A5101945489- Signaling Pathways in Disease
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer, Hypoxia, and Metabolism
- MicroRNA in disease regulation
- vaccines and immunoinformatics approaches
- RNA Research and Splicing
- Ferroptosis and cancer prognosis
- Glycosylation and Glycoproteins Research
- Immunotherapy and Immune Responses
- Glioma Diagnosis and Treatment
- Monoclonal and Polyclonal Antibodies Research
- Cancer-related molecular mechanisms research
- Renal cell carcinoma treatment
- Radiomics and Machine Learning in Medical Imaging
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Cells and Metastasis
- Aluminum Alloys Composites Properties
- Cancer Immunotherapy and Biomarkers
- Single-cell and spatial transcriptomics
- Liver Disease Diagnosis and Treatment
- MRI in cancer diagnosis
- Circular RNAs in diseases
- Epigenetics and DNA Methylation
- Colorectal Cancer Treatments and Studies
- Advanced Neuroimaging Techniques and Applications
Second Affiliated Hospital of Harbin Medical University
2014-2024
Harbin Medical University
2013-2024
Dalian Medical University
2016-2024
Second Affiliated Hospital of Dalian Medical University
2017-2024
Weifang Medical University
2019-2023
Shanghai Jiao Tong University
2022-2023
Chengdu University of Traditional Chinese Medicine
2023
Fudan University Shanghai Cancer Center
2016-2020
Shanghai Center For Bioinformation Technology
2019-2020
Shanghai Ocean University
2019-2020
Summary Objective Micro RNA s (mi s) are noncoding small that control gene expression at the posttranscriptional level. Some dysregulated mi have been shown to play important roles in epileptogenesis. The aim of this study was determine if miR‐199a‐5p regulates seizures and seizure damage by targeting antiapoptotic protein silent information regulator 1 ( SIRT 1). Methods Hippocampal levels miR‐199a‐5p, 1, acetylated p53 were quantified quantitative real‐time polymerase chain reaction...
// Jinquan Cai 1, 7, * , Ping Zhu 4, Chuanbao Zhang 2, 3, Qingbin Li 7 Zhiliang Wang Guanzhang Guangzhi Pei Yang Jianlong Bo Han Chuanlu Jiang Ying Sun Tao 5, 6, 1 Department of Neurosurgery, The Second Affiliated Hospital Harbin Medical University, Harbin, China 2 Beijing Neurosurgical Institute, Capital Beijing, 3 Tiantan Hospital, 4 Otolaryngology, Union Tongji College, Huazhong University Science and Technology, Wuhan, 5 Institute for Brain Disorders Tumor Center, 6 National Clinical...
Abstract Neoantigens can function as actual antigens to facilitate tumor rejection, which play a crucial role in cancer immunology and immunotherapy. Emerging evidence revealed that neoantigens be used develop personalized, cancer-specific vaccines. To date, large numbers of immunogenomic peptides have been computationally predicted potential neoantigens. However, experimental validation remains the gold standard for clinical application. Experimentally validated are rare mostly appear...
Glioblastoma multiform (GBM) is the most common malignant primary brain tumor in adults. Radiotherapy plus concomitant and adjuvant TMZ chemotherapy current standard of care for patients with GBM. Matrix metalloproteinases (MMPs), a family zinc-dependent endopeptidases, are key modulators invasion metastasis due to their ECM degradation capacity. The aim present study was identify informative MMP member terms prognostic predictive ability GBM.The mRNA expression profiles all genes were...
Abstract Purpose: Glioma-initiating cells (GIC) are glioma stem–like that contribute to glioblastoma (GBM) development, recurrence, and resistance chemotherapy radiotherapy. They have recently become the focus of novel treatment strategies. Cyclophilin A (CypA) is a cytosolic protein belongs peptidyl–prolyl isomerase (PPIase) family major intracellular target immunosuppressive drug cyclosporin (CsA). In this study, we investigate functions CypA its mechanism action in GICs' development....
Malignant glioma is the most common type of human intracranial cancer and has poor prognosis due to its high recurrence invasiveness. However, molecular mechanisms underlying malignant phenotypes have still not been completely explored yet. miR-122 well documented act as a tumor suppressor for hepatocellular carcinoma breast cancer, but implication in progression clear In this study, we found that was underexpressed specimens cell lines, compared with normal brain tissues lines. The...
