A5048309955- Medicinal Plant Pharmacodynamics Research
- Biological and pharmacological studies of plants
- Alzheimer's disease research and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Phytochemistry and Biological Activities
- Traditional Chinese Medicine Analysis
- Neurological Disease Mechanisms and Treatments
- Sulfur Compounds in Biology
- Sirtuins and Resveratrol in Medicine
- Bone Metabolism and Diseases
- Natural product bioactivities and synthesis
- Ginseng Biological Effects and Applications
- Medicinal Plants and Neuroprotection
- Plant and animal studies
- Tryptophan and brain disorders
- Pharmacological Effects of Natural Compounds
- Cancer-related molecular mechanisms research
- Natural Compounds in Disease Treatment
- Cardiac Fibrosis and Remodeling
- Plant-based Medicinal Research
- Phosphodiesterase function and regulation
- Mast cells and histamine
- Heavy Metal Exposure and Toxicity
- Neurological Disorders and Treatments
- Plant tissue culture and regeneration
Zunyi Medical University
2016-2025
Hainan University
2025
Macau University of Science and Technology
2022-2024
Ministry of Education of the People's Republic of China
2023
Chengdu University of Traditional Chinese Medicine
2022
Fudan University
2010-2016
Minhang District Central Hospital
2016
First People’s Hospital of Zunyi
2016
Affiliated Hospital of Zunyi Medical College
2016
Institute of Biomedical Science
2010
Plant-microbe interactions are pivotal for ecosystem dynamics and sustainable agriculture, influenced by various factors, such as host characteristics, environmental conditions, human activities. Omics technologies, including genomics, transcriptomics, proteomics, metabolomics, have revolutionized our understanding of these interactions. Genomics elucidates key genes, transcriptomics reveals gene expression dynamics, proteomics identifies essential proteins, metabolomics profiles small...
Background Hydrogen sulfide (H2S), the third physiologically relevant gaseous molecule, is recognized increasingly as an anti-inflammatory mediator in various inflammatory conditions. Herein, we explored effects and mechanisms of sodium hydrosulfide (NaHS, a H2S donor) on tumor necrosis factor (TNF)-α-induced human umbilical vein endothelial cells (HUVEC) dysfunction. Methodology Principal Findings Application NaHS concentration-dependently suppressed TNF-α-induced mRNA proteins expressions...
Phosphodiesterase-5 (PDE5) inhibitors are predominantly used in the treatment of erectile dysfunction, and have been recently shown to a potential therapeutic effect for Alzheimer's disease (AD) through stimulation nitric oxide (NO)/cyclic guanosine monophosphate (cGMP) signalling by elevating cGMP, which is secondary messenger involved processes neuroplasticity. In present study, effects PDE5 inhibitor, icarrin (ICA), on learning memory as well pathological features APP/PS1 transgenic AD...
Inflammation in central nervous system (CNS) plays a vital role neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's (PD), Lewy body dementia (DLB), HIV-related and traumatic brain injury. Icariside II (ICS II), an active flavonoid compound derived from Chinese herbal medicine Epimedium brevicornum Maxim, has been shown to possess neuroprotective effect on AD model. However, whether ICS directly protective acute neuroinflammation remains still unclear. Therefore, the...
Aims: Neuroinflammation and oxidative stress are deemed the prime causes of brain injury after cerebral ischemia/reperfusion (I/R). Since silent mating-type information regulation 2 homologue 3 (Sirt3) pathway plays an imperative role in protecting against neuroinflammation stress, it has been verified as a target to treat ischemia stroke. Therefore, we attempted seek novel Sirt3 agonist explore its underlying mechanism for stroke treatment both vivo vitro. Results: Trilobatin (TLB) not only...
Background and Purpose Astrocytic nuclear factor erythroid‐derived 2‐related 2 (Nrf2) is a potential therapeutic target of ischaemic preconditioning (IPC). Icariside II (ICS II) naturally occurring flavonoid derived from Herba Epimedii with Nrf2 induction potency. This study was designed to clarify if exposure ICS mimicks IPC neuroprotection astrocytes contributes against stroke. Experimental Approach Mice transient middle cerebral artery occlusion (MCAO)‐induced focal ischaemia primary...
Dendrobine, a valuable alkaloid found in
Summary Aims Axonal degeneration is a pathological symbol in the early stage of Alzheimer's disease ( AD ), which can be triggered by amyloid‐β (Aβ) peptide deposition. Growing evidence indicates that deficit autophagy eventually leads to axonal degeneration. Our previous studies have shown Dendrobium nobile Lindl alkaloid DNLA ) had protective effect on neuron impairment vivo and vitro; however, underlying mechanisms still unclear. Methods We exposed cultured hippocampus neurons Aβ 25‐35...
Oxidative stress-induced neuronal cell damage is a crucial factor in the pathogenesis of mitochondria-associated neurological diseases. Therefore, elimination overproduction mitochondrial ROS (mtROS) may be potential strategy for prevention and treatment In present study, neuroprotective effects trilobatin (TLB), novel small molecule monomer derived from Lithocarpus polystachyus Rehd, its underlying mechanisms were investigated vitro using hydrogen peroxide (H2O2)-induced oxidative stress...
Gastrodin (GAS), which is extracted from the Chinese herbal medicine Gastrodia elata Blume, has long been used to improve stroke, epilepsy, dizziness and dementia. However, effects underlying mechanisms of GAS on subacute phase cerebral ischemia‑reperfusion (I/R) injury remain unknown. The aim present study was investigate I/R in rats. rats were pretreated with by gavage for 7 days followed surgery, then treated after surgery. Neurological deficits assessed 1, 3 post‑cerebral injury....
Cerebral ischaemia/reperfusion causes exacerbated neuronal damage involving excessive autophagy and loss. The present study was designed to investigate the effect of icariside II, one main active ingredients Herba Epimedii on this loss whether is related its PDE 5 inhibitory action.Focal cerebral ischaemia induced in rat by transient middle artery occlusion over 2 hr, followed reperfusion with 3-methylamphetamine or rapamycin. II determined measuring behaviour changes size infarction....