A5100604952- Lung Cancer Research Studies
- Antibiotic Resistance in Bacteria
- Bacteriophages and microbial interactions
- Lung Cancer Treatments and Mutations
- Bacterial biofilms and quorum sensing
- Microbial Community Ecology and Physiology
- Plant tissue culture and regeneration
- Plant Pathogens and Fungal Diseases
- Brain Metastases and Treatment
- Vibrio bacteria research studies
- Pharmaceutical and Antibiotic Environmental Impacts
- Aquaculture disease management and microbiota
- Genomics and Phylogenetic Studies
- Esophageal Cancer Research and Treatment
- Gut microbiota and health
- Lung Cancer Diagnosis and Treatment
- Service-Oriented Architecture and Web Services
- Pharmacological Effects of Natural Compounds
- Legume Nitrogen Fixing Symbiosis
- Business Process Modeling and Analysis
- Dental Trauma and Treatments
- Light effects on plants
- Cancer Immunotherapy and Biomarkers
- Bacterial Genetics and Biotechnology
- Natural product bioactivities and synthesis
Chinese Academy of Agricultural Sciences
2016-2024
Shandong University
2010-2024
Shandong Provincial Hospital
2010-2024
Sweet Potato Research Institute
2023-2024
Institute of Quality Standards and Testing Technology for Agro Products
2024
Anderson University - South Carolina
2024
Experimental Station
2023
Chinese PLA General Hospital
2023
Shanghai Ocean University
2023
Jinan Central Hospital
2023
Abstract Knowledge about the modulation of gut microbiota improves our understanding underlying mechanism by which probiotic treatment benefits chickens. This study examined effects Bacillus subtilis DSM 32315 on intestinal structure and microbial composition in broilers. Broiler chicks were fed basal diets without or with B . supplementation (1.0 × 10 9 spores/kg diet). Supplemental increased average body weight daily gain, as well elevated villus height to crypt depth ratio ileum...
ABSTRACT The inner ear is a critical sensory organ regulated by the immune system to maintain balance and respond external stimuli. Immune cells like macrophages, lymphocytes, neutrophils, natural killer play important roles in immunity. Inflammatory mediators, such as cytokines chemokines, along with signaling pathways NF‐κB, MAPK, PI3K/AKT, regulate responses ear. Complement activation inflammatory vesicles further affect immune‐related pathology, causing damage epithelium, neurons, blood...
Two new 30-noroleanane triterpenes, 2α,3β,20α-trihydroxy-30-norolean-12-en-28-oic acid (1), 2α,3β-dihydroxy-23-oxo-30-norolean-12,20(29)-dien-28-oic (2), were isolated from the pericarps of Akebia trifoliata, together with four known ones, 3β-akebonoic (3), 2α,3β-dihydroxy-30-noroleana-12,20(29)-dien-28-oic (4), 3α-akebonoic (5) and quinatic (6). Their structures established on basis detailed spectroscopic analysis, they all A. trifoliata for first time. Compounds 3−6 showed in vitro...
The rice blast pathogen, Magnaporthe oryzae, spreads through spores and invades appressoria. Melanin is necessary for an appressorium to penetrate plant cells, but there are many unknown aspects of its role in fungal conidiation. In this study, we confirmed that melanin promotes spore production M. effect related the background content wild-type strains. 70-15 strain with low aerial hyphae, increased synthesis promoted sporulation. contrast, Guy11 strain, which has higher content, did not...
Controversial value of prophylactic cranial irradiation (PCI) in NSCLC terms survival benefit prompted us to explore the possible risk factors for brain metastasis (BM) during course EGFR-TKIs therapy from EGFR-mutated advanced lung adenocarcinoma and identify potential population most likely PCI, because BM remains a therapeutically challenging issue. We retrospectively reviewed records 134 patients with between 2008 2012. The cumulative incidence was calculated by Kaplan-Meier method,...
Tartary buckwheat is a type of cultivated medicinal and edible crop with good economic nutritional value. Knowledge the final fruit size critical to its yield increase. In this study, development two species in Polygonaceae was analyzed. During development, size/weight, contents auxin (AUX)/abscisic acid (ABA), number cells, changes embryo were measured observed; materials compared determine related mechanisms that affected potential factors regulated size. The early events during...
The anticariogenic activity of the extract Glycyrrhiza uralensis (licorice) has been well documented. We recently developed an herbal lollipop containing licorice extracts with Glycyrrhizol A, compound displaying strong antimicrobial against Streptococcus mutans. Preliminary testing showed that reduced salivary S. mutans counts in vivo. In this study, we aimed to further test efficacy for reducing levels, and investigate its impact on microbiome. Using a well-established vitro oral...
