A5052600624- Sulfur Compounds in Biology
- Mitochondrial Function and Pathology
- Traditional Chinese Medicine Analysis
- Cardiac Fibrosis and Remodeling
- Medicinal Plants and Bioactive Compounds
- Pain Mechanisms and Treatments
- Nitric Oxide and Endothelin Effects
- Adipose Tissue and Metabolism
- Cardiovascular Function and Risk Factors
- Multiple Myeloma Research and Treatments
- Pharmacological Effects of Natural Compounds
- Liver Disease Diagnosis and Treatment
- Cell Adhesion Molecules Research
- MicroRNA in disease regulation
- Metabolomics and Mass Spectrometry Studies
- Genomics, phytochemicals, and oxidative stress
- Alcohol Consumption and Health Effects
- Calcium signaling and nucleotide metabolism
- Metabolism, Diabetes, and Cancer
- Signaling Pathways in Disease
- Inflammasome and immune disorders
- Planarian Biology and Electrostimulation
- Sirtuins and Resveratrol in Medicine
- Biochemical effects in animals
- Eicosanoids and Hypertension Pharmacology
Tongji Hospital
2016-2025
Tongji University
2016-2025
Huashan Hospital
2024-2025
Fudan University
2003-2025
University of Washington
2019-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2024
Huazhong University of Science and Technology
2012-2024
Tang Du Hospital
2023-2024
Air Force Medical University
2010-2024
Beijing University of Chinese Medicine
2018-2024
Salidroside (SDS) is the main effective ingredient of Rhodiola rosea L with a variety pharmacologic properties. We aim to investigate effects SDS on ventilation induced lung injury (VILI) and explore possible underlying molecular mechanism.Lung was in male ICR mice via mechanical (30 ml/kg) for 4h. The were divided four groups:(1) Control group; (2) Ventilation (3) (4) group. (50 mg/kg) injected intraperitoneally 1h before operation. Mouse vascular endothelial cells (MLVECs) subjected cyclic...
Recent reports have suggested that salidroside could protect cardiomyocytes from oxidative injury and stimulate glucose uptake in skeletal muscle cells by activating AMP-activated protein kinase (AMPK). The aim of this study was to evaluate the therapeutic effects on diabetic mice explore underlying mechanisms.The type 2 diabetes were investigated. Increasing doses (25, 50 100 mg·kg(-1) ·day(-1)) administered p.o. db/db for 8 weeks. Biochemical analysis histopathological examinations...
Lipid overload-induced heart dysfunction is characterized by cardiomyocyte death, myocardial remodeling, and compromised contractility, but the impact of excessive lipid supply on cardiac function remains poorly understood.To investigate regulation mitochondrial fission protein Drp1 (dynamin-related 1) in death dysfunction.Mice fed a high-fat diet (HFD) developed signs obesity type II diabetes mellitus, including hyperlipidemia, hyperglycemia, hyperinsulinemia, hypertension. HFD for 18 weeks...
Keloids are complex pathological skin scars characterised by excessive growth of fibrous tissue and abnormal accumulation extracellular matrix (ECM). Despite various treatment options available, the keloids remains a major clinical challenge due to high recurrence rates inconsistent therapeutic outcomes. By collecting three keloid tissues normal samples utilising single-cell RNA sequencing (scRNA-seq), we delved into cellular heterogeneity molecular mechanisms keloids. Our study identified...
AimsAngiotensin II (AngII) is involved in extracellular matrix (ECM) accumulation contributing to heart failure. Periostin, a 90 kDa ECM protein, key regulator of cardiac fibrosis, and its expression significantly higher failing hearts. We determined the modulatory effect AngII on periostin level explored possible signal transduction mechanism.
Body composition and meat quality traits are important economic of chickens. The development high-throughput genotyping platforms relevant statistical methods have enabled genome-wide association studies in In order to identify molecular markers candidate genes associated with body traits, were conducted using the Illumina 60 K SNP Beadchip genotype 724 Beijing-You For each bird, a total 16 measured, including carcass weight (CW), eviscerated (EW), dressing percentage, breast muscle (BrW)...
Background Hydrogen sulfide (H2S), the third physiologically relevant gaseous molecule, is recognized increasingly as an anti-inflammatory mediator in various inflammatory conditions. Herein, we explored effects and mechanisms of sodium hydrosulfide (NaHS, a H2S donor) on tumor necrosis factor (TNF)-α-induced human umbilical vein endothelial cells (HUVEC) dysfunction. Methodology Principal Findings Application NaHS concentration-dependently suppressed TNF-α-induced mRNA proteins expressions...
Our previous studies suggested that salidroside could alleviate hepatic steatosis in type 2 diabetic C57BLKS/Leprdb (db/db) mice. The aim of the present study was to evaluate therapeutic effect on high-fat diet- (HFD-) induced nonalcoholic fatty liver disease (NAFLD) by investigating underlying mechanisms. Mice were fed with HFD or regular diet, randomly divided into two groups, and treated vehicle for 8 weeks. Then, biochemical analyses histopathological examinations conducted vivo vitro....
Abstract Background Mitochondria are dynamic organelles that constantly change their morphology through fission and fusion processes. Recently, abnormally increased mitochondrial has been observed in several types of cancer. However, the functional roles lipid metabolism reprogramming cancer cells remain unclear. This study aimed to explore role hepatocellular carcinoma (HCC) cells. Methods Lipid was determined by evaluating changes expressions core metabolic enzymes intracellular content....
Salt and drought stress has been an important factor limiting agricultural production, SA is phenolic involved in response, but the function of response to dual salt rice not clear. In this study, effects mechanisms exogenous SA-triggered adaptation were investigated by detecting physiological biochemical indexes expression tolerance genes. The results showed that application could significantly increase antioxidant enzyme activities seedlings under stress, thereby reducing contents H2O2 MDA...
Osteoporosis, caused by a relative increase of bone resorption over formation, is characterized decreased mass and strength, resulting in an increased incidence fractures, which often leads to further disability early mortality the elderly due impaired healing ability. The majority therapeutics currently used clinics for treatment osteoporosis are antiresorptive agents that exert their clinical effect decreasing rate resorption. However, strategies solely aimed at antiresorption have limited...