A5102007785- Pharmacological Effects of Natural Compounds
- Nitric Oxide and Endothelin Effects
- Dermatology and Skin Diseases
- Adipose Tissue and Metabolism
- Epigenetics and DNA Methylation
- Genomics, phytochemicals, and oxidative stress
- Sirtuins and Resveratrol in Medicine
- Neuroscience and Neuropharmacology Research
- Angiogenesis and VEGF in Cancer
- Advanced biosensing and bioanalysis techniques
- Ginseng Biological Effects and Applications
- Diet, Metabolism, and Disease
- Fibroblast Growth Factor Research
- Natural product bioactivities and synthesis
- Traditional Chinese Medicine Analysis
- Eicosanoids and Hypertension Pharmacology
- Natural Antidiabetic Agents Studies
- RNA Interference and Gene Delivery
- Phytochemistry and biological activity of medicinal plants
- Dietary Effects on Health
- Cancer-related molecular mechanisms research
- Neurological Disease Mechanisms and Treatments
- Diet and metabolism studies
- Phytochemicals and Antioxidant Activities
- Exercise and Physiological Responses
Wuhan University
2016-2025
Zhejiang Sci-Tech University
2025
The Affiliated Yongchuan Hospital of Chongqing Medical University
2025
Chongqing Medical University
2025
Hainan Medical University
2024
Fourth Affiliated Hospital of China Medical University
2020-2024
China Medical University
2020-2024
Wuhan Donghu University
2024
Nanfang Hospital
2012-2023
Southern Medical University
2012-2023
Hepatic gluconeogenesis is a main source of blood glucose during prolonged fasting and orchestrated by endocrine neural pathways. Here we show that the hepatocyte-secreted hormone fibroblast growth factor 21 (FGF21) induces via brain-liver axis. Prolonged activation transcription peroxisome proliferator–activated receptor α (PPARα) in liver subsequent hepatic production FGF21, which enters into brain to activate hypothalamic-pituitary-adrenal (HPA) axis for release corticosterone, thereby...
Background— Fibroblast growth factor 21 (FGF21) is a metabolic hormone with pleiotropic effects on glucose and lipid metabolism insulin sensitivity. It acts as key downstream target of both peroxisome proliferator-activated receptor α γ, the agonists which have been used for lowering sensitization, respectively. However, role FGF21 in cardiovascular system remains elusive. Methods Results— The roles atherosclerosis were investigated by evaluating impact deficiency replenishment recombinant...
Exercise promotes adipose remodeling and improves obesity-induced metabolic disorders through mechanisms that remain obscure. Here, we identify the FGF21 signaling in tissues as an obligatory molecular transducer of exercise conferring its benefits mice. Long-term high fat diet-fed obese mice exhibit compromised effects exogenous on alleviation hyperglycemia, hyperinsulinemia, hyperlipidemia, accompanied with markedly reduced expression FGF receptor-1 (FGFR1) β-Klotho (KLB) tissues. These...
Dietary polysaccharides provide various beneficial effects for our health.
The aim of our study was to investigate the protective effects and underlying mechanisms myricetin, a bioactive food compound, on brain injury neurological deficits after ischemic stroke. Treatment myricetin significantly attenuated oxygen-glucose deprivation (OGD)-induced cell death in SHSY5Y cells vitro. In rat model cerebral ischemia, administered intragastrically at 2 h before every day middle artery occlusion (MCAO). were evaluated by various biochemical assays neurobehavioral tests....
Conjugated linoleic acid (CLA), a bioactive substance predominantly found in ruminant products, improves insulin resistance and exhibits anti-inflammatory activity. The chief objective of the study is to investigate effects potential mechanisms CLA on high fructose-induced hyperuricemia renal inflammation.Hyperuricemia inflammation are induced rats by 10% fructose. Hyperuricemia, resistance, evaluated. potently ameliorates with significantly reduces levels factors serum kidney. It reverses...
Disruption of the blood-brain barrier (BBB) is a major pathogenic mechanism neurological dysfunction and death after ischemic stroke. The aim our study was to investigate effect procyanidin B2 (PB), bioactive food compound, on BBB disruption induced by stroke explore underlying mechanism.PB administrated intragastrically once day starting at 3 h transient middle cerebral artery occlusion (MCAO). PB treatment significantly decreased infarction volume, brain edema, deficits MCAO. prevented...
SARS-CoV-2 is highly infectious, and infection by this virus results in COVID-19, manifesting predominantly symptoms the lower respiratory system. Detection of viral genomic materials RT-PCR gold standard for diagnosis. Suspected COVID-19 patients who had a documented history exposure exhibited symptoms, but did not have positive PCR test results, were generally self-quarantined with prescriptions aiming to help attenuate their symptoms. These are however neither specific nor effective...
Both human and animal experiments have demonstrated that energy metabolism dysfunction in neurons after seizures is associated with an imbalance mitochondrial fusion/fission dynamics. Effective neuronal dynamics regulation strategies remain elusive. Nicotinamide mononucleotide (NMN) can ameliorate functional oxidative stress age-related diseases. But whether NMN improves to exert anti-epileptic effects unclear. This study aims clarify if protect from pentylenetetrazole (PTZ) or Mg
Treatment of human immunodeficiency virus (HIV)-infected patients with HIV protease inhibitors (PIs) has been associated serious lipid disturbances. However, the incidence and degree impaired metabolism observed in clinic vary considerably between individual PIs. Our previous studies demonstrated that PIs differ their ability to increase levels transcriptionally active sterol regulatory element-binding proteins (SREBPs), activate unfolded protein response (UPR), induce apoptosis, promote...
Isofraxidin (IF) is a coumarin compound produced in the functional foods<italic>Siberian ginseng</italic>and<italic>Apium graveolens</italic>.
The aim of the present research was to study protective effects and underlying mechanisms apigenin on<sc>d</sc>-galactose-induced aging mice.
Dear Editor: The coronavirus disease 2019 (COVID-19) caused by the highly infectious severe acute respiratory syndrome 2 (SARS-CoV-2) had spread to every continent, with more than 4 million confirmed cases all over world May 9, 2020. typical clinical syndromes of COVID-19 involve viral pneumonia associated distress (ARDS), which is leading cause morbidity and mortality at advanced stage.1, manifests a complex epidemiology pathophysiology2, 3; infection not only affects system but also causes...