A5100630786- Occupational and environmental lung diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- MicroRNA in disease regulation
- Cardiac Fibrosis and Remodeling
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Bone Metabolism and Diseases
- Liver physiology and pathology
- Medicinal Plant Pharmacodynamics Research
- Lung Cancer Treatments and Mutations
- Inflammasome and immune disorders
- Cancer Genomics and Diagnostics
- Adipokines, Inflammation, and Metabolic Diseases
- Biomarkers in Disease Mechanisms
- TGF-β signaling in diseases
- Neurogenesis and neuroplasticity mechanisms
- Cancer Mechanisms and Therapy
- Bone health and treatments
- Nerve injury and regeneration
- Signaling Pathways in Disease
- Adenosine and Purinergic Signaling
- Ideological and Political Education
- Bone and Dental Protein Studies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Renin-Angiotensin System Studies
Xuzhou Medical College
2025
Harbin Medical University
2012-2024
North China University of Science and Technology
2011-2024
Fourth Affiliated Hospital of Harbin Medical University
2024
Burning Rock Biotech (China)
2022
Air Force Medical University
2022
Nanjing Agricultural University
2020
Yantaishan Hospital
2020
Chinese Academy of Medical Sciences & Peking Union Medical College
2017
Tianjin Medical University General Hospital
2017
Summary Aims To study the role of curcumin on glioma cells via SHH / GLI 1 pathway in vitro and vivo . Methods The effects proliferation, migration, apoptosis, signaling, target genes expression were evaluated multiple cell lines A U87‐implanted nude mice model was used to tumor volume suppression efficacy 1. Results Curcumin showed cytotoxic Both mRNA protein levels signaling ( S hh, mo, 1) downregulated a dose‐ time‐dependent manner. Several 1‐dependent C yclin D 1, B cl‐2, F oxm1) also...
Doxorubicin (ADR) is successfully used to treat breast cancer, however, it often associated with the acquired resistance of cancer cells which eliminates therapeutic efficiency ADR, leading relapse and a poorer prognosis. It has been reported that microRNA-200c (miRNA-200c), non-coding RNA, important in epithelial mesenchymal transition (EMT) metastasis cells. Recent evidence demonstrated miRNA-200c also regulated chemotherapeutic drug resistance, precise mechanism by this occurs remains...
// Jinquan Cai 1, 7, * , Ping Zhu 4, Chuanbao Zhang 2, 3, Qingbin Li 7 Zhiliang Wang Guanzhang Guangzhi Pei Yang Jianlong Bo Han Chuanlu Jiang Ying Sun Tao 5, 6, 1 Department of Neurosurgery, The Second Affiliated Hospital Harbin Medical University, Harbin, China 2 Beijing Neurosurgical Institute, Capital Beijing, 3 Tiantan Hospital, 4 Otolaryngology, Union Tongji College, Huazhong University Science and Technology, Wuhan, 5 Institute for Brain Disorders Tumor Center, 6 National Clinical...
Background Myofibroblast differentiation, characterized by α-smooth muscle actin (α-SMA) expression, is a key process in organ fibrosis, and induced TGF-β. Here we examined whether an anti-fibrotic agent, N-acetyl-seryl-aspartyl-lysylproline (Ac-SDKP), can regulate induction of TGF-β signaling myofibroblast differentiation as potential component its mechanism vivo vitro. Methodology/Principal Findings Rat pulmonary fibroblasts were cultured vitro divided to 4 groups 1) control; 2) TGF-β1; 3)...
The TP53 tumor suppressor gene plays an important role in preventing and inhibiting the growth of by regulating cell cycle, apoptosis DNA repair. Meanwhile, is one most frequently altered non-small lung cancer (NSCLC) patients. Mutant (TP53-MUT) may lose activity gain promoting functions, which play risk, therapy resistance poor prognosis. impact TP53-MUT on prognosis NSCLC patients need to be further studied.We obtained genomic clinical data from Cancer Genome Atlas (TCGA). Mutation...
Quercetin exerts anti-inflammatory, anti-oxidant and other protective effects. Previous studies have shown that senescent cells, such as fibroblasts type II airway epithelial are strongly implicated in the development of pulmonary fibrosis pathology. However, role macrophages during silicosis remains unclear. We investigated effects quercetin on macrophage senescence fibrosis, explored underlying mechanisms. Mice were randomized to six model groups. Vitro was also established by culturing...
The activation of angiotensin II type 2 receptor (AT R) has been considered cardioprotective. However, there are controversial findings regarding the role overexpressing AT R in heart. Using transgenic mice with different levels gene overexpression heart (1, 4, or 9 copies transgene: Tg 1 , 4 ), we studied effect on left ventricular remodeling and dysfunction post–myocardial infarction (MI). their wild-type littermates were divided into (1) sham MI, (2) MI plus vehicle, (3) antagonist....
