A5026467157- Pancreatic and Hepatic Oncology Research
- Inflammatory Biomarkers in Disease Prognosis
- Venous Thromboembolism Diagnosis and Management
- Radiomics and Machine Learning in Medical Imaging
- Vascular Procedures and Complications
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Central Venous Catheters and Hemodialysis
- Cancer, Lipids, and Metabolism
- Pediatric Hepatobiliary Diseases and Treatments
- Immune Cell Function and Interaction
- Liver Disease Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Gastric Cancer Management and Outcomes
- Cancer Immunotherapy and Biomarkers
- Ferroptosis and cancer prognosis
- Immune cells in cancer
- Intraperitoneal and Appendiceal Malignancies
- Hepatitis C virus research
- Parathyroid Disorders and Treatments
- Gastrointestinal Tumor Research and Treatment
- HER2/EGFR in Cancer Research
- Cytomegalovirus and herpesvirus research
- Cancer-related cognitive impairment studies
- Pancreatitis Pathology and Treatment
- MRI in cancer diagnosis
Capital Medical University
2021-2025
Beijing Chaoyang Emergency Medical Center
2021-2025
Beijing Chao-Yang Hospital
2023-2024
Capital University
2022-2023
Background Sarcopenia has the potential to impact postoperative results and extended prognosis of various types tumors. Nevertheless, specific sarcopenia on long-term survival pancreatic cancer (PC) following pancreaticoduodenectomy (PD) remains inadequately elucidated. This study investigates significance according Asian standards complications in PC patients who have undergone PD. Methods retrospective systematically analyzed with underwent PD from January 2015 December 2022. was diagnosed...
Duodenal adenocarcinoma (DA) has a high recurrence rate, making the prediction of after surgery critically important. Our objective is to develop machine learning-based model predict postoperative DA. We conducted multicenter, retrospective cohort study in China. 1830 patients with DA who underwent radical between 2012 and 2023 were included. Wrapper methods used select optimal predictors by ten learning learners. Subsequently, these learners utilized for development. The model's performance...
Objective: The study aimed to develop a physiologically based pharmacokinetic (PBPK) model predict steady state trough concentrations (Cmin) and CDK4/6 occupancy in plasma cerebrospinal fluid (CSF) for abemaciclib (ABE) its three active metabolites. Additionally, biomarker was constructed simulate changes pRB TOPO-IIα expression. Methods: population PBPK models of ABE were developed using physicochemical, pharmacokinetics (PK), occupancy, biomarker, physiological properties. These then...
Background To investigate the clinical significance of preoperative inflammatory status in patients with pancreatic head carcinoma (PHC), we performed a single-center study to assess it. Method We studied total 164 PHC undergoing PD surgery (with or without allogeneic venous replacement) from January 2018 April 2022. Systemic immune-inflammation index (SII) was most important peripheral immune predicting prognosis according XGBoost analysis. The optimal cutoff value SII for OS calculated...
The incidence of duodenal adenocarcinoma is increasing, with limited studies on this disease published. This multicenter retrospective study aimed to analyze the clinicopathologic features and identify prognostic factors for postoperative survival.
To investigate venous thromboembolism (VTE) in patients undergoing distal cholangiocarcinoma (dCCA) surgery, we performed a single-center study to assess its prevalence, risk factors, prognosis.We studied total of 177 dCCA surgery from January 2017 April 2022. Demographic, clinical data, laboratory data (including lower extremity ultrasound findings), and outcome variables were obtained, compared between VTE non-VTE groups.Of the (aged 65.2 ± 9.6 years; 108 (61.0%) male), 64 developed after...
Background The preoperative prognostic nutritional index (PNI) is an indicator of systemic immune-nutritional condition and a well-known biomarker in cancer patients. This study aims to reflect the correlation between PNI prognosis patients with borderline resectable pancreatic (BRPC) after pancreaticoduodenectomy (PD). Methods Medical records BRPC PD Jan 2011 Dec 2021 our hospital were retrospectively analyzed. was calculated, receiver operating characteristic curve obtained based on 1-year...
As a common malignant tumour, pancreatic cancer (PC) has the worst clinical outcome. Early evaluation of postoperative prognosis certain value. Low-density lipoprotein cholesterol (LDL-c), which is mainly composed cholesteryl esters, phospholipids, and proteins, plays an important role in transporting into peripheral tissues. LDL-c also been reported to be correlated with occurrence progression tumours can predict various tumours.To determine correlation between serum level outcome PC...
Observational studies have demonstrated an association between primary sclerosing cholangitis (PSC) and thyroid dysfunction (TD). However, the causal relationship PSC TD remains uncertain. The purpose of this study is to investigate associations specific direction these two conditions. Gaining insight into potential valuable for elucidating pathogenesis devising innovative approaches prevention treatment its associated complications.We conducted a bidirectional two-sample Mendelian...
