A5059259972- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Cancer Immunotherapy and Biomarkers
- Single-cell and spatial transcriptomics
- Cancer Genomics and Diagnostics
- Cancer-related molecular mechanisms research
- Mental Health via Writing
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- Dermatologic Treatments and Research
- Immunotherapy and Immune Responses
- Digital Mental Health Interventions
- Mental Health Research Topics
- Cancer, Hypoxia, and Metabolism
- Vibration Control and Rheological Fluids
- Pancreatic and Hepatic Oncology Research
- Immune cells in cancer
- Innovative Energy Harvesting Technologies
- Machine Learning in Healthcare
- Computational Drug Discovery Methods
- Immune Cell Function and Interaction
- Drug Transport and Resistance Mechanisms
- Microbial Applications in Construction Materials
- Ubiquitin and proteasome pathways
- Cutaneous Melanoma Detection and Management
Nanjing Medical University
2021-2025
Central South University
2023-2025
Xiangya Hospital Central South University
2023-2025
Southwest Petroleum University
2024-2025
Plastic Surgery Hospital
2022-2025
Northwestern Polytechnical University
2022-2025
Southern Medical University Shenzhen Hospital
2025
Jiangsu Province Hospital
2021-2024
Research & Development Institute
2024
University of Michigan
2021-2023
Background Glutamine metabolism (GM) is known to play a critical role in cancer development, including lung adenocarcinoma (LUAD), although the exact contribution of GM LUAD remains incompletely understood. In this study, we aimed discover new targets for treatment patients by using machine learning algorithms establish prognostic models based on GM-related genes (GMRGs). Methods We used AUCell and WGCNA algorithms, along with single-cell bulk RNA-seq data, identify most prominent GMRGs...
To address the substantial variability in immune checkpoint blockade (ICB) therapy effectiveness, we developed an innovative R package called integrated Machine Learning and Genetic Algorithm-driven Multiomics analysis (iMLGAM), which establishes a comprehensive scoring system for predicting treatment outcomes through advanced multi-omics data integration. Our research demonstrates that iMLGAM scores exhibit superior predictive performance across independent cohorts, with lower correlating...
Uveal melanoma(UVM) is the most common intraocular malignancy and has a poor prognosis. The clinical significance of necroptosis(NCPS) in UVM unclear.
Hepatocellular carcinoma (HCC) is one of the most common cancers in world and often associated with a poor prognosis. The main reason for this prognosis that inconspicuous early symptoms lead to delayed diagnosis. Treatment options advanced HCC remain limited ineffective. In context, exploration immune microenvironment becomes attractive. study, we divided into cell non-immune subtypes, by single-cell sequencing analysis GEO dataset GSE146115. We found differentially expressed genes two...
Mast cells, comprising a crucial component of the tumor immune milieu, modulate neoplastic progression by secreting an array pro- and antitumorigenic factors. Numerous extant studies have produced conflicting conclusions regarding impact mast cells on prognosis patients afflicted with lung adenocarcinoma (LUAD).Employing single-cell RNA sequencing (scRNA-seq) analysis, cell-specific marker genes in LUAD were ascertained. Subsequently, cell-related (MRGs) signature was devised to stratify...
RPS6KA1 express disorder is associated with many cancers, but the role in head and neck squamous cell carcinoma (HNSCC) specific mechanism still unclear. We used bioinformatics analysis to explore of Ribosomal Protein S6 Kinase A1(RPS6KA1) HNSCC which were predicted regulate certain pathway immune microenvironment increase risk HNSCC. Multiple tools based on EBI, GEO, TCGA databases clinical samples analyze expression RPS6K1 Western blot (WB) PCR results confirmed upregulation tissues. Flow...
Keloids are complex pathological skin scars characterised by excessive growth of fibrous tissue and abnormal accumulation extracellular matrix (ECM). Despite various treatment options available, the keloids remains a major clinical challenge due to high recurrence rates inconsistent therapeutic outcomes. By collecting three keloid tissues normal samples utilising single-cell RNA sequencing (scRNA-seq), we delved into cellular heterogeneity molecular mechanisms keloids. Our study identified...
To construct a prognosis model of melanoma based on pyroptosis related genes.Melanoma RNA-sequencing data was downloaded from TCGA. First, the lnRNAs to were obtained through Pearson correlation analysis. Then, genes constructed by Cox regression and Lasso regression. Melanoma patients divided into high-risk low-risk groups risk score, differences in immune microenvironment between two explored.We found that group had significantly poorer prognosis, different differed infiltration, m6A...
Background As a tumor type with high mortality and poor therapeutic effect, the pathogenesis of pancreatic cancer is still unclear. It necessary to explore significance necroptosis in cancer. Methods Pancreatic transcriptome data were obtained from TCGA database, ICGC GSE85916 GEO database. The cohort was set as training cohort, while validation cohorts. Single-cell sequencing GSE154778 genes most associated identified by weighted co-expression network analysis single-cell analysis. COX...
