A5000077691- Venous Thromboembolism Diagnosis and Management
- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Anesthesia and Pain Management
- Anesthesia and Sedative Agents
- Airway Management and Intubation Techniques
- Nausea and vomiting management
- Radiomics and Machine Learning in Medical Imaging
- Cancer Immunotherapy and Biomarkers
- Anesthesia and Neurotoxicity Research
- Intensive Care Unit Cognitive Disorders
- Esophageal Cancer Research and Treatment
- Cardiac tumors and thrombi
- Acute Kidney Injury Research
- Hemodynamic Monitoring and Therapy
- Gastric Cancer Management and Outcomes
- Tracheal and airway disorders
- Cardiac Arrest and Resuscitation
- Ferroptosis and cancer prognosis
- Central Venous Catheters and Hemodialysis
- Ultrasound in Clinical Applications
- Medical Imaging Techniques and Applications
- Respiratory Support and Mechanisms
- Immune Cell Function and Interaction
Capital Medical University
2016-2025
Beijing Chao-Yang Hospital
2011-2025
Wuhan No.1 Hospital
2025
The People's Hospital of Guangxi Zhuang Autonomous Region
2024
Capital University
2011-2023
Beijing Friendship Hospital
2020-2023
Liaoning Cancer Hospital & Institute
2020-2023
China Medical University
2020-2023
Zhejiang University
2020-2022
Fujian Provincial Hospital
2021
Platelet—collagen interactions play a fundamental role in the process of arterial thrombosis. The major platelet collagen receptor is glycoprotein VI (GPVI). Here, we determined effects soluble dimeric form GPVI on adhesion vitro and vivo. We fused extracellular domain with human immunoglobulin Fc domain. (GPVI-Fc) specifically bound to immobilized collagen. Binding GPVI-Fc was inhibited competitively by GPVI-Fc, but not control lacking external CHO cells that stably express platelets...
To observe the protective effects of dexmedetomidine (Dex) postconditioning on myocardial ischemia/reperfusion injury (IRI) and to explore its potential molecular mechanisms.One-hundred forty-seven male Sprague-Dawley rats were randomly divided into five groups receiving different treatments: Sham, (I/R), Dex, Brusatol, Dex + Brusatol. By in vivo rat model IRI, cardioprotective evaluated by assessing serum CK-MB cTnI levels, HE Tunel staining infarct size. Furthermore, oxidative...
Lung cancer screening using computed tomography (CT) has increased the detection rate of small pulmonary nodules and early-stage lung adenocarcinoma. It would be clinically meaningful to accurate assessment nodule histology by CT scans with advanced deep learning algorithms. However, recent studies mainly focus on predicting benign malignant nodules, lacking model for risk stratification invasive We propose an ensemble multi-view 3D convolutional neural network (EMV-3D-CNN) study include...
BackgroundIn recent years, a growing number of patients with multiple primary lung cancer (MPLC) are being diagnosed, and subset these is found to have large lesions at the time diagnosis, which referred as 'super MPLC'.MethodsHere, we perform whole exome sequencing (WES) immunohistochemistry (IHC) analysis PD-L1 CD8 on 212 tumor samples from 42 super MPLC.FindingsWe report genomic alteration landscape MPLC. EGFR, RBM10 TP53 mutation TERT amplification important molecular events in evolution...
ABSTRACT Background Ipsilateral shoulder pain (ISP) is a common complication following video‐assisted thoracoscopic surgery (VATS), significantly affecting postoperative recovery and quality of life. This study aimed to evaluate the relationship between intraoperative upper limb positioning, occurrence ISP, with goal optimizing positioning reduce complications. Methods prospective cohort included 252 patients undergoing VATS for lung resection. The A angle (shoulder flexion) B abduction)...
Inflammatory biomarkers have shown prognostic value in Non-Small Cell Lung Cancer (NSCLC), but the inclusion of Adenocarcinoma In Situ (AIS) cases previous studies may introduce bias. This study aims to evaluate significance inflammatory NSCLC while excluding AIS. included patients who received surgery for lung carcinoma from August 2016 and 2019. We collected demographic, clinical, laboratory, outcome information. were analyzed using receiver operating characteristic (ROC) curves,...
Venous thromboembolism (VTE) is a common postoperative complication. Previous studies have shown that the incidence of VTE after major thoracic surgery ranges from 2.3% to 15%. However, there been no such data China so far. To evaluate VTE, we conducted single-centre, prospective cohort study.Patients who underwent lung resections between July 2016 and March 2017 were enrolled in this study. None patients received any prophylaxis perioperatively. All screened for deep venous thrombosis (DVT)...