Correctly distinguishing mass-forming chronic pancreatitis (MFCP) from pancreatic cancer (PC) is of clinical significance to determine optimal therapy and improve the prognosis patients. According research, inflammation status in PC different that MFCP. Mean platelet volume/platelet ratio (MPR) a platelet-related index which has been proven be valuable diagnosis various malignant cancers due change mean volume count under abnormal inflammatory conditions caused by tumors. Thus, we conducted...
BACKGROUND The relationship between preoperative inflammation status and tumorigenesis as well tumor progression is widely acknowledged. AIM To assess the prognostic significance of inflammatory biomarkers in patients with distal cholangiocarcinoma (dCCA) who underwent pancreatoduodenectomy (PD). METHODS This single-center study included 216 dCCA after PD January 1, 2011, December 31, 2022. individuals were categorized into two sets based on their systemic response index (SIRI) levels: A low...
Observational studies have shown that there is a connection between blood biomarkers and the occurrence of acute pancreatitis (AP). Nevertheless, causal relationships are still not clear. The purpose this study was to evaluate association AP.
Hepatocellular carcinoma (HCC) and biliary tract cancer (BTC) are significant health challenges in China because of their high prevalence mortality rates. Advances molecular diagnostics have opened new avenues for personalized treatment strategies. This consensus provides a comprehensive update on the clinical applications HCC BTC addresses urgent need strategies tailored to Chinese population, emphasizing importance markers guiding targeted therapies immunotherapies. By employing Delphi...
Pancreatic ductal adenocarcinoma (PDAC) is a malignancy characterized by challenging early diagnosis and poor prognosis. It believed that coagulation has an impact on the tumor microenvironment of PDAC. The aim this study to further distinguish coagulation-related genes investigate immune infiltration in PDAC.We gathered two subtypes from KEGG database, acquired transcriptome sequencing data clinical information PDAC Cancer Genome Atlas (TCGA) database. Using unsupervised clustering method,...
Background Portal vein thrombosis (PVT) is a common postoperative complication in patients with pancreatic cancer (PC), significantly affecting their quality of life and long-term prognosis. Our aim to establish new nomogram predict the risk PVT after PC surgery. Method We collected data from 416 who underwent surgery at our hospital between January 2011 June 2022. This includes 87 329 without PVT. The were randomly divided into training group validation ratio 7:3. constructed model using...
Abstract Background: To investigate venous thromboembolism (VTE) in patients undergoing distal cholangiocarcinoma (dCCA) surgery, we performed a single-center study to assess its prevalence, risk factors, prognosis. Method : We studied total of 177 dCCA surgery from January 2017 April 2022. Demographic, clinical data, laboratory data (including lower extremity ultrasound findings), and outcome variables were obtained, compared between VTE non-VTE groups. Results: Of the (aged 65.2±9.6years;...
Abstract Background: Venous thromboembolism (VTE) is a common postoperative complication in patients with borderline resectable pancreatic cancer (BRPC), which seriously affects the quality of life and prognosis. We aimed to establish new nomogram predict VTE risk after BRPC surgery. Method : A total 301 consecutive adult who underwent surgery between Jan. 2011 Dec. 2021 our institution were retrospectively reviewed. Included cohort 67 developed 79 non-VTE patients. The randomly divided into...
Abstract Background: To investigate the clinical significance of preoperative inflammatory status in patients with pancreatic head carcinoma (PHC), we performed a single-center study to assess it. Method : We studied total 164 PHC undergoing PD surgery (with or without allogeneic venous replacement) from January 2018 April 2022. Systemic immune-inflammation index (SII) was most important peripheral immune predicting prognosis according XGBoost analysis. The optimal cutoff value SII for OS...
Abstract Background: Pancreatic ductal adenocarcinoma (PDAC) is the malignancy with difficult early diagnosis and poor prognosis. The coagulation believed to affect tumor microenvironment of PDAC. purpose this study further identify coagulation-related genes explore immune infiltration in Methods: Two subtypes were collected KEGG database. We obtained transcriptome sequencing data clinical information PDAC from Cancer Genome Atlas (TCGA) Patients divided into different clusters using...
Background: Distal Cholangiocarcinoma (dCCA) is the epithelial cell malignancies that occurs at distal common bile duct. There a lack of studies exploring performance deep learning survival model in dCCA. We investigated whether novel models can make dCCA risk prediction over existing statistical and machine models.Methods: This retrospective study involved 169 consecutive patients with (training cohort, n=118; validation n=51), including outcomes, Albumin / fibrinogen ratio (AFR), treatment...