A5041257579- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Nail Diseases and Treatments
- Plant Pathogens and Fungal Diseases
- Pneumocystis jirovecii pneumonia detection and treatment
- Antimicrobial Resistance in Staphylococcus
- Infectious Diseases and Mycology
- Bacterial Identification and Susceptibility Testing
- Probiotics and Fermented Foods
- Antibiotic Use and Resistance
- Yeasts and Rust Fungi Studies
- Fungal and yeast genetics research
- Respiratory and Cough-Related Research
- Mycotoxins in Agriculture and Food
- Neutropenia and Cancer Infections
- Antibiotic Resistance in Bacteria
- Synthesis and Biological Evaluation
- Infective Endocarditis Diagnosis and Management
- Cystic Fibrosis Research Advances
- Parasitic Infections and Diagnostics
- Plant-Microbe Interactions and Immunity
- Mycobacterium research and diagnosis
- Mycorrhizal Fungi and Plant Interactions
- Peptidase Inhibition and Analysis
- Antibiotics Pharmacokinetics and Efficacy
Centers for Disease Control and Prevention
2016-2025
Radboud University Nijmegen
2014-2024
Radboud University Medical Center
2014-2024
European Hematology Association
2024
Temple University Hospital
2024
National Center for Emerging and Zoonotic Infectious Diseases
2013-2023
United States Department of Health and Human Services
2020-2023
Waterborne Environmental (United States)
2012-2023
Philadelphia Department of Public Health
2022
Hospital of the University of Pennsylvania
2022
Invasive fungal diseases (IFDs) remain important causes of morbidity and mortality. The consensus definitions the Infectious Diseases Group European Organization for Research Treatment Cancer Mycoses Study have been immense value to researchers who conduct clinical trials antifungals, assess diagnostic tests, undertake epidemiologic studies. However, their utility has not extended beyond patients with cancer or recipients stem cell solid organ transplants. With newer techniques available, it...
Candida auris, a multidrug-resistant yeast that causes invasive infections, was first described in 2009 Japan and has since been reported from several countries. To understand the global emergence epidemiology of C. we obtained isolates 54 patients with auris infection Pakistan, India, South Africa, Venezuela during 2012–2015 type specimen Japan. Patient information available for 41 isolates. We conducted antifungal susceptibility testing whole-genome sequencing (WGS). Available clinical...
During the 12-year period from 1993 to 2004, antimicrobial susceptibility profiles of 74,394 gram-negative bacillus isolates recovered intensive care unit (ICU) patients in United States hospitals were determined by participating and collected a central location. MICs for 12 different agents using standardized broth microdilution method. The 11 organisms most frequently isolated Pseudomonas aeruginosa (22.2%), Escherichia coli (18.8%), Klebsiella pneumoniae (14.2%), Enterobacter cloacae...
ABSTRACT The echinocandin class of antifungal agents is considered to be the first-line treatment bloodstream infections (BSI) due Candida glabrata . Recent reports BSI strains C. resistant both fluconazole and echinocandins are concern prompted us review experience two large surveillance programs, SENTRY Antimicrobial Surveillance Program for years 2006 through 2010 Centers Disease Control Prevention population-based conducted in 2008 2010. vitro susceptibilities 1,669 isolates fluconazole,...
Candidemia is common and associated with high morbidity mortality; changes in population-based incidence rates have not been reported.We conducted active, surveillance metropolitan Atlanta, Georgia, Baltimore City/County, Maryland (combined population 5.2 million), during 2008-2011. We calculated candidemia antifungal drug resistance compared prior (Atlanta, 1992-1993; Baltimore, 1998-2000).We identified 2675 cases of 2329 isolates 3 years surveillance. Mean annual crude per 100 000...
Mucormycosis is a fungal infection caused by environmentally acquired molds. We investigated cluster of cases cutaneous mucormycosis among persons injured during the May 22, 2011, tornado in Joplin, Missouri.We defined case as soft-tissue person tornado, with evidence mucormycete on culture or immunohistochemical testing plus DNA sequencing. conducted case-control study reviewing medical records and conducting interviews patients hospitalized controls. sequencing whole-genome were performed...
In less than a decade, C. auris has emerged in health care settings worldwide; this species is capable of colonizing skin and causing outbreaks invasive candidiasis. contrast to other Candida species, unique its ability spread via nosocomial transmission high rates drug resistance. As part the public response, whole-genome sequencing played major role characterizing dynamics detecting new introductions. Through global collaboration, we assessed genome evolution isolates from 19 countries....
