddition reaction between 3-isothiocyanato oxindoles and alkynyl ketones is reported for the first time. An oxazoline-OH type chiral ligand derived from o-hydroxy-phenylacetic acid employed to generate an effective magnesium catalyst in current cyclization give serials of spirooxindoles with good chemical yields enantioselectivities.
We report the synthesis of a library chiral THIQ-fused spirooxindoles. The most potent compound inhibits Ras-GTP, ultimately leading to mitochondrial apoptosis.
Useful chiral biaryls have been constructed through rhodium and gold complex-catalyzed asymmetric benzannulation strategies.
Our aim was to identify changes in the metabolome dilated cardiomyopathy (DCM) as well construct a metabolic diagnostic model for DCM. We utilized non-targeted metabolomics with cross-sectional cohort of age- and sex-matched DCM patients controls. Metabolomics data were analyzed using orthogonal partial least squares-discriminant analysis (OPLS-DA) pathway analysis. It validated combination transcriptome sequencing from public databases. Machine learning models used diagnosis Using multiple...
Red teaming, the practice of adversarially exposing unexpected or undesired model behaviors, is critical towards improving equity and accuracy large language models, but non-model creator-affiliated red teaming scant in healthcare. We convened teams clinicians, medical engineering students, technical professionals (80 participants total) to stress-test models with real-world clinical cases categorize inappropriate responses along axes safety, privacy, hallucinations/accuracy, bias. Six...
This review article presents a thorough overview of recent advancements in the synthesis 2‐aminoquinolines, vital class N‐heterocyclic aromatic compounds with significant biological and pharmaceutical relevance. It systematically summarizes progress made from early 2019 to end 2024, categorizing synthetic approaches into three main types: cyclization C2‐substituted anilines related compounds, amination nitroxides, 2‐haloquinolines, 2‐quinolones, quinolines, ring‐opening heteroaryl amines...