A5018906122- Transplantation: Methods and Outcomes
- Tissue Engineering and Regenerative Medicine
- Mesenchymal stem cell research
- Cardiac Structural Anomalies and Repair
- Cardiac Ischemia and Reperfusion
- Glioma Diagnosis and Treatment
- Cancer, Stress, Anesthesia, and Immune Response
- Pluripotent Stem Cells Research
- Immune Cell Function and Interaction
- Fuel Cells and Related Materials
- RNA modifications and cancer
- Cancer Cells and Metastasis
- FOXO transcription factor regulation
- Seaweed-derived Bioactive Compounds
- Berberine and alkaloids research
- Cancer Mechanisms and Therapy
- Cardiac Fibrosis and Remodeling
- Phytoestrogen effects and research
- RNA Interference and Gene Delivery
- Galectins and Cancer Biology
- Hippo pathway signaling and YAP/TAZ
- Advanced Statistical Process Monitoring
- Cell death mechanisms and regulation
- Radiation Detection and Scintillator Technologies
- Congenital heart defects research
Qiqihar Medical University
2025
Sun Yat-sen Memorial Hospital
2018-2024
Sun Yat-sen University
2018-2024
Hohai University
2024
University of Cincinnati
2024
Sabin Vaccine Institute
2024
Wenzhou University
2016-2024
University of Cincinnati Medical Center
2017-2023
National Cancer Institute
2023
Guangdong Academy of Medical Sciences
2015-2023
Dysregulation of SF3A3 has been related to the development many cancers. Here, we investigated functional role in hepatocellular carcinoma (HCC). expression HCC tissues and cell lines was examined using RT-qPCR. Changes malignant behavior cells after downregulation were assessed by EdU, colony formation, flow cytometry, wound healing, Transwell invasion assays. Multiple datasets combined identify upstream modifiers SF3A3. The binding relationship between STIL FOXM1 explored co-IP assay,...
Cardiac transverse tubules (T-tubules) are anchored to sarcomeric Z-discs by costameres establish a regular spaced pattern. One of the major components is dystrophin-glycoprotein complex (DGC). Nevertheless, how assembly DGC coordinates with formation and maintenance T-tubules under physiological pathological conditions remains unclear.
Fibroblasts can be reprogrammed into cardiovascular progenitor cells (CPCs) using transgenic approaches, although the underlying mechanism remains unclear. We determined whether activation of endogenous genes such as Gata4, Nkx2.5, and Tbx5 rapidly establish autoregulatory loops initiate CPC generation in adult extracardiac fibroblasts a CRISPR system. The induced (>80%) showed phenotypic changes indicated by an Nkx2.5 cardiac enhancer reporter. characteristics were confirmed colony...
Glioma remains one of the most aggressive and lethal cancers in central nervous system. Temozolomide (TMZ) is commonly used chemotherapeutic agent gliomas. However, therapeutic benefits TMZ could be very limited all patients would finally suffer from tumor progression as tumors develop resistance to TMZ. In this study, we aim investigate underlying mechanism chemoresistance glioma cell line identify whether there still a close link between epithelial-mesenchymal transition (EMT) The...
Tetrandrine (TET), a bisbenzylisoquinoline alkaloid isolated from the root of Hang-Fang-Chi (Stephania tetrandra S. Moore), exhibits broad pharmacological effects, including antitumor activity in various malignant neoplasms. Recently, beneficial effects TET on cytotoxicity towards tumor cells, radiosensitization, circumventing multidrug resistance, normal tissue radioprotection, and antiangiogenesis have been examined extensively. However, potential molecular mechanisms effect glioma are yet...
It has been reported that CXCR4‐overexpressing mesenchymal stem cells (MSC CX4 ) can repair heart tissue post myocardial infarction. This study aims to investigate the MSCCX4‐derived paracrine cardio‐protective signaling in presence of Mesenchymal (MSCs) were divided into 3 groups: MSC only, , and CXCR4 gene‐specific siRNA‐transduced MSC. exposed hypoxia, then MSCs‐conditioned culture medium was incubated with neonatal adult cardiomyocytes, respectively. Cell proliferation–regulating genes...
Surgery-induced microglial activation is critical in mediating postoperative cognitive dysfunction (POCD) elderly patients, where the important protective effect of dexmedetomidine has been indicated. However, mechanisms action during neuroinflammatory response that underlies POCD remain largely unknown. We found lipopolysaccharide (LPS) induced substantial inflammatory responses primary and BV2 cells. The screening differentially expressed miRNAs revealed miR-103a-3p was downregulated these...
Colorectal cancer (CRC) is one of the most frequently diagnosed gastrointestinal malignancies worldwide and has high rates morbidity mortality. Propofol been reported to have certain anticancer properties. However, role mechanism propofol in CRC are not entirely clear. cells were treated with and/or LDH-overexpression plasmids, a mouse xenograft model was also established propofol. Cell viability, migration, invasion evaluated by CCK-8, wound healing, transwell assays; expression related...
We examined the effects of co-culturing CD4+ CD25+ Treg cells with sirolimus or cyclosporin A on cell proliferation and differentiation transforming growth factor-β (TGF-β) Foxp3 expression.CD4+ were harvested from mononuclear spleens C57BL/6 mice using immunomagnetic beads divided into control, sirolimus, cyclosporine groups.Following a 96-h co-culture, assayed by flow cytometry.FoxP3 TGF-β mRNA levels secretion reverse transcription polymerase chain reaction enzyme-linked immunosorbent...
Abstract Polysaccharides from Cordyceps militaris show multiple biological activities, such as antioxidation, antitumor, antivirus and immunomodulating properties, etc. The nutritional requirements for antioxidant polysaccharide bio-synthesis by submerged culture of C. were evaluated on the basis assay DPPH radical scavenging ability reducing power in this work. results showed best activity could be achieved when media consisted mannose, peptone, MgSO 4 , Na 2 HPO KH PO . Furthermore, main...
We sought to assess the protective effect of different doses Fingolimod (FTY720) in a rat model acute lung injury (ALI) induced by intratracheal instillation lipopolysaccharide (LPS) and explored underlying mechanisms. The ALI was established rats FTY720 (0.1 mg/kg, 0.2 0.5 1 or 2 mg/kg) were injected intraperitoneally. Lung computed tomography blood gas analyses performed at 6 h, 24 48 h after intraperitoneal injection, tissues extracted prepare paraffin sections for histopathological...
Abstract With the acceleration of demographic aging, heart failure has become a global public health issue. Left ventricular assist device (LVAD) provides therapeutic option serving as bridge to transplantation or destination treatment for end‐stage failure. However, neither molecular mechanism nor gene expression profile LVAD pathophysiology is well understood. Microarray dataset ( GSE21610 ) was retrieved from online database omnibus (GEO). Differentially expressed genes (DEGs) between...
Abstract Although stem/progenitor cell therapy shows potential for myocardial infarction repair, enhancing the therapeutic efficacy could be achieved through additional genetic modifications. HCLS1-associated protein X-1 (HAX1) has been identified as a versatile modulator responsible cardio-protective signaling, while its role in regulating stem survival and functionality remains unknown. In this study, we investigated whether HAX1 can augment protective of Sca1 + cardiac stromal cells...