Kathleen D. Press
A5064975456- COVID-19 Clinical Research Studies
- Malaria Research and Control
- SARS-CoV-2 and COVID-19 Research
- Immune Cell Function and Interaction
- Long-Term Effects of COVID-19
- Mosquito-borne diseases and control
- HIV Research and Treatment
- Complement system in diseases
- Immune responses and vaccinations
- T-cell and B-cell Immunology
- Immune cells in cancer
- Pneumonia and Respiratory Infections
- Bacterial Identification and Susceptibility Testing
- SARS-CoV-2 detection and testing
- Microplastics and Plastic Pollution
- Aquaculture disease management and microbiota
- biodegradable polymer synthesis and properties
- Vector-borne infectious diseases
- vaccines and immunoinformatics approaches
- Antimicrobial agents and applications
- Invertebrate Immune Response Mechanisms
- Hemoglobinopathies and Related Disorders
- Cytomegalovirus and herpesvirus research
- COVID-19 Impact on Reproduction
- Antimicrobial Resistance in Staphylococcus
Stanford University
2018-2024
Harvard University
2015-2019
Wellcome Centre for Molecular Parasitology
2017-2019
University of Glasgow
2017-2019
Yale University
2011
ABSTRACT Bioremediation is an important approach to waste reduction that relies on biological processes break down a variety of pollutants. This made possible by the vast metabolic diversity microbial world. To explore this for breakdown plastic, we screened several dozen endophytic fungi their ability degrade synthetic polymer polyester polyurethane (PUR). Several organisms demonstrated efficiently PUR in both solid and liquid suspensions. Particularly robust activity was observed among...
Our understanding of protective versus pathological immune responses to SARS-CoV-2, the virus that causes coronavirus disease 2019 (COVID-19), is limited by inadequate profiling patients at extremes severity spectrum. Here, we performed multi-omic single-cell 64 COVID-19 across full range severity, from outpatients with mild fatal cases. transcriptomic, epigenomic, and proteomic analyses revealed widespread dysfunction peripheral innate immunity in severe COVID-19, including prominent...
At this stage in the COVID-19 pandemic, most infections are "breakthrough" that occur individuals with prior severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) exposure. To refine long-term vaccine strategies against emerging variants, we examined both innate and adaptive immunity breakthrough infections. We performed single-cell transcriptomic, proteomic, functional profiling of primary to compare immune responses from unvaccinated vaccinated during SARS-CoV-2 Delta wave....
Abstract Background The determinants of coronavirus disease 2019 (COVID-19) severity and extrapulmonary complications (EPCs) are poorly understood. We characterized relationships between severe acute respiratory syndrome 2 (SARS-CoV-2) RNAemia severity, clinical deterioration, specific EPCs. Methods used quantitative digital polymerase chain reaction (qPCR dPCR) to quantify SARS-CoV-2 RNA from plasma in 191 patients presenting the emergency department with COVID-19. recorded patient...
Natural killer (NK) cells likely play an important role in immunity to malaria, but the effect of repeated malaria on NK cell responses remains unclear. Here, we comprehensively profiled response a cohort 264 Ugandan children. Repeated exposure was associated with expansion atypical, CD56 neg population that differed transcriptionally, epigenetically, and phenotypically from dim cells, including decreased expression PLZF Fc receptor γ-chain, increased histone methylation, protein LAG-3, KIR,...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific CD4+ T cells are likely important in immunity against 2019 (COVID-19), but our understanding of longitudinal dynamics following infection and specific features that correlate with the maintenance neutralizing antibodies remains limited. Here, we characterize SARS-CoV-2-specific a cohort 109 COVID-19 outpatients enrolled during infection. The quality response shifts from producing interferon gamma (IFNγ) to tumor necrosis...
The recent decline in global malaria burden has stimulated efforts toward Plasmodium falciparum elimination. Understanding the biology of transmission stages may provide opportunities to reduce or prevent onward mosquitoes. Immature P. stages, termed I IV gametocytes, sequester human bone marrow before release into circulation as mature stage V gametocytes. This process likely involves interactions between host receptors and potentially immunogenic adhesins on infected red blood cell (iRBC)...
Despite recent efforts toward control and elimination, malaria remains a major public health problem worldwide. Plasmodium falciparum resistance against artemisinin, used in front line combination drugs, is on the rise, only approved vaccine shows limited efficacy. Combinations of novel tailored drug interventions are required to maintain momentum current elimination program. Current evidence suggests that strain-transcendent protection infection can be achieved using whole organism...
