A5100615869- Per- and polyfluoroalkyl substances research
- Toxic Organic Pollutants Impact
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Air Quality and Health Impacts
- Circular RNAs in diseases
- Environmental Toxicology and Ecotoxicology
- Effects and risks of endocrine disrupting chemicals
- Prostate Cancer Treatment and Research
- RNA modifications and cancer
- Gastric Cancer Management and Outcomes
- Mercury impact and mitigation studies
- Heavy Metal Exposure and Toxicity
- Lung Cancer Treatments and Mutations
- Nitric Oxide and Endothelin Effects
- Cancer Genomics and Diagnostics
- Radiopharmaceutical Chemistry and Applications
- Vitamin D Research Studies
- Birth, Development, and Health
- Atmospheric chemistry and aerosols
- Cancer, Lipids, and Metabolism
- Colorectal Cancer Treatments and Studies
- Ovarian cancer diagnosis and treatment
- Esophageal Cancer Research and Treatment
- Selenium in Biological Systems
Nanjing Medical University
2013-2025
Sichuan University
2024-2025
Yili Normal University
2025
Second Affiliated Hospital of Dalian Medical University
2022-2025
Dalian Medical University
2025
West China Hospital of Sichuan University
2025
Lanzhou University
2025
Lanzhou University Second Hospital
2025
Dalian University of Technology
2015-2024
Union Hospital
2024
Purpose There is currently no standard treatment strategy for patients with advanced metastatic gastric cancer experiencing progression after two or more lines of chemotherapy. We assessed the efficacy and safety apatinib, a novel vascular endothelial growth factor receptor 2 tyrosine kinase inhibitor, in gastroesophageal junction adenocarcinoma whom at least prior chemotherapy had failed. Patients Methods This was randomized, double-blind, placebo-controlled phase III trial. from 32 centers...
Abstract Sirtuin 3 (SIRT3) is well known as a conserved nicotinamide adenine dinucleotide + (NAD )-dependent deacetylase located in the mitochondria that may regulate oxidative stress, catabolism and ATP production. Accumulating evidence has recently revealed SIRT3 plays its critical roles cardiac fibrosis, myocardial fibrosis even heart failure (HF), through deacetylation modifications. Accordingly, discovery of activators elucidating their underlying mechanisms HF should be urgently...
The objective of this study was to elucidate the mechanisms by which nitric oxide (NO) inhibits rat aortic smooth muscle cell (RASMC) proliferation. Two products arginine-NO pathway interfere with growth distinct mechanisms. N(G)-hydroxyarginine and NO appear proliferation inhibiting arginase ornithine decarboxylase (ODC), respectively. S-nitroso-N-acetylpenicillamine, (Z)-1-[N-(2-aminoethyl)-N-(2-aminoethyl)-amino]-diazen-1-ium-1,2-diolate, a nitroaspirin derivative (NCX 4016), each is...
Abstract The potential toxicity of perfluorooctane sulfonate (PFOS), an environmentally persistent organic pollutant, is great concern. present study examines the ability PFOS to disturb thyroid function and possible mechanisms involved in PFOS‐induced hormone alteration. Male Sprague‐Dawley rats were exposed 1.7, 5.0, 15.0 mg/L drinking water for 91 consecutive days. Serum was collected analysis total free thyroxine (T 4 ), triiodothyronine 3 thyrotrophin (TSH). Thyroid liver removed...
Perfluorinated compounds (PFCs) are ubiquitous pollutants. Experimental data suggest that they may be associated with adverse health outcomes, including asthma. However, there is little supporting epidemiological evidence.A total of 231 asthmatic children and 225 nonasthmatic controls, all from northern Taiwan, were recruited in the Genetic Biomarkers study for Childhood Asthma. Structure questionnaires administered by face-to-face interview. Serum concentrations 11 PFCs levels immunological...