Glycolytic reprogramming is an important metabolic feature in the development of pulmonary fibrosis. However, specific mechanism glycolysis silicosis still not clear. In this study, silicotic models and silica-induced macrophage were used to elucidate induced by silica. Expression levels key enzymes activation indicators analyzed Western blot, qRT-PCR, IHC, IF analyses, using a lactate assay kit. We found that silica promotes expression HK2, PKM2, LDHA, factors iNOS, TNF-α, Arg-1, IL-10,...
Abstract Promoting regenerative repair, including neurogenesis and angiogenesis, may provide a new therapeutic strategy for treatment of stroke. P53, well-documented transcription factor, has been reported to be involved in cerebral ischemia also serves as an important regulator vascular endothelial growth factor (VEGF). However, the role p53 endogenous repair after brain is poorly understood. In this study, we investigated effects PFT-α, specific inhibitor on angiogenesis improvement...
Silica-induced inflammatory activation is associated with silicosis and various non-respiratory conditions. The present study was designed to examine the anti-inflammatory effects of N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP) on lung macrophages bone osteoclasts after silica inhalation in rats.Wistar rats NR8383 RAW 264.7 cell lines were used study. receptor activator nuclear factor kappa-B ligand (RANKL) toll-like 4 (TLR4) signaling pathways measured tissue or NR8383/RAW cells exposed...
Complications due to brain edema and breakdown of blood barrier are an important factor affecting the treatment effects patients with severe carotid stenosis. In this study, we investigated protective ischemic postconditioning on disruption via establishing rat model hypoperfusion stenosis.Wistar stenosis was established by binding a stainless microtube both arteries. Ischemic procedure consisted three cycles 30 seconds ischemia reperfusion. Brain evaluated measuring cerebral water content,...
Cellular senescence has been considered an important driver of many chronic lung diseases. However, the specific mechanism cellular in silicosis is still unknown. In present study, silicotic rats and osteoclast stimulatory transmembrane protein ( Ocstamp ) overexpression MLE‐12 cells were used to explore OC‐STAMP alveolar epithelial cell type II (AEC2). We found increasing level AEC2 rats. Overexpression promoted epithelial‐mesenchymal transition (EMT), endoplasmic reticulum (ER) stress,...
The mechanisms involved in the malignant progression of lung adenocarcinoma (LUAD) are still inconclusive. Fibrinogen-like protein 1 (FGL1) and LAG3 a pair immune checkpoints that create an inhibitory microenvironment tumors. However, other roles FGL1 LUAD have not been extensively studied. Our study aims to explore role provide new therapeutic targets strategies for treatment.Differential gene expression was analyzed using Gene Expression Profiling Interactive Analysis (GEPIA), Oncomine,...
To examine a novel strategy to enhance the survival of grafted neural stem cells (NSCs) in stroke model.Using cell counting kit-8 (CCK-8) and TUNEL assay test protective effects p53 inhibitor, pifithrin-α (PFT-α), on oxygen glucose deprivation (OGD) NSCs. We compared vehicle + NSCs FFT-α efficacy transplantation rat model using behavioral analysis, immunohistochemistry, etc.Pifithrin-α increased viability decreased apoptosis after OGD vitro. By vivo studies, we showed that best recovery...
Gliomas are malignant primary brain tumors with poor prognosis. Recently, research was indicative of a tight connection between tumor malignancy and genetic alterations. Here, we propose an oncogenic implication transforming acidic coiled-coil-containing protein 3 (TACC3) in gliomas. By comprehensively analyzing the Chinese glioma genome atlas (CGGA) publicly available data, demonstrated that TACC3 were overexpressed along grade served as independent negative prognostic biomarker for...
Currently, the role of interleukin-10 (IL-10) as an anti-inflammatory factor in occurrence and development heart disease is still unclear. This study aimed to observe dynamic changes expression IL-10 serum myocardial tissues investigate relationship with macrophage activation cardiomyocyte apoptosis during infarction (MI).Mice models MI were prepared by ligating anterior descending branch coronary artery. The animals classified into sham operation group (the control group), day 1, 7, 14, 28...
Abstract Background The aim was to explore the effect of macrophage polarization and macrophage‐to‐myofibroblast transition (MMT) in silicosis. Methods Male Wistar rats were divided into a control group silicosis developed using HOPE MED 8050 dynamic automatic dusting system. Murine MH‐S cells randomly an SiO 2 group. pathological changes lung tissue observed hematoxylin eosin (HE) Van Gieson (VG) staining. distribution location marker (F4/80), M1 (iNOS), M2 (CD206), myofibroblast (α‐smooth...