Background: The great majority of severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) infections are mild and uncomplicated, but some individuals with initially COVID-19 progressively develop more symptoms. Furthermore, there is substantial heterogeneity in SARS-CoV-2-specific memory immune responses following infection. There remains a critical need to identify host biomarkers predictive clinical immunological outcomes SARS-CoV-2-infected patients. Methods: Leveraging...
The regulation of inflammation is a critical aspect disease tolerance and naturally acquired clinical immunity to malaria. Here, we demonstrate using RNA sequencing epigenetic landscape profiling by cytometry time-of-flight, that the inflammatory pathways during asymptomatic parasitemia occurs downstream pathogen sensing-at level. abundance certain markers (methylation H3K27 dimethylation arginine residues) decreased prevalence histone variant H3.3 correlated with suppressed cytokine...
Clinicians in the emergency department (ED) face challenges concurrently assessing patients with suspected COVID-19 infection, detecting bacterial coinfection, and determining illness severity since current practices require separate workflows. Here, we explore accuracy of IMX-BVN-3/IMX-SEV-3 29 mRNA host response classifiers simultaneously severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection coinfections predicting clinical COVID-19. A total 161 PCR-confirmed (52.2%...
The great majority of SARS-CoV-2 infections are mild and uncomplicated, but some individuals with initially COVID-19 progressively develop more severe symptoms. Furthermore, there is substantial heterogeneity in SARS-CoV-2-specific memory immune responses following infection. There remains a critical need to identify host biomarkers predictive clinical immunologic outcomes SARS-CoV-2-infected patients. Leveraging longitudinal samples data from trial infected outpatients, we used proteomics...
Individuals infected with P. falciparum develop antibody responses to intra-erythrocytic gametocyte proteins and exported present on the surface of erythrocytes. However, there is currently limited knowledge immunogenicity antigens specificity gametocyte-induced responses. In this study, we assessed in participants two controlled human malaria infection (CHMI) studies by ELISA, multiplexed bead-based assays protein microarray. By comparing without exposure, aimed disentangle response induced...
Abstract Objectives Natural killer (NK) cells make important contributions to anti‐malarial immunity through antibody‐dependent cellular cytotoxicity (ADCC), but the role of different components this pathway in promoting NK cell activation remains unclear. Methods We compared functions and phenotypes from malaria‐exposed malaria‐naive donors, then varied erythrocyte genetic background, Plasmodium falciparum strain opsonising plasma used ADCC observe their impacts on degranulation as measured...
Abstract The great majority of SARS-CoV-2 infections are mild and uncomplicated, but some individuals with initially COVID-19 progressively develop more severe symptoms. Furthermore, to moderate an important contributor ongoing transmission. There remains a critical need identify host immune biomarkers predictive clinical virologic outcomes in SARS-CoV-2-infected patients. Leveraging longitudinal samples data from trial Peginterferon Lambda for treatment infected outpatients, we used...
Abstract Natural Killer (NK) cells likely play an important role in immunity to malaria, but whether repeated malaria modifies the NK cell response remains unclear. Here, we comprehensively profiled a cohort of 264 Ugandan children. Repeated exposure was associated with expansion atypical, CD56neg population that differed transcriptionally, epigenetically, and phenotypically from CD56dim cells, including decreased expression PLZF Fc receptor g chain, increased histone methylation, protein...
The regulation of inflammation is a critical aspect disease tolerance and naturally acquired immunity to malaria. Here, we demonstrate using RNA sequencing epigenetic landscape profiling by cytometry Time-Of-Flight (EpiTOF), that the inflammatory pathways during asymptomatic parasitemia occurs downstream pathogen sensing—at level. abundance certain markers (methylation H3K27 dimethylation arginine residues) decreased prevalence histone variant H3.3 correlated with suppressed cytokine...
Background: Malaria in pregnancy causes higher morbidity primigravid women compared to multigravid; however, the correlates and mechanisms underlying this gravidity-dependent protection against remain incompletely understood.Methods: We characterized cellular immune response during second trimester of pregnant (n=203) living eastern Uganda, a highly malaria-endemic region, combining RNA sequencing, multiparameter flow cytometry, functional assays. responses between multigravid assessed...