A5101973906- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Cancer, Lipids, and Metabolism
- Nanoplatforms for cancer theranostics
- Cancer Genomics and Diagnostics
- Particle physics theoretical and experimental studies
- Epigenetics and DNA Methylation
- Pancreatic and Hepatic Oncology Research
- Molecular Biology Techniques and Applications
- Photodynamic Therapy Research Studies
- Ubiquitin and proteasome pathways
- Peptidase Inhibition and Analysis
- Cancer Research and Treatments
- Extracellular vesicles in disease
- Dark Matter and Cosmic Phenomena
- Proteoglycans and glycosaminoglycans research
- interferon and immune responses
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cosmology and Gravitation Theories
- Medicinal Plant Pharmacodynamics Research
- Wnt/β-catenin signaling in development and cancer
- Liver Disease Diagnosis and Treatment
- Reproductive Biology and Fertility
Shanghai Jiao Tong University
2025
Binzhou University
2021-2025
Binzhou Medical University
2021-2025
Ministry of Agriculture and Rural Affairs
2025
Yangzhou University
2024-2025
Hunan Normal University
2017-2024
Hunan Provincial People's Hospital
2016-2024
Second Xiangya Hospital of Central South University
2023
Central South University
2023
Minhang District Central Hospital
2022
Axionlike particles (ALPs) and dark photons (DPs) are viable matter particle candidates. We have searched for possible ALP/DP signals in the PandaX-4T liquid xenon detector using 440 kg·yr of data. A binned likelihood fit is constructed to search mono-energetic peaks induced by absorption processes between ALPs/DPs atomic electrons xenon. detailed temporal model decays associated with isotopes introduced constrain number background events. No signal excess over expectations observed, we...
Abstract Background Aberrant DNA methylation may offer opportunities in revolutionizing cancer screening and diagnosis. We sought to identify a non-invasive methylation-based approach using cell-free (cfDNA) for early detection of hepatocellular carcinoma (HCC). Methods Differentially, blocks were determined by comparing profiles biopsy-proven HCC, liver cirrhosis, normal tissue samples with high throughput bisulfite sequencing. A multi-layer HCC model was subsequently constructed based on...
Studies have demonstrated significant alterations in ovarian oxidative stress levels, degeneration, and follicular atresia during the broody period geese. The results of this study showed that period, geese exhibited degraded tissues, disrupted development, a thinner granulosa cell layer, lower levels hormones E2, P4, AMH. Antioxidant activity (GSH, CAT, SOD, T-AOC, content H2O2) mRNA expression antioxidant genes (GPX, SOD-1, SOD-2, COX-2, Hsp70) were significantly higher pre-broody compared...
Emerging evidence has shown that circular RNAs (circRNAs) serve as a promising biomarker in different malignancies. Specifically, circ_001569 been found to be upregulated some types of human gastrointestinal cancer. In this study, we aimed investigate clinical significances, diagnostic and prognostic values pancreatic cancer (PC), identify its effects on the malignant behaviors PC cells. The expression was determined 26 tissues samples 97 plasma from patients by qRT-PCR. Relationship between...
Background: Laparoscopic anatomical liver resection of segment 8 (LALR-S8) remains a challenge for laparoscopic segmentectomy. Most current reports on LALR-S8 are case series using one surgical approach, and there is lack multicenter data identifying intersegmental planes different approaches. In this study, we aimed to elucidate the short-term results three approaches hepatocellular carcinoma (HCC), focusing plane determination, reflect practice regarding at multiple centers in China....
Long non-coding RNAs (lncRNAs) are emerging as important modulators of cancer progression, among which prostate cancer-associated transcript 1 (PCAT1) has been shown to be an oncogene in several tumors. However, the clinical significance and biological function PCAT1 endometrial carcinoma (EC) remain unclear. In this study, we used 89 EC tissues HEC-1B, Ishikawa, RL95-2 AN3CA cell lines. We found elevated expression levels lines using reverse transcription qPCR (RT-qPCR). The prognostic...
Long noncoding RNAs (lncRNAs) play a critical role in the development of lung carcinoma. The mechanism MALAT1 carcinoma is not understood very well. This study aimed to investigate progression and underlying miR-491-5p mediated regulation UBE2C expression. results indicated that expression was often augmented cells. Suppression blocked proliferation, invasion migration ability cancer cells inhibited UBE2C. restoration attenuated knockdown-induced anti-cancer effects. Moreover, were as...
It has been reported that hsa‑microRNA (miRNA/miR)‑372 functions as a tumor suppressor or oncogene in various digestive system tumors, however, its roles gallbladder cancer (GBC) are yet to be established. The present study aimed determine the expression and clinical relevance of hsa‑miR‑372 GBC. 80 pairs human GBC tissues adjacent normal was measured by reverse transcription‑quantitative polymerase chain reaction. Subsequently, associations between levels clinicopathological characteristics...
