A5024615687- Diabetes Management and Research
- Viral Infections and Immunology Research
- Diabetes and associated disorders
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Pancreatic function and diabetes
- Monoclonal and Polyclonal Antibodies Research
- Immunodeficiency and Autoimmune Disorders
- Thyroid Disorders and Treatments
- Diabetes Treatment and Management
- Digestive system and related health
- Eosinophilic Disorders and Syndromes
- Cardiovascular Function and Risk Factors
- Eosinophilic Esophagitis
- Effects and risks of endocrine disrupting chemicals
- Neonatal Health and Biochemistry
- Carcinogens and Genotoxicity Assessment
- Genetically Modified Organisms Research
- Sexual Differentiation and Disorders
- Congenital Diaphragmatic Hernia Studies
- Cardiac Valve Diseases and Treatments
- Microscopic Colitis
- Urologic and reproductive health conditions
- Metabolism, Diabetes, and Cancer
- Growth Hormone and Insulin-like Growth Factors
- Gastrointestinal disorders and treatments
University Hospital Hradec Králové
2015-2025
Charles University
2013-2025
Cornell University
2024
University of Hradec Králové
2003-2023
Siemens Healthcare (Germany)
2017-2019
Beaumont Hospital, Royal Oak
2010-2012
Royal Hospital for Children
2010
Mayo Clinic
2008-2009
International Life Sciences Institute
1993-2009
Paracelsus Medizinische Privatuniversität
2009
Although endoscopic examination in patients with bleeding of the upper gastrointestinal tract has improved diagnostic accuracy, it not been useful predicting clinical outcome and shown to improve patients' prognoses. This article describes a subgroup acute whose can be predicted at time endoscopy. In 28 317 who underwent endoscopy, "visible vessel" was seen an ulcer presumed site. All were later recommended for operation because recurrent (86 per cent) or uncontrolled (14 hemorrhage....
<h3>Background</h3> Chronic mucocutaneous candidiasis disease (CMCD) may result from various inborn errors of interleukin (IL)-17-mediated immunity. Twelve the 13 causal mutations described to date affect coiled-coil domain (CCD) <i>STAT1</i>. Several mutations, including R274W in particular, are recurrent, but underlying mechanism is unclear. <h3>Objective</h3> To investigate and describe nine patients with CMCD Eastern Central Europe, assess biochemical impact <i>STAT1</i> determine...
Abstract Growth hormone (GH) insensitivity syndrome (GHIS) is a rare clinical condition in which production of insulin-like growth factor 1 blunted and, consequently, postnatal impaired. Autosomal-recessive mutations signal transducer and activator transcription (STAT5B), the key for GH, cause severe GHIS with additional characteristics immune often fatal, pulmonary complications. Here we report dominant-negative, inactivating STAT5B germline patients failure, eczema, elevated IgE but...
When mice of certain strains are infected with the cardiotropic virus coxsackievirus B3 or immunized mouse cardiac myosin, myocarditis, accompanied by immune recognition myocardium, ensues. That both target organ injury and peripheral immunization lead to similar disease manifestations raise questions about role tissue damage in eliciting autoantibodies. A/J were myosin killed at weekly intervals for 4 wk. A portion each heart was examined histologically evidence myocarditis antibodies...
X-linked lissencephaly with abnormal genitalia (XLAG) is a distinct form of associated absent corpus callosum. Recently, forms syndromic and nonspecific mental retardation have been found to be mutations in the <i>Aristaless</i>-related homeobox gene <i>ARX</i>. The authors assessed <i>ARX</i> as candidate for XLAG genetic analysis neuronal migration disorders two different point pedigrees affecting homeodomain protein, confirming that causative XLAG.
The recommended threshold for the time spent on continuous glucose monitoring (CGM) is established at 70%. However, outcomes in children with type 1 diabetes (CwD) using CGM a different proportion of within this have not been evaluated yet. study aims to compare glycemic parameters among CwD who 70%-89% and ≥90% population-wide data from Czech national pediatric registry ČENDA.
Subsequent to early life feeding issues, children with Prader-Willi syndrome (PWS) develop hyperphagia and severe obesity. Growth hormone (GH) therapy has been approved in PWS improve growth, body composition, BMI. We aimed clarify the role of age at GH onset on growth BMI trajectories PWS. analyzed height 114 patients (58 boys) from REPAR - Czech national registry. From them, 69 started prior 2 y/o (age 0.8 ± 0.4 years; mean SD; early-onset group [EO]), 45 later 7.1 4.1 late-onset [LO])....
OBJECTIVE Hepatocyte nuclear factor-1A maturity-onset diabetes of the young (HNF1A-MODY) is a monogenic form caused by heterozygous mutations in HNF1A. Currently, history diabetic ketoacidosis (DKA) an exclusion criterion for genetic testing MODY. HISTORY AND EXAMINATION In this article, we describe two unrelated patients aged 17 and 24 years with severe DKA developed several after diagnosis HNF1A-MODY. INVESTIGATION Both were treated insulin, but their metabolic control was poor (HbA1c 15%,...
Background To explore type 1 diabetes incidence patterns during the pandemic years 2020 and 2021 in Czechia, to compare them trends from previous decade, test its association with indicators of containment measures severity (school closing all-cause excess mortality). Methods The Czech Childhood Diabetes Register is a population-based register recording patients age 0–14.99 at onset. Type period (April 2020–end observation Dec 2021) was compared by Poisson regression models over past decade...
Objective. Recent clinical and echocardiographic studies have identified dilated cardiomyopathy in 10–20% of HIV-infected adults. The purpose this study was to determine the role cardiotropic cytomegalovirus (CMV) infection development HIV-associated cardiomyopathy. Design. We generated sense antisense digoxigenin-labeled riboprobes derived from CMV immediate-early (IE) delayed-early (DE) genes applied them retrospectively endomyocardial biopsy samples control autopsy cardiac patients....
Abstract Experimental autoimmune myocarditis (EAM) is elicited in certain strains of mice by immunizing with mouse cardiac myosin. Concomitant the onset myocardial inflammation induction circulating IgG antibodies to To further examine role myosin disease, both EAM-susceptible (A/J) and EAM-resistant (B10.A) were immunized emulsified CFA examined for deposition. Myocarditis was common susceptible, but not resistant strain mice. deposition extensive A/J mice, modest B10.A when compared...
Objective Increased access to modern technologies is not always accompanied by a decrease in HbA1c. The aim of this study was identify changes the proportion continuous glucose monitoring (CGM) users since 2017, when general reimbursement for CGM became effective Czechia, and test whether HbA1c associated with percentage time spent on CGM. Research design methods All T1D children Czech national ČENDA registry (3197 children) were categorized according their associations age, sex, center...