A5101551974- Antimicrobial Peptides and Activities
- Protein Hydrolysis and Bioactive Peptides
- Proteins in Food Systems
- Probiotics and Fermented Foods
- Bacterial Identification and Susceptibility Testing
- Reproductive tract infections research
- Polysaccharides Composition and Applications
- Bacterial Infections and Vaccines
- Antimicrobial agents and applications
- Freezing and Crystallization Processes
- Phytase and its Applications
- Streptococcal Infections and Treatments
- Food Science and Nutritional Studies
- Antibiotic Resistance in Bacteria
- Antimicrobial Resistance in Staphylococcus
- Food composition and properties
- Food Chemistry and Fat Analysis
- Agricultural pest management studies
- Adsorption, diffusion, and thermodynamic properties of materials
- Hydrological Forecasting Using AI
- Amoebic Infections and Treatments
- Tannin, Tannase and Anticancer Activities
- Legionella and Acanthamoeba research
- Surface Chemistry and Catalysis
- Metamaterials and Metasurfaces Applications
Stanford University
2020-2022
Brigham Young University
2017-2019
Shiraz University
2013-2014
Academic Center for Education, Culture and Research
2011
University of California, Los Angeles
2010
Use of chlorhexidine in clinical settings has led to concerns that repeated exposure bacteria sub-lethal doses might result resistance and cross with other cationic antimicrobials including colistin, endogenous antimicrobial peptides (AMPs) their mimics, ceragenins. We have previously shown colistin-resistant Gram-negative remain susceptible AMPs Here, we investigated the potential for between chlorhexidine, ceragenins by serial standard strains generate resistant populations organisms....
The susceptibility of colistin-resistant clinical isolates Klebsiella pneumoniae to ceragenins and antimicrobial peptides (AMPs) suggests that there is little no cross-resistance between colistin ceragenins/AMPs lipid A modifications are found in bacteria with modest changes high levels resistance colistin. These results suggest differences the mechanisms ceragenins/AMPs.
Endotracheal tubes provide an abiotic surface on which bacteria and fungi form biofilms, the release of endotoxins planktonic organisms can cause damaging inflammation infections. Ceragenins are small molecule mimics antimicrobial peptides with broad-spectrum antibacterial antifungal activity, a ceragenin may be used to protection endotracheal tube. A hydrogel film, containing CSA-131, was generated tubes. Elution CSA-131 quantified in drip-flow static systems, activity measured repeated...
Candida auris has emerged as a serious threat to human health. Of particular concern are the resistance profiles of many clinical isolates, with some being resistant multiple classes antifungals.Measure susceptibilities C. in planktonic and biofilm forms, ceragenins (CSAs). Determine effectiveness selected gel cream formulations eradicating fungal infections tissue explants.A collection 100 isolates available at CDC was screened for susceptibility lead ceragenin. A smaller used characterize...
Ceragenins are small molecule mimics of endogenous antimicrobial peptides (AMPs), and as such display broadspectrum activity. These molecules derived from a common bile acid can be prepared at large scale. Because ceragenins not peptide based, they substrates for proteases. Gram-negative positive bacteria susceptible to ceragenins, including drug resistant organisms. Although colistin have features, retain full antibacterial activity against colistin-resistant bacteria. Bactericidal involves...
Ceragenins were designed as non-peptide mimics of endogenous antimicrobial peptides, and they display broad-spectrum antibacterial antifungal activities, including the ability to eradicate established biofilms. These features ceragenins make them attractive potential therapeutics for persistent infections in lung, those associated with cystic fibrosis. A characteristic an optimal therapeutic use lungs trachea is exertion potent activities without damaging cilia that play a critical role...
1. Aminlari L., Hashemi M.M., Aminlari, M., Modified lysozymes as novel broad spectrum natural antimicrobial agents in foods. J. Food Sci., 2014, 79, R1077-1090. Google Scholar
Clinicians in the emergency department (ED) face challenges concurrently assessing patients with suspected COVID-19 infection, detecting bacterial coinfection, and determining illness severity since current practices require separate workflows. Here, we explore accuracy of IMX-BVN-3/IMX-SEV-3 29 mRNA host response classifiers simultaneously severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection coinfections predicting clinical COVID-19. A total 161 PCR-confirmed (52.2%...
The continuous emergence of multidrug resistant pathogens is a major global health concern. Although antimicrobial peptides (AMPs) have shown promise as possible means combatting strains without readily engendering resistance, costs production and targeting by proteases limit their utility. Ceragenins are non-peptide AMP mimics that overcome these shortcomings while retaining broad-spectrum activity. To further characterize the antibacterial activities ceragenins, against collection...
Traditional antimicrobial susceptibility testing (AST) is growth dependent and time-consuming. With rising rates of drug-resistant infections, a novel diagnostic method critically needed that can rapidly reveal pathogen's to guide appropriate treatment. Recently, RNA sequencing has been identified as powerful tool explore transcriptional gene expression improve AST.RNA was used investigate the potential markers for rapid molecular AST using Klebsiella pneumoniae ciprofloxacin model....
Consumers' awareness about the nutritional profile of their diets has made industry to respond needs seriously. In this study, response surface methodology was used analyze effect three fat replacers and two sweeteners on sensory attributes viscosity low- calorie pistachio butter. Balangu seed extract (BSG) (0.01-0.04), Reihan gum (RSG) (0.01-0.023), xanthan (0.06-0.1), isomalt (0-1) sucrose (0.25-1) were levels investigated. A central composite design develop models for responses. The...
The rise of antimicrobial-resistant pathogens can be attributed to the lack a rapid pathogen identification (ID) or antimicrobial susceptibility testing (AST), resulting in delayed therapeutic decisions at point care. Gonorrhea is usually empirically treated, with no AST results available before treatment, thus contributing drug resistance. Here, we present platform using RNA signatures for Neisseria gonorrhoeae . Transcriptome sequencing (RNA-seq) followed by bioinformatic tools was applied...