Background . Long noncoding RNAs (lncRNAs) have been known to play important roles in the progression of various types human cancer. LncRNA GATA3 antisense RNA 1, GATA3-AS1, has reported be associated with T-cell development and differentiation. However, expression pattern function GATA3-AS1 hepatocellular carcinoma (HCC) remain unknown. Methods Real-time quantitative PCR (RT-qPCR) assay was conducted detect levels 80 cases pairs HCC tissues matched normal tissues. Chi-squared ( χ 2 ) test...
Long noncoding RNAs (lncRNAs) represent promising therapeutic targets associated with hepatocellular carcinoma (HCC). lncRNA VPS9D1 antisense RNA 1 (VPS9D1-AS1) regulates colon and prostate cancer, but its relevance in HCC remains to be clarified. Using microarray data from the NCBI Gene Expression Omnibus (GEO) database (GSE65485) The Cancer Genome Atlas (TCGA) database, VPS9D1-AS1 expression normal liver tissue sample were compared. Relative was also measured through real-time quantitative...
Broody behavior is regulated by hypothalamic prolactin secretion, which seriously affects egg production in poulty production. Numerous studies have provided evidence that animal governed dynamic bidirectional communication between specific gut bacteria and their host via the Brain-Gut-Microbiome Axis. However, little research focused on how microbiota influence broody poultry. In this study, Zhedong white geese laying brooding phases were selected. Ten differentially abundant cecum detected...
Rationale: Pancreatic cancer, comprising mostly pancreatic ductal adenocarcinoma (PDAC), is a highly malignant disease, typically known as hypoxic tumor microenvironment. The application of PDT in cancer clinic still hampered by several shortcomings, including the (i) deep location (ii) tissue damage induced optical fibers, (iii) microenvironment, (iv) short excitation wavelengths traditional photosensitizers, and (v) poor delivery efficiency photosensitizers. Methods: We designed an organic...
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with a 5 year survival rate less than 12%. This closely related to the unique tumor microenvironment (TME), which characterized by hypovascular and hyperdense extracellular matrix, making it difficult for drugs permeate center. Near-infrared fluorescence (NIRF) imaging, has high sensitivity resolution, may improve of PDAC patients. In this study, we first used JS-K (O2-(2,4-dinitrophenyl) 1-[(4-ethoxycarbonyl)...
Synaptojanin 2 Binding Protein (SYNJ2BP) is essential to cell proliferation. Previous studies show that SYNJ2BP participates in sprouting angiogenesis, which plays an important part several abnormal conditions including cancer. However, the activity of hepatocellular carcinoma (HCC) has not been elucidated yet. Firstly, real-time PCR and western blotting (WB) were adopted evaluate expressions HCC tissues lines. Secondly, we did follow-up prognostic study explore association expression...
Changes in microRNAs (miRs) contribute to the alternative chemo-resistance of cancers. Bortezomib (BTZ) is a well-characterized anticancer agent that inhibits proteasome, and its effect associated with function miRs. Based on data microarray assay comprehensive bioinformatics analyses, current study, we explored role miR-466 downstream effector CCND1 BTZ-resistance non-small-cell lung cancer (NSCLC) cells.miR expression profiles NSCLC tissues paratumor were determined assay. The potential...
RNA interference (RNAi) technology has been widely used to knockdown target genes via post-transcriptional silencing. In plants, RNAi is as an effective tool with diverse applications being developed such resistance against insects, fungi, viruses, and metabolism manipulation. To develop genetically modified (GM) traits for insect control, a transgene created composed of inversely-repeated sequence the gene spacer region inserted between repeats. The design subject form self-complementary...
Extracellular vesicle (EV) microRNAs have been documented in several studies to significantly different expressions hepatitis B virus (HBV)-related liver diseases, such as hepatocellular carcinoma (HCC). The current work aimed observe the characteristics of EVs and EV miRNA patients with severe injury chronic (CHB) HBV-associated decompensated cirrhosis (DeCi).The characterization serum was carried out for three groups, namely, injury-CHB, DeCi, healthy controls. miRNAs were analyzed using...
e15013 Background: Next-generation sequencing (NGS) can produce up to 6 Tb of data per run with single-nucleotide accuracy, making it ideal for quantifying isomiRs, which encompass both canonical miRNAs and their variants, clinical applications. However, NGS has poor reproducibility low sample throughput in circulating isomiRs due significant technical variations the limitations multiplex strategy, as evidenced by fact that no isomiR technique been successfully used diagnose cancer. Methods:...
Axion-like particles (ALPs) and dark photons (DPs) are viable matter particle candidates. We have searched for possible ALP/DP signals in the PandaX-4T liquid xenon detector using 94.8 days of data. A binned likelihood fit is constructed to search mono-energetic peaks induced by absorption processes between ALPs/DPs atomic electrons xenon. detailed temporal model decays associated with isotopes introduced constrain number background events. No signal excess over expectations observed, we...
Abstract Objective: Hepatocellular carcinoma(HCC),the most prevalent form of liver cancer, owns high morbidity and mortality. Early diagnosis for HCC is critical the treatment prognosis. plays an important role in improvement Methods: All clinical characteristics 233 participants from multicenter were collected, including 115 patients, 103 patients with cirrhosis, 15 samples healthy individuals. We identified several indicators significantly associated through logistic analysis to develop...