The emergence of multidrug resistance (MDR) in Proteus mirabilis clinical isolates is a growing public health concern and has serious implications for wildlife. What the role wildlife been become one hot issues disseminating antimicrobial resistance. Here, 54 P. from 12 different species were identified. Among them, 25 determined to be MDR by profile susceptibility; 10 subjected comparative genomic analysis whole genome sequencing. Comprehensive showed that chromosome mainly carries...
We isolated eight tigecycline-resistant
Abstract Background Leptomeningeal metastasis (LM) is a detrimental complication of advanced non‐small‐cell lung cancer (NSCLC), and the optimal therapeutic approach for LM patients in shortage. This retrospective study aimed to investigate clinical features prognostic factors NSCLC with LM. Methods We retrospectively reviewed medical records at Shandong Cancer Hospital Institute between July 2014 March 2018. Identified cases had pathology‐proven either positive cerebrospinal fluid cytology...
Summary Myxococcus xanthus kills susceptible bacteria using myxovirescin A (TA) during predation. However, whether prey cells in nature can escape M. by developing resistance to TA is unknown. We observed that many field‐isolated Bacillus licheniformis strains could survive encounters with , which was correlated their resistance. glycoside identified the broth of predation‐resistant B. J32 co‐cultured and a glycosyltransferase gene ( yjiC ) up‐regulated after addition TA. Hetero‐expressed...
To investigate the impact of plasmid-borne oqxAB genes on development fluoroquinolone resistance, mutations and bacterial fitness in Escherichia coli .MICs mutation prevention concentrations were compared among E. strain TOP10 two corresponding transformants harbouring OqxAB-encoding plasmids. Mutants selected by serial passages with 0.5-fold MIC ciprofloxacin, randomly to determine mutations. Bacterial was evaluated competition assays vitro vivo .The -carrying plasmids contributed a...
Myxococcus xanthus belongs to the delta class of proteobacteria and is notable for its complex life-style with social behaviors relatively large genome. Although previous observations have suggested existence horizontal gene transfer in M. xanthus, ability take up exogenous DNA via natural transformation has not been experimentally demonstrated. In this study, we achieved using autonomously replicating myxobacterial plasmid pZJY41 as donor DNA. exopolysaccharide (EPS) was shown be an...
Abstract Myxococcus xanthus performs coordinated social motility of cell groups through the extension and retraction type IV pili (TFP) on solid surfaces, which requires both TFP exopolysaccharides (EPS). By submerging cells in a liquid medium containing 1% methylcellulose, M. TFP-driven was induced isolated independently EPS. We measured analyzed movements using community tracking algorithms, combine single-cell resolution with statistics from large sample populations. Cells without...
Phosphate-solubilizing bacteria (PSB) increase phosphate bioavailability, thereby reducing the application frequency of chemical fertilizers in production Nicotiana tabacum (tobacco).In this study, PSB were isolated from tobacco plants for fi rst time.These screened vitro their ability to solubilize inorganic P (Pi) when grown association with plants.Thirty-six i and indolyl-3-acetic acid siderophore-producing capabilities.In addition, all 36 strains had a partial fragment 16S rRNA gene...
This study aimed to compare the efficacy of nimotuzumab (Nimo) versus cetuximab (C225) plus concurrent chemoradiotherapy (CCRT) in locally advanced esophageal squamous cell carcinoma (LA-ESCC). A total 95 patients with LA-ESCC were retrospectively reviewed, including 65 Nimo and 30 C225. The results showed that ORR (61.0%; CR 22.0%, 13/59; PR 39.0% 23/59) was slightly higher than C225 (43.5%; 8.7%, 2/23; 34.8%, 8/23) but without significant difference (p = 0.81). DCR 79.7% vs. 73.9% C225,...
Abstract Objective: We investigated the correlation between number of circulating tumor cells (CTCs) and whole-body metabolic volume (WBMTV) measured by 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT). The aim was to evaluate value incorporation CTC WBMTV in prognostic prediction stage III small-cell lung cancer (SCLC). Methods: One hundred twenty-nine patients were enrolled this study. All treated with four cycles a platinum-based regimen concurrent...
Vibrio parahaemolyticus (V. parahaemolyticus) is considered the most concerning pathogen for seafood. Like other pathogens in food samples, its gene detection suffers from a problem of background interference when isothermal methods are used. The sensitivity and specificity greatly decrease due to large amounts genome. Here we describe novel technology based on target-cyclized rolling circle amplification combined with loop-mediated (tRCA-lamp). By avoiding unexpected ligation, short dynamic...
Plant transient expression using virus-based vectors is advantageous when high level of gene desired within a short time. In this study, new system, named "air-brush," has been developed to facilitate scale-up production recombinant proteins in plants. GFP was expressed successfully Nicotiana benthamiana (Nb) plants by air-brushing an Agrobacterium suspension that contained the TMV-based vector p35S-30B-GFP. Key factors influencing were optimized, including cell density, seedling age, and...