A5100358282- Vestibular and auditory disorders
- Hearing, Cochlea, Tinnitus, Genetics
- Ear Surgery and Otitis Media
- Glaucoma and retinal disorders
- Ophthalmology and Eye Disorders
- Plant Stress Responses and Tolerance
- Tracheal and airway disorders
- Inflammatory mediators and NSAID effects
- Garlic and Onion Studies
- RNA modifications and cancer
- Plant Reproductive Biology
- Peripheral Nerve Disorders
- Redox biology and oxidative stress
- Protein Tyrosine Phosphatases
- Bone Metabolism and Diseases
- Drug-Induced Hepatotoxicity and Protection
- Plant-Microbe Interactions and Immunity
- Aluminum toxicity and tolerance in plants and animals
- melanin and skin pigmentation
- Cancer Cells and Metastasis
- Microtubule and mitosis dynamics
- Cerebral Venous Sinus Thrombosis
- Congenital Ear and Nasal Anomalies
- Insect-Plant Interactions and Control
- Endoplasmic Reticulum Stress and Disease
Shandong University
2016-2025
Shandong Provincial Hospital
2014-2025
Hangzhou Normal University
2023-2024
Yuhuangding Hospital
2024
Mayo Clinic Health System
2024
Yunnan University
2024
Shandong First Medical University
2023-2024
Shanxi Agricultural University
2018-2023
Shandong Institute of Metrology
2019-2022
Shenyang Pharmaceutical University
2021-2022
Hearing loss is the most common sensory disorder in humans, and a significant number of cases due to ototoxicity drugs such as cisplatin that cause hair cell (HC) damage. Thus, there great interest finding agents mechanisms protect HCs from ototoxic drug It has been proposed epigenetic modifications are related inner ear development play role HC protection regeneration; however, whether m6A modification ethyl ester form meclofenamic acid (MA2), which highly selective inhibitor FTO (fatmass...
Ménière's disease, a multifactorial disorder of the inner ear, is characterized by severe vertigo episodes and hearing loss. Although role immune responses in disease has been proposed, precise mechanisms remain undefined. Here, we show that downregulation serum/glucocorticoid-inducible kinase 1 associated with activation NLRP3 inflammasome vestibular-resident macrophage-like cells from patients. Serum/glucocorticoid-inducible depletion markedly enhances IL-1β production which leads to...
Abstract Meniere’s disease (MD) is a disorder of the inner ear characterized by episodes spontaneous vertigo, fluctuating hearing loss, and tinnitus. Recent studies have demonstrated that IgE may play role in pathogenesis MD. Patients with MD (n = 103), acoustic neuroma 5), healthy subjects 72) were recruited into study. Serum from participants was analyzed for type 2–related cytokines. CD23 expression levels vestibular end organs patients, C57BL/6 mice, or mouse HEI-OC1 cells analyzed....
ABSTRACT The inner ear is a critical sensory organ regulated by the immune system to maintain balance and respond external stimuli. Immune cells like macrophages, lymphocytes, neutrophils, natural killer play important roles in immunity. Inflammatory mediators, such as cytokines chemokines, along with signaling pathways NF‐κB, MAPK, PI3K/AKT, regulate responses ear. Complement activation inflammatory vesicles further affect immune‐related pathology, causing damage epithelium, neurons, blood...
Despite major scientific advances in its prevention, treatment and care, hypertension remains a serious condition that might lead to long-term complications such as heart disease stroke.
Butein, a member of the chalcone family, is potent anticarcinogen against multiple cancers, but its specific anti-NSCLC mechanism remains unknown.The present study examined effects butein treatment on NSCLC cell lines and xenografts.Butein markedly decreased viability; inhibited adhesion, migration, invasion, colony forming ability; induced apoptosis G2/M phase arrest in cells.Moreover, significantly PC-9 xenograft growth.Both vivo vitro studies verified that exerted effect through...