Candida auris, an emerging fungus that can cause invasive infections, is associated with high mortality and often resistant to multiple antifungal drugs. C. auris was first described in 2009 after being isolated from external ear canal discharge of a patient Japan (1). Since then, reports including bloodstream have been published several countries, Colombia, India, Israel, Kenya, Kuwait, Pakistan, South Africa, Korea, Venezuela, the United Kingdom (2-7). To determine whether present States...
Recent reports have demonstrated a decline in bacterial bloodstream infections (BSIs) following adherence to central line insertion practices; however, declines been less evident for BSIs due Candida species.We conducted active, population-based laboratory surveillance candidemia metropolitan Atlanta, GA and Baltimore, MD over 5-year period. We calculated annual incidence antifungal drug resistance rates.We identified 3,848 cases from 2008-2013. Compared with 2008, per 100,000 person-years...
Between 2008 and 2011, population-based candidemia surveillance was conducted in Atlanta, GA, Baltimore, MD. Surveillance had been previously performed Atlanta 1992 to 1993 Baltimore 1998 2000, making this the first over multiple time points United States. From 2,675 identified cases of current surveillance, 2,329 Candida isolates were collected. albicans no longer comprised majority but remained most frequently isolated species (38%), followed by glabrata (29%), parapsilosis (17%),...
Abstract The fungal pathogen Candida glabrata has emerged as a major health threat since it readily acquires resistance to multiple drug classes, including triazoles and/or echinocandins. Thus far, cellular mechanisms promoting the emergence of classes have not been described in this organism. Here we demonstrate that mutator phenotype caused by mismatch repair defect is prevalent C. clinical isolates. Strains carrying alterations gene MSH2 exhibit higher propensity breakthrough antifungal...
Epidemiological cutoff values (ECVs) for the Cryptococcus neoformans-Cryptococcus gattii species complex versus fluconazole, itraconazole, posaconazole, and voriconazole are not available. We established ECVs these agents based on wild-type (WT) MIC distributions. A total of 2,985 to 5,733 CLSI MICs C. neoformans (including isolates molecular type VNI [MICs 759 1,137 isolates] VNII, VNIII, VNIV 24 57 isolates]) 705 975 42 260 VGI, VGII, VGIII, VGIV isolates) were gathered in 15 laboratories...
We surveyed 497 isolates of Aspergillus fumigatus collected from 2008 to 2009 as part the ARTEMIS global surveillance study for elevated MIC values itraconazole, voriconazole, and posaconazole. Sequencing cyp51A gene revealed that 8/29 with one or more triazoles, all originating in China, contained TR/L98H mutation associated resistant European A. fumigatus. This is first time has been identified outside Europe.
ABSTRACT Candida glabrata is the second leading cause of candidemia in U.S. hospitals. Current guidelines suggest that an echinocandin be used as primary therapy for treatment C. disease due to high rate resistance fluconazole. Recent case reports indicate echinocandins may increasing. We performed susceptibility testing on 1,380 isolates collected between 2008 and 2013 from four cities, Atlanta, Baltimore, Knoxville, Portland. Our analysis showed 3.1%, 3.3%, 3.6% were resistant...
Although Clinical and Laboratory Standards Institute (CLSI) clinical breakpoints (CBPs) are available for interpreting echinocandin MICs Candida spp., epidemiologic cutoff values (ECVs) based on collective MIC data from multiple laboratories have not been defined. While collating CLSI caspofungin 145 to 11,550 isolates 17 (Brazil, Canada, Europe, Mexico, Peru, the United States), we observed an extraordinary amount of modal variability (wide ranges) among as well truncated bimodal...
Abstract Background Candida auris is a multidrug-resistant yeast associated with hospital outbreaks worldwide. During 2015–2016, multiple were reported in Colombia. We aimed to understand the extent of contamination healthcare settings and characterize molecular epidemiology C. Methods sampled patients, patient contacts, workers, environment 4 hospitals recent outbreaks. Using standardized protocols, people swabbed at different body sites. Patient procedure rooms sectioned into zones...
ABSTRACT Candida auris is an emerging multidrug-resistant fungal pathogen causing nosocomial and invasive infections associated with high mortality. C. commonly misidentified as several different yeast species by commercially available phenotypic identification platforms. Thus, there urgent need for a reliable diagnostic method. In this paper, we present fast, robust, easy-to-perform interpret PCR real-time assays to identify related species: duobushaemulonii , haemulonii lusitaniae ....
Candidemia is a bloodstream infection (BSI) caused by yeasts in the genus Candida. one of most common health care-associated BSIs United States, with all-cause in-hospital mortality up to 30%.2012-2016.CDC's Emerging Infections Program (EIP), collaboration among CDC, state departments, and academic partners that was established 1995, used conduct active, population-based laboratory surveillance for candidemia 22 counties four states (Georgia, Maryland, Oregon, Tennessee) combined population...