A5070460063- Fungal Infections and Studies
- Antifungal resistance and susceptibility
- Plant Pathogens and Fungal Diseases
- Pneumocystis jirovecii pneumonia detection and treatment
- Nail Diseases and Treatments
- Infectious Diseases and Mycology
- Pneumonia and Respiratory Infections
- Actinomycetales infections and treatment
- HIV/AIDS oral health manifestations
- Tuberculosis Research and Epidemiology
- T-cell and Retrovirus Studies
- Respiratory and Cough-Related Research
- Mycorrhizal Fungi and Plant Interactions
- Injury Epidemiology and Prevention
- Animal and Plant Science Education
- Toxin Mechanisms and Immunotoxins
- Eosinophilic Disorders and Syndromes
- Mycotoxins in Agriculture and Food
- Infections and bacterial resistance
- Education in Rural Contexts
- Antibiotic Use and Resistance
- Cutaneous lymphoproliferative disorders research
- Insect Utilization and Effects
- Cytomegalovirus and herpesvirus research
- Neonatal Respiratory Health Research
Universidad Peruana Cayetano Heredia
2013-2024
Hospital Nacional Cayetano Heredia
2011-2022
Instituto de Medicina Tropical
2004-2022
Alexander von Humboldt Biological Resources Research Institute
2016
EsSALUD
2008
GTx (United States)
2001
Abstract Guidelines for the management of patients with sporotrichosis were prepared by an Expert Panel Infectious Diseases Society America and replace guidelines published in 2000. The are intended use internists, pediatricians, family practitioners, dermatologists. They include evidence-based recommendations lymphocutaneous, cutaneous, pulmonary, osteoarticular, meningeal, disseminated sporotrichosis. Recommendations also provided treatment pregnant women children.
Although Clinical and Laboratory Standards Institute (CLSI) clinical breakpoints (CBPs) are available for interpreting echinocandin MICs Candida spp., epidemiologic cutoff values (ECVs) based on collective MIC data from multiple laboratories have not been defined. While collating CLSI caspofungin 145 to 11,550 isolates 17 (Brazil, Canada, Europe, Mexico, Peru, the United States), we observed an extraordinary amount of modal variability (wide ranges) among as well truncated bimodal...
Objectives: A multinational, multicentre, open-label clinical trial was conducted to evaluate the safety and efficacy of posaconazole, an extended-spectrum triazole antifungal agent, in subjects with invasive fungal infections who had refractory disease or were intolerant standard therapy. In this subanalysis, we report on those a infection that involved CNS.
We conducted a phase 2, double-blind, placebo-controlled study to evaluate the safety and antifungal activity of adjuvant recombinant interferon (rlFN)-γ1b in patients with acquired immunodeficiency syndrome acute cryptococcal meningitis. Patients received 100 or 200μg rIFN-γ1b placebo, thrice weekly for 10 weeks, plus standard therapy intravenous amphotericin B, without flucytosine, followed by fluconazole. End points included conversion cerebrospinal fluid fungal cultures from positive...
Although epidemiological cutoff values (ECVs) have been established for Candida spp. and the triazoles, they are based on MIC data from a single laboratory. We ECVs eight species fluconazole, posaconazole, voriconazole wild-type (WT) distributions isolates of C. albicans (n=11,241 isolates), glabrata (7,538), parapsilosis (6,023), tropicalis (3,748), krusei (1,073), lusitaniae (574), guilliermondii (373), dubliniensis (162). The 24-h CLSI broth microdilution MICs were collated multiple...
Sporotrichosis is a sporadic and rare mycotic infection in most of the developed world. In many parts developing world, sporotrichosis much more commonly recognized, but epidemiological data are generally lacking from these regions. We report epidemiological, clinical, treatment 238 cases culture-proven occurring relatively remote area south central highlands Peru that were retrospectively collected during 1995–1997. Most (60%) occurred children aged ≤14 years, affected anatomic site was...
