A5006024055- Food Allergy and Anaphylaxis Research
- Eosinophilic Esophagitis
- Allergic Rhinitis and Sensitization
- COVID-19 Clinical Research Studies
- Enzyme Catalysis and Immobilization
- Asthma and respiratory diseases
- Microbial Metabolic Engineering and Bioproduction
- Immune Cell Function and Interaction
- Ideological and Political Education
- SARS-CoV-2 and COVID-19 Research
- Eosinophilic Disorders and Syndromes
- Biofuel production and bioconversion
- Long-Term Effects of COVID-19
- Neonatal Respiratory Health Research
- Fungal Biology and Applications
- Probiotics and Fermented Foods
- IL-33, ST2, and ILC Pathways
- Respiratory and Cough-Related Research
- Mycorrhizal Fungi and Plant Interactions
- Pediatric health and respiratory diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Gastric Cancer Management and Outcomes
- Metabolomics and Mass Spectrometry Studies
- COVID-19 and healthcare impacts
- Cardiovascular Function and Risk Factors
Stanford University
2017-2024
Second Affiliated Hospital of Nanchang University
2023-2024
Nanchang University
2023-2024
First Affiliated Hospital of Fujian Medical University
2020-2023
Fujian Medical University
2020-2023
Nanjing Tech University
2017-2023
Jiangsu Academy of Safety Science & Technology
2023
Shanghai Tenth People's Hospital
2022-2023
Tongji University
2022-2023
Children's Hospital of Los Angeles
2012-2022
Our understanding of protective versus pathological immune responses to SARS-CoV-2, the virus that causes coronavirus disease 2019 (COVID-19), is limited by inadequate profiling patients at extremes severity spectrum. Here, we performed multi-omic single-cell 64 COVID-19 across full range severity, from outpatients with mild fatal cases. transcriptomic, epigenomic, and proteomic analyses revealed widespread dysfunction peripheral innate immunity in severe COVID-19, including prominent...
At this stage in the COVID-19 pandemic, most infections are "breakthrough" that occur individuals with prior severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) exposure. To refine long-term vaccine strategies against emerging variants, we examined both innate and adaptive immunity breakthrough infections. We performed single-cell transcriptomic, proteomic, functional profiling of primary to compare immune responses from unvaccinated vaccinated during SARS-CoV-2 Delta wave....
B cells in human food allergy have been studied predominantly the blood. Little is known about IgE+ or plasma tissues exposed to dietary antigens. We characterized clones blood, stomach, duodenum, and esophagus of 19 peanut-allergic patients, using high-throughput DNA sequencing. allergic patients are enriched stomach a cell phenotype. Clonally related non-IgE-expressing frequencies suggest local isotype switching, including transitions between IgA IgE isotypes. Highly similar antibody...
Abstract Knowledge about the modulation of gut microbiota improves our understanding underlying mechanism by which probiotic treatment benefits chickens. This study examined effects Bacillus subtilis DSM 32315 on intestinal structure and microbial composition in broilers. Broiler chicks were fed basal diets without or with B . supplementation (1.0 × 10 9 spores/kg diet). Supplemental increased average body weight daily gain, as well elevated villus height to crypt depth ratio ileum...
Atrial remodeling is a major contributor to the onset of atrial fibrillation (AF) after myocardial infarction (MI). Tripartite motif-containing protein 21 (TRIM21), an E3 ubiquitin ligase, associated with pathological cardiac and dysfunction. However, role TRIM21 in postmyocardial subsequent AF remains unclear. This study investigated post using knockout mice explored underlying mechanisms by overexpressing HL-1 myocytes lentiviral vector. The expression left atrium mouse MI model was...
Idiopathic pulmonary fibrosis (IPF) is a devastating disease, and its pathogenic mechanisms remain incompletely understood. Peroxisomes are known to be important in ROS proinflammatory lipid degradation, their deficiency induces liver fibrosis. However, altered peroxisome functions IPF pathogenesis have never been investigated. By comparing peroxisome-related protein gene expression lung tissue isolated fibroblasts between human control patients, we found that lungs exhibited significant...