Gliomas are the most common primary intracranial malignant tumors in adults. Surgical resection followed by optional radiotherapy and chemotherapy is current standard therapy for glioma patients. Vimentin, a protein of intermediate filament family, could maintain cellular integrity participate several cell signal pathways to modulate motility invasion cancer cells. The purpose present research was identify relationship between vimentin expression clinical characteristics detect prognostic...
Recurrence and progression to higher grade lesions are key biological events characteristic behaviors in the evolution process of glioma.Malignant astrocytic tumors such as glioblastoma (GBM) most lethal intracranial tumors.However, clinical practicability significance molecular parameters for diagnostic prognostic prediction is still limited.In this study, we detected ATRX, IDH1-R132H Ki-67 by immunohistochemistry observed association with ATRX expression.There was a strong between loss...
Abstract: The aims of this study were to assess the effect transarterial chemoembolization (TACE) on circulating tumor cells (CTCs) in peripheral blood and right atrium patients with HCC evaluate whether perioperative shedding CTCs affects time progression HCC. Before after TACE, atrial samples (7.5 mL) collected from 42 enriched using EpCAM antibody-conjugated magnetic beads. number was 0–30 0–54 before respectively ( P =0.166), 0–65 0–98 =0.102). significantly different between two both...
Glioma is one of the most common and aggressive brain tumors in humans. The molecular cellular mechanisms responsible for onset progression glioma are elusive controversial. Centrosomal protein 55 (CEP55) was initially described as a highly coiled-coil that plays critical roles cell division, but recently identified being overexpressed many human cancers. function CEP55 has not previously been characterized glioma. We aim to discover effect mechanism development.qRT-PCR immunohistochemistry...
Tetrandrine (TET), a bisbenzylisoquinoline alkaloid isolated from the root of Hang-Fang-Chi (Stephania tetrandra S. Moore), exhibits broad pharmacological effects, including antitumor activity in various malignant neoplasms. Recently, beneficial effects TET on cytotoxicity towards tumor cells, radiosensitization, circumventing multidrug resistance, normal tissue radioprotection, and antiangiogenesis have been examined extensively. However, potential molecular mechanisms effect glioma are yet...
BACKGROUNDEndometriosis is a common gynaecological disease, but the pathogenesis of endometriosis and pathophysiological basis for endometriosis-associated painful symptoms are still uncertain. Little known about neuroendocrine (NE) cells in uterus.
Abstract Background Neoantigens can be differentially recognized by T cell receptor (TCR) as these sequences are derived from mutant proteins and unique to the tumor. The discovery of neoantigens is first key step for tumor-specific antigen (TSA) based immunotherapy. Based on high-throughput tumor genomic analysis, each missense mutation potentially give rise multiple neopeptides, resulting in a vast total number, but only small percentage peptides may achieve immune-dominant status with...
Abstract: Transcatheter arterial embolization (TAE) is widely used as an effective palliative treatment for hepatocellular carcinoma (HCC), and can prolong survival time. However, the high incidence of tumor recurrence metastasis after TAE still a major problem. Recent studies demonstrated that circulating cells (CTCs) contribute to metastasis. In this study, we tried clarify whether residual HCC increase by increasing number CTCs. An orthotopic liver model in Buffalo rat was established...
The purpose of this study was to retrospectively evaluate the therapeutic efficacy and safety ultrasound-guided percutaneous microwave ablation (MWA) combined with synchronous transcatheter arterial chemoembolization (TACE) in patients colorectal liver metastases (CRLM).A retrospective analysis performed 30 who were treated MWA TACE for cancer from November 2011 December 2014 Zhongshan Hospital, Fudan University. response tumor treatment evaluated by follow-up computed tomography and/or...
To investigate the diagnostic efficacy of diffusion kurtosis imaging (DKI) and conventional diffusion-weighted (DWI) for pathological grading.From December 2015 to January 2017, consecutive patients suspected having hepatocellular carcinoma (HCC) without prior treatment were prospectively enrolled in this study. MRI examinations performed before surgical treatment. HCC confirmed by pathology included The mean diffusivity (MD) values, (MK) apparent coefficient (ADC) calculated. differences...