Abstract Background Plant cell wall polysaccharide composition varies substantially between species, organs and genotypes. Knowledge of the structure these polysaccharides, accompanied by a suite well characterised glycosyl hydrolases will be important for success lignocellulosic biofuels. Current methods used to characterise enzymatically released plant oligosaccharides are relatively slow. Results A method software was developed allowing use DNA sequencer profile derived from...
CCN4, also termed WNT-inducible signaling pathway protein-1 (WISP-1), has important roles in inflammation and tissue injury. This study aimed to investigate the effect of CCN4 inhibition using monoclonal anti-CCN4 antibody (CCN4mAb) on liver injury fibrosis a mouse model fibrosis.The was induced by carbon tetrachloride (CCl4). Mice received vehicle (saline/olive oil) subcutaneous injection, CCl4 injection or (subcutaneous) plus CCN4mAb injection. The pro-inflammatory pro-fibrotic factors...
Cisplatin is an anti-cancer drug that causes oxotoxic side effects such as impairment of inner ear function and hearing loss. We aimed to investigate the allicin against cisplatin-induced stria vascularis damage in mice, clarify mechanism underlying protective ototoxicity. Stria injury was induced mice by intraperitoneal injection cisplatin, which significantly prevented pretreatment with allicin. Allicin not only reduced cisplatin-activated expression cleaved caspase-3 marginal cells,...
INTRODUCTION:Meniere's disease is a common chronic inner ear disease. Because the definitive pathogenesis still unknown, there currently no cure for this disorder. Semicircular canal plugging (SCP), first used to treat patients with intractable benign paroxysmal positional vertigo, has since been applied peripheral vertigo. This study was aimed explore long-term efficacy of triple semicircular (TSCP) in treatment Meniere's (MD) so as provide new method framework MD. METHODS:Three hundred and...
Objectives The study goals were to compare the long‐term efficacy of semicircular canal plugging (SCP) with labyrinthectomy in treatment advanced Meniere's disease (MD). Study Design A retrospective study. Setting Single tertiary medical center. Methods total 116 MD patients (TSCP group 90; 26) complete documents Shandong Provincial ENT Hospital, from March 2017 2019 retrospectively analyzed, including a battery auditory and vestibular function tests, recovery time imbalance level scores...
Mammalian SPAG6 protein is localized to the axoneme central apparatus, and it required for normal flagella cilia motility. Recent studies demonstrated that also regulates ciliogenesis polarity in epithelial cells of brain ventricles trachea. Motile are present middle ear Eustachian tubes, where ciliary system participates movement serous fluid mucus ear. Cilia defects associated with otitis media (OM), presumably due an inability efficiently transport fluid, particles including...
Chloride (Cl−) is considered a crucial nutrient for plant growth, but it can be challenge under saline conditions. Excessive accumulation of Cl− in leaves cause toxicity. channels (CLCs) are expressed the inner membranes cells and function as essential exchangers or channels. In response to salt stress plants, CLCs play role, CLC proteins assist maintaining intracellular homeostasis by sequestering into vacuoles. Sodium chloride (NaCl) primary substance responsible causing salt-induced...
The Shenque acupoint is located in the umbilicus of human body. In body meridians, can regulate functions. was one important acupuncture acupoints for treatment insomnia. However, effect linalool applied at to improve sleep unknown. This study explored hypnotic and sedative effects main component lavender, linalool, on mice rats. latency duration were studied with supra-threshold dose pentobarbital sodium, rate sub-threshold sodium. order further feasibility superiority administered...
Objective We investigated correlations among clinical features, degree of inner ear endolymphatic hydrops (EH), and hippocampal volume (HV) in different stages Meniere's disease (MD). Methods From February 2021 to April 2022, data were collected from 99 patients (39 males, 60 females, mean age: 50.4 ± 10.0 [range: 26–69] years) with unilateral MD admitted the Department Vertigo Disease Shandong ENT Hospital. The left right ears affected 64 35 patients, respectively. There 50 49 cases early...