Epidermal growth factor receptor (EGFR) mutations are the strongest response predictors to EGFR tyrosine kinase inhibitors (TKI) therapy, but knowledge of mutation frequency on lung adenocarcinoma is still limited retrospective studies. The PIONEER study (NCT01185314) a prospective molecular epidemiology in Asian patients with newly diagnosed advanced adenocarcinoma, aiming prospectively analyze status IIIB/IV treatment-naïve adenocarcinomas Asia. We report mainland China subset results....
A fluorochemical industrial park was built in 2004 Fuxin, China, for the production of polytetrafluoroethylene (PTFE) and perfluorobutane sulfonate (PFBS). Yet little is known about distribution fluorochemicals environment people living around park. In this study, environmental samples were collected from 22 sites Fuxin to investigate extent perfluorinated compound (PFC) contamination park, drinking water public supply system groundwater shallow aquifers private wells near Serum also...
Neuropathic pain resulting from nerve lesions or dysfunction represents one of the most challenging neurological diseases to treat. A better understanding molecular mechanisms responsible for causing these maladaptive responses can help develop novel therapeutic strategies and biomarkers neuropathic pain. We performed a miRNA expression profiling study dorsal root ganglion (DRG) tissue rats four weeks post spinal ligation (SNL), model TaqMan low density arrays identified 63 miRNAs whose...
Emerging evidence has suggested that long noncoding RNAs (lncRNA) involved in the development and progression of cancer. Triple negative breast cancer (TNBC) was an aggressive type with high rates recurrence metastasis. The pathogenesis TNBC is largely unknown. Recent studies lncRNA HCP5 plays important role carcinogenesis. purpose this study to examine function mechanism TNBC. We observed upregulated cell lines specimens. knockdown induced apoptosis, inhibited proliferation orthotopic...
Spinal cord injury (SCI) is a catastrophic disease which has complicated pathogenesis including inflammation, oxidative stress and glial scar formation. Astrocytes are the most abundant cells in central nervous system fulfill homeostatic functions. Recent studies have described new reactive phenotype of astrocytes, A1, induced by may negative effects SCI. As Notch signaling pathway been linked to cell differentiation we aimed investigate its potential role astrocytes Contusive SCI rat model...
Ovarian cancer is the third most common in female reproductive organs and epithelial ovarian has highest lethality of all gynecological cancers. Pomegranate fruit juice (PFJ) been shown to inhibit growth several types other than cancer. In this study, we exposed cell line A2780 PFJ two its components (ellagic acid luteolin). MTT wound healing assays demonstrated that three treatments suppressed proliferation migration cells. addition, western blotting ELISA showed expression levels MMP2 MMP9...
Two distinct antagonist-bound structures of CysLT 1 R reveal unique ligand-binding modes and signaling mechanisms.
Long noncoding RNA HOTTIP is a crucial regulator in multiple types of cancer, including ovarian cancer (OC). However, the biological roles and underlying mechanisms OC have rarely been studied. Hence, this study aimed to investigate functional correlation between pyroptosis progression. The expression tissues cell lines was characterized by quantitative real-time PCR. Cell proliferation evaluated using Counting Kit-8 clone formation assays. Western blot performed quantify protein levels. A...
The objectives of this study were to determine whether rat aortic smooth muscle cells (RASMC) express arginase and elucidate the possible mechanisms involved in regulation expression. results show that RASMC contain basal I (AI) activity, which is significantly enhanced by stimulating with either interleukin (IL)-4 or IL-13, but II (AII) expression was not detected under any condition studied here. We further investigated signal transduction pathways responsible for AI induction. mRNA...
Doxorubicin (ADR) is successfully used to treat breast cancer, however, it often associated with the acquired resistance of cancer cells which eliminates therapeutic efficiency ADR, leading relapse and a poorer prognosis. It has been reported that microRNA-200c (miRNA-200c), non-coding RNA, important in epithelial mesenchymal transition (EMT) metastasis cells. Recent evidence demonstrated miRNA-200c also regulated chemotherapeutic drug resistance, precise mechanism by this occurs remains...