It has been suggested that lactate metabolism (LM) is crucial for the development of cancer. Using integrated single-cell RNA sequencing (scRNA-seq) analysis, we built predictive models based on LM-related genes (LMRGs) to propose novel targets treatment LUAD patients.The most significant LM were identified through use AUCell algorithm and correlation analysis in conjunction with scRNA-seq analysis. To build risk superior performance, cox- lasso-regression utilized, these validated multiple...
The phenomenon of T Cell exhaustion (TEX) entails a progressive deterioration in the functionality cells within immune system during prolonged conflicts with chronic infections or tumors. In context ovarian cancer immunotherapy, development, and outcome treatment are closely linked to T-cell exhaustion. Hence, gaining an in-depth understanding features TEX microenvironment is paramount importance for management OC patients. To this end, we leveraged single-cell RNA data from perform...
Glioblastoma (GBM) is a malignant primary brain tumor. This study focused on exploring the exosome-related features of glioblastoma to better understand its cellular composition and molecular characteristics.Single-cell RNA sequencing (scRNA-seq) spatial transcriptome (stRNA-seq) were used analyze heterogeneity glioblastomas. After data integration, cell clustering, annotation, five algorithms calculate scores for genes(ERGs). Cell trajectory analysis intercellular communication performed...
Microbially induced calcium carbonate precipitation (MICP) is an environmentally friendly technology that improves soil permeability resistance through biocementation. In this study, 2D microscopic analysis and 3D volume reconstruction were performed on river sand after 24 cycles of bio-treatment based stacked images computed tomography (CT) scanning data, respectively, to extract biocementation patterns between particles. Based the mutual validation findings two techniques, three in...
Liver cancer is the fifth most common type of worldwide, and ATP-binding cassette (ABC) transporter family has been widely accepted as a cause multidrug resistance. This study was conducted to explore potential value mechanisms ABC gene in liver hepatocellular carcinoma (LIHC).Data were collected from different public databases. UALCAN, ONCOMINE, GEPIA used retrieve selection differently expressed pathological stage-related genes among family. Principal component analysis (PCA) utilized for...
Background The pathophysiology of keloid formation is not yet understood, so the identification biomarkers for kelod can be one step towards designing new targeting therapies which will improve outcomes patients with keloids or at risk developing keloids. Methods In this study, we performed single-cell RNA sequencing analysis, weighted co-expression network and differential expression analysis based on public databases. And 3 data from in our center were used validation. Besides, QRT-PCR...
Preeclampsia (PE) is associated with maternal and fetal perinatal morbidity mortality, which brings tremendous suffering imposes an economic burden worldwide. The failure of uterine spiral artery remodeling may be related to the abnormal function trophoblasts lead occurrence progression PE. Aberrant expression long non-coding RNAs (lncRNAs) involved in remodeling. However, regulation lncRNA PE poorly characterized. Here, we reported that hypoxia-induced microRNA (miR)-218 inhibited TUG1 by...
Autophagy inhibits tumorigenesis by limiting inflammation. Various lncRNAs are associated with tumour biological processes, including lung adenocarcinoma (LUAD), but the role of autophagy-related (ARlncRNAs) in LUAD has not been fully elucidated. Thus, this study aimed to construct a prognostic signature based on ARlncRNAs for LUAD.The RNA-seq (FPKM) data and clinical information patients were downloaded from The Cancer Genome Atlas (TCGA) database. After differentially expressed normal...
Abstract Cutaneous melanoma poses a formidable challenge within the field of oncology, marked by its aggressive nature and capacity for metastasis. Despite extensive research uncovering numerous genetic molecular contributors to cutaneous development, there remains critical knowledge gap concerning role lipids, notably low‐density lipoprotein (LDL), in this lethal skin cancer. This article endeavours bridge delving into intricate interplay between LDL metabolism melanoma, shedding light on...
Colorectal cancer is a malignant tumor of the digestive system originating from abnormal cell proliferation in colon or rectum, often leading to gastrointestinal symptoms and severe health issues. Nucleotide metabolism, which encompasses synthesis DNA RNA, pivotal cellular biochemical process that significantly impacts both progression therapeutic strategies colorectal METHODS: For single-cell RNA sequencing (scRNA-seq), five functions were employed calculate scores related nucleotide...
Anoikis is a specialized form of programmed cell death induced by the loss adhesion to extracellular matrix (ECM). Acquisition anoikis resistance significant marker for cancer invasion, metastasis, therapy resistance, and recurrence. Although current research has identified multiple factors that regulate pathological mechanisms anoikis-mediated tumor microenvironment (TME) in glioblastoma (GBM) remain largely unexplored.
Recent years have seen increased worldwide popularity of e-cigarette use. However, the risks e-cigarettes are underexamined. Most adverse event studies achieved low detection rates due to limited subject sample sizes in experiments and surveys. Social media provides a large data repository consumers' feedback experiences, which useful for safety surveillance. it is difficult automatically interpret informal nontechnical consumer vocabulary about social media. This issue hinders use content...
Cancer is one of the serious diseases that endanger human health and bring a heavy burden to world economic development. Although current targeted therapy immunotherapy have achieved initial results, emergence drug resistance shows existing research far from enough. In recent years, tumor microenvironment has been found be an important condition for development profound value. The SLC16 family group monocarboxylic acid transporters involved in cancer metabolism formation microenvironment....