Cisplatin-based chemotherapy is the standard therapy used to treat non-small-cell lung cancer. However, its efficacy largely limited due development of drug resistance. The exact mechanism in which cancer cells develop resistance not yet fully understood. purpose present study test role volume-sensitive Cl − channels cisplatin human adenocarcinoma (A549 cells) using patch-clamp recording, cell volume measurement and apoptosis assay. results showed that treatment induced an apoptotic decrease...
The purpose of this study was to investigate the incidence venous thromboembolism (VTE) in epidermal growth factor receptor (EGFR) mutations patients with lung adenocarcinoma, provide clinical basis for perioperative prevention and treatment VTE cancer.This included invasive adenocarcinoma confirmed by pathology from July 2016 March 2018 after surgical pulmonectomy Thoracic Surgery Department Beijing Chaoyang Hospital. All enrolled were tested relevant gene mutations. classified as subtypes...
Abstract Introduction Lung adenocarcinoma (LUAD) is a common pathological type of lung cancer. The presence lymph node metastasis plays crucial role in determining the overall treatment approach and long‐term prognosis for early LUAD, therefore accurate prediction essential to guide decisions ultimately improve patient outcomes. Methods We performed transcriptome sequencing on T1 LUAD patients with positive or negative metastases combined this data Cancer Genome Atlas Program cohort identify...
Venous thromboembolism (VTE) is an insidious disease with significant morbidity and mortality. We conducted a retrospective single-center study on patients who underwent thoracic surgery developed novel VTE risk assessment model (RAM).Patients between July 2016 December 2017 (n=533) at the Beijing Chao-Yang Hospital were enrolled in this study. None of received any prophylaxis perioperatively. Lower limbs Doppler ultrasonography was performed before after for deep venous thrombosis (DVT)...
Fascia iliaca compartment block (FICB) is an anterior approach to the lumbar plexus and provides effective adjunctive analgesia for total hip arthroplasty (THA).As a case series study, 28 patients (≥ 65 years old) with THA were received modified in-plane ultrasound-guided supra-inguinal (S-FICB) as analgesic adjunct evaluate effectiveness local anesthetic diffusion magnetic resonance imaging (MRI). A combination of propofol sufentanil was administered conduct target-controlled infusion.The...
Background: Lung adenocarcinoma (LUAD) is the most common variant of non–small cell lung cancer (NSCLC) across world. Recently, rapid development immunotherapy has brought a new dawn for LUAD patients. Closely related to tumor immune microenvironment and functions, more checkpoints have been discovered, various treatment studies targeting these novel are currently in full swing. However, on phenotype clinical significance still limited, only minority patients with can benefit from...
Background. Eosinophilic angiocentric fibrosis (EAF) is a rare benign condition of unknown aetiology that causes stenosis the upper respiratory tract. It most commonly found at nasal septum and sinus mucosa causing mucosal thickening obstructive symptoms. The diagnosis mainly based on characteristic histologic findings. Case Report. A 27-year-old young woman presented with slow growing mass her anterior for over eight years. She complained persistent obstruction, epistaxis, sometimes...
Abstract Background To evaluate the correlation and accuracy of dual‐energy CT (DECT) (70/Sn150) low‐dose volume perfusion (VPCT) parameters for diagnosis solitary pulmonary nodules (SPN). Methods A total 15 patients with benign SPN (mean age 56 ± 7 years) 34 malignant clinical indication surgery 58 6 were enrolled from July 2017 to September 2019 at a single institution. All underwent VPCT scan 114 mm on z‐axis venous phase enhancement DECT (70/150 Sn) just before same day. findings studied...
Many upper respiratory pathogens cause similar symptoms. In China, routine molecular tests for are not widely performed and antibiotics abuse in treating tract infections (URTIs) is a major public health concern.We qualitative real-time PCR to detect common including 9 viruses 3 bacteria 1221 nasopharyngeal swabs from patients with fever influenza-like symptoms Chinese city. A quantitative was also measure the bacterial density of colonizing Streptococcus pneumoniae these samples.We found...
Venous thromboembolism (VTE) is a common postoperative complication of lung cancer, but the incidence and risk stratification VTE in stage IA non-small-cell cancer (NSCLC) patients remains unclear, therefore we conducted single-center prospective study.A total 314 consecutive hospitalized for surgery diagnosed with NSCLC from January 2017 to July 2021 were included. The divided into group non-VTE according whether occurred after operation. patient's age, operation time, D-dimer (D-D) value,...