Reciprocal interactions between lung mesenchymal and epithelial cells play essential roles in organogenesis homeostasis. Although the molecular markers related animal models that target are relatively well studied, of genetic tools to and/or manipulate gene expression a mesenchyme-specific manner not available, which becomes critical barrier study biology pulmonary diseases. We have identified mouse Tbx4 enhancer contains conserved DNA sequences across many vertebrate species with or...
Pulmonary arterial hypertension (PAH) is a fatal disease characterized by profound vascular remodeling in which pulmonary arteries narrow because of medial thickening and occlusion neointimal lesions, resulting elevated resistance right heart failure. Therapies targeting the neointima would represent significant advance PAH treatment; however, our understanding cellular events driving formation, molecular pathways that control them, remains limited. We comprehensively map stepwise robust,...
Over 40,000 cases of coronavirus (CoV) disease 2019 (COVID-19) have been confirmed in China. The causative agent, novel CoV (2019-nCoV), has spread rapidly to more than 25 countries worldwide. Human-to-human transmission accounted for most the infections outside Wuhan. Most studies date on COVID-19 focused etiology and genomics 2019-nCoV, with few reports epidemiologic clinical characteristics infected patients.We report early features 26 patients who were admitted Liaocheng Infectious...
Rationale: Oral immunotherapy (OIT) is an emerging treatment for food allergy. While desensitization achieved in most subjects, many experience gastrointestinal symptoms and few develop eosinophilic disease. It unclear whether these subjects have subclinical eosinophilia (GE) at baseline. We aimed to evaluate the presence of GE with allergy before peanut OIT. Methods: performed baseline esophagogastroduodenoscopies on twenty-one adults undergoing Subjects completed a detailed symptom...
The elongation growth of the mushroom stipe is a characteristic but not well-understood morphogenetic event basidiomycetes. We found that extending native cell walls Coprinopsis cinerea were associated with release N-acetylglucosamine and chitinbiose chitinase activity. Two chitinases among all detected from C. cinerea, ChiE1 ChiIII, reconstituted heat-inactivated wall extension released chitinbiose. Interestingly, both ChiIII hydrolyze insoluble crystalline chitin powder, while other do...
Due to the heavy metabolic burden and low efficiency of microbial pure cultures during biotechnological process for biochemicals production, researchers have focused on cocultivation systems, which can complete more complicated tasks through labor division. However, one problem hindering application system is instability. Cell immobilization technology provides a promising solution, not only allows cell be used multiple times but also relieves feedback inhibition toward cells caused by...
<bold>Objective:</bold> This study aimed to identify additional characteristics and features of coronavirus disease (COVID-19) by assessing the clinical courses among COVID-19 patients in a region outside Hubei province. <bold>Methods:</bold> We analyzed retrospective data regarding general characteristics, epidemiologic history, underlying chronic diseases, symptoms complications, chest computed tomography findings, biochemical monitoring, severity, treatments, outcomes 37 adult with...
Background: Accumulating evidence suggests that coronavirus disease 2019 (COVID-19) is associated with hypercoagulative status, particularly for critically ill patients in the intensive care unit. However, prevalence of venous thromboembolism (VTE) these under routine prophylactic anticoagulation remains unknown. A meta-analysis was performed to evaluate VTE by pooling results observational studies. Methods: Observational studies reported COVID-19 were identified searching PubMed and Embase...
Background Handedness refers to the lateral preference of using one hand more than other. Surgeon handedness has been widely discussed in operative surgery and could cause clinical discrepancy. However, use proximal femoral nail antirotation (PFNA) for treatment intertrochanteric femur fracture (IFF), effect on outcomes is easily overlooked. In fact, when right-handed surgeons operate right-sided IFF patients, due specific nature surgical site, they have their left perform opening at end...
Abstract Aging is intimately linked to system‐wide metabolic changes that can be captured in blood. Understanding biological processes of aging humans could help maintain a healthy trajectory and promote longevity. We performed untargeted plasma metabolomics quantifying 770 metabolites on cross‐sectional cohort 268 individuals including 125 twin pairs covering human lifespan (from 6 months 82 years). Unsupervised clustering profiles revealed main trajectories throughout life were associated...