A5100599689- Cancer, Hypoxia, and Metabolism
- Mitochondrial Function and Pathology
- ATP Synthase and ATPases Research
- Cancer, Lipids, and Metabolism
- Peroxisome Proliferator-Activated Receptors
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- interferon and immune responses
- MicroRNA in disease regulation
- Lipid metabolism and biosynthesis
- Receptor Mechanisms and Signaling
- Cancer-related gene regulation
- Ubiquitin and proteasome pathways
- Diet and metabolism studies
- Mast cells and histamine
- Circadian rhythm and melatonin
- Adenosine and Purinergic Signaling
- Signaling Pathways in Disease
- Autophagy in Disease and Therapy
- Circular RNAs in diseases
- Pancreatic function and diabetes
- Spaceflight effects on biology
- Genomics, phytochemicals, and oxidative stress
- GDF15 and Related Biomarkers
- RNA regulation and disease
Air Force Medical University
2014-2025
Shandong University
2023
Chongqing Medical University
2014-2023
Chongqing Public Health Medical Center
2014-2023
Liaoning Cancer Hospital & Institute
2018-2022
China Medical University
2018-2022
State Key Laboratory of Cancer Biology
2021
Hunan Normal University
2021
Hunan Provincial People's Hospital
2021
Mitochondrial morphology is dynamically remodeled by fusion and fission in cells, dysregulation of this process closely implicated tumorigenesis. However, the mechanism which mitochondrial dynamics influence cancer cell survival considerably less clear, especially hepatocellular carcinoma (HCC). In study, we systematically investigated alteration its functional role regulation autophagy HCC survival. Furthermore, underlying molecular mechanisms therapeutic application were explored depth....
Salt-inducible kinase 2 (SIK2) has been established as a regulator of diverse biological processes including cell metabolism. A recent study reported that SIK2 is required for adipocyte-induced ovarian cancer (OC) survival through facilitating fatty acid oxidation. However, whether also plays role in the lipid synthesis OC cells remains elusive. Here, we showed significantly promoted cells. On one hand, enhanced upregulating expression sterol regulatory element binding protein 1c (SREBP1c)...
Abstract Background Mitochondria are dynamic organelles that constantly change their morphology through fission and fusion processes. Recently, abnormally increased mitochondrial has been observed in several types of cancer. However, the functional roles lipid metabolism reprogramming cancer cells remain unclear. This study aimed to explore role hepatocellular carcinoma (HCC) cells. Methods Lipid was determined by evaluating changes expressions core metabolic enzymes intracellular content....
Abstract Background & Aims Mitochondrial dynamics of fission and fusion plays critical roles in a diverse range important cellular functions, its deregulation has been increasingly implicated human diseases. Previous studies have shown that increased mitochondrial significantly promoted the proliferation hepatocellular carcinoma (HCC) cells. However, how they influence migration tumour cells remained largely unknown. Methods In present study, we further investigated effect on metastasis...
Abstract Emerging evidences show that disruption of the circadian rhythm is associated with tumor initiation and progression. Neuronal PAS domain protein 2 (NPAS2), one core molecules, has been proved to be a potential prognostic biomarker in colorectal breast cancers. However, date, functional roles molecular mechanisms by which NPAS2 affects cancer cell survival are greatly unclear, especially hepatocellular carcinoma (HCC). We first investigated expression its clinical significance HCC....
Levels of the mitochondrial calcium uniporter regulator 1 (MCUR1) increases during development hepatocellular carcinoma (HCC). However, mechanisms how Ca2+ homeostasis is modulated and its function remain limited in cancers.MCUR1 was frequently upregulated HCC cells to enhance uptake into mitochondria an MCU-dependent manner, which significantly facilitated cell survival by inhibiting mitochondria-dependent intrinsic apoptosis promoting proliferation cells, thus led poor prognosis. In vivo...
Abstract H1 histamine receptor (H1HR) belongs to the family of rhodopsin-like G-protein-coupled receptors. Recent studies have shown that H1HR expression is increased in several types cancer. However, its functional roles tumor progression remain largely unknown, especially hepatocellular carcinoma (HCC). We found frequently unregulated HCC, which significantly associated with both recurrence-free survival and overall HCC patients. Functional experiments revealed promoted growth metastasis...
Abstract Mitochondrial‐nuclear communication plays a vital role in maintaining cellular homeostasis. MOTS‐c, short peptide derived from the 12S rRNA of mitochondrial DNA, has been suggested as retrograde signal. Although recent clinical studies have possible link between MOTS‐c and human cancer, tumorigenesis yet to be investigated. Here, levels are found reduced both serum tumor tissues ovarian cancer (OC) patients, which associated with poor patients’ prognosis. Exogenous inhibits...
Abstract Accumulating evidence has shown that the dysfunction of mitochondria, multifunctional organelles in various cellular processes, is a pivotal event development diseases, including human cancers. Solute Carrier Family 25 Member 42 (SLC25A42) mitochondrial protein governing transport coenzyme A (CoA). However, biological roles SLC25A42 cancers are still unexplored. Here we uncovered upregulated and correlated with worse prognosis GC patients. promotes proliferation gastric cancer (GC)...
Emerging evidence has shown that circular RNAs (circRNAs) serve as a promising biomarker in different malignancies. Specifically, circ_001569 been found to be upregulated some types of human gastrointestinal cancer. In this study, we aimed investigate clinical significances, diagnostic and prognostic values pancreatic cancer (PC), identify its effects on the malignant behaviors PC cells. The expression was determined 26 tissues samples 97 plasma from patients by qRT-PCR. Relationship between...
Abstract Solute carrier family 25 member 20 (SLC25A20) is a mitochondrial-membrane–carrier protein involved in the transport of acylcarnitines into mitochondrial matrix for oxidation. A previous-integrated-proteogenomic study had identified SLC25A20 as one top-three prognostic biomarkers HCC. However, expression and biological function have not yet been investigated In present study, we found that frequently down-regulated HCC cells mainly due to up-regulation miR-132-3p. Down-regulation...
// Xianli He 1, * , Falin Qu 2, Feng Zhou 1 Xingchun 2 Yibing Chen Xu Guo Jibin Li Qichao Huang Yefa Yang 3 Zhuomin Lyu 4 Hongxin Zhang Jinliang Xing Department of General Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an 710032, China State Key Laboratory Cancer Biology and Experimental Teaching Center Basic Medicine, Radioactive Intervention, Eastern Hepatobiliary Surgery Second Shanghai 200438, Pain Treatment, These authors have contributed equally to this work...
Histamine receptor H3 (HRH3) is mainly expressed in the central nervous system, where it involved regulation of release various neurotransmitters brain. Recent studies have demonstrated that expression HRH3 upregulated several types cancer. However, functional effect on tumor progression remains largely unknown, particularly hepatocellular carcinoma (HCC). In present study, 96 HCC patients was first evaluated, and its clinical significance analyzed. Subsequently, roles growth metastasis were...
Abstract Background & Aims Human TFB2M (mitochondrial transcription factor B2) is a key regulator of mitochondria transcription. Our bioinformatic analysis based on the cancer genome atlas (TCGA) data revealed an aberrant over‐expression in hepatocellular carcinoma (HCC). However, functional roles tumourigenesis remains unexplored, including HCC. Methods The expression and clinical significance were evaluated by qRT‐PCR western blot analysis. biological effects underlying mechanisms HCC...