Eumycetoma and chromoblastomycosis are chronic, disfiguring fungal infections of the subcutaneous tissue that rarely resolve spontaneously. Most patients do not achieve sustained long-term benefits from available treatments; therefore, new therapeutic options needed. We evaluated efficacy posaconazole, a extended-spectrum triazole antifungal agent, in 12 with eumycetoma or refractory to existing therapies. Posaconazole 800 mg/d was given divided doses for maximum 34 months. Complete partial...
The diagnosis of fungal Neglected Tropical Diseases (NTD) is primarily based on initial visual recognition a suspected case followed by confirmatory laboratory testing, which often limited to specialized facilities. Although molecular and serodiagnostic tools have advanced, substantial gap remains between the desirable practical in endemic settings. To explore this issue further, we conducted survey subject matter experts optimal diagnostic methods sufficient initiate treatment well-equipped...
From March 1999 to 2000, we conducted a prospective multicenter study of candidemia involving five tertiary care hospitals from four countries in Latin America. Yeast isolates were identified by classical methods and the antifungal susceptibility profile was determined according National Committee for Clinical Laboratory Standards microbroth assay method. During 12 month-period able collect total 103 bloodstream Candida spp. C. albicans most frequently isolated species accounting 42% all...
Background The incidence of candidemia is increasing in developing countries. Very little known about the epidemiology Peru. aim this study to describe incidence, microbiology, clinical presentation and outcomes Candida bloodstream infections three Lima-Callao hospitals. Methods spp. isolates were identified prospectively at participant hospitals between November 2013 January 2015. Susceptibility testing for amphotericin B, fluconazole, posaconazole, voriconazole anidulafungin was performed...
ABSTRACT Since epidemiological cutoff values (ECVs) using CLSI MICs from multiple laboratories are not available for Candida spp. and the echinocandins, we established ECVs anidulafungin micafungin on basis of wild-type (WT) MIC distributions (for organisms in a species-drug combination with no detectable acquired resistance mechanisms) 8,210 albicans , 3,102 C. glabrata 3,976 parapsilosis 2,042 tropicalis 617 krusei 258 lusitaniae 234 guilliermondii 131 dubliniensis isolates. broth...
Although contact with domestic cats has been shown to be a risk factor for sporotrichosis in endemic areas, systematic evaluation of apparently unaffected as possible reservoirs infection not explored. The goals this study were identify the following aspects area Abancay, Peru: (i) overall prevalence cat population, (ii) most common site where fungus can isolated from these cats, and (iii) whether without identifiable skin lesions may carriers oral mucosa, nasal or nails. One household each...
Estimating epidemiological cutoff endpoints (ECVs/ECOFFS) may be hindered by the overlap of MICs for mutant and nonmutant strains (strains harboring or not mutations, respectively). Posaconazole MIC distributions Aspergillus fumigatus species complex were collected from 26 laboratories (in Australia, Canada, Europe, India, South North America, Taiwan) published studies. Distributions that fulfilled CLSI criteria pooled ECVs estimated. The sensitivity three ECV analytical techniques (the...
Triazole-resistance has been reported increasingly in Aspergillus fumigatus. An international expert team proposed to avoid triazole monotherapy for the initial treatment of invasive aspergillosis regions with >10% environmental-resistance, but this prevalence is largely unknown most American and African countries. Here, we screened 584 environmental samples (soil) from urban rural locations Mexico, Paraguay, Peru Latin America Benin Nigeria Africa triazole-resistant A. Samples were using...
ABSTRACT Amplified fragment length polymorphism (AFLP) was used to analyze the genetic diversity of Peruvian strains Sporothrix schenckii and compare them a panel non-Peruvian strains. AFLP analysis suggests that can be divided into two homogeneous clusters with no reference geographical origin or clinical form sporotrichosis. The from abroad present heterogeneous profiles, Bolivian strain Colombian related one population. Sequencing internal transcribed spacer 2, examine relationships over...
Lobomycosis is a chronic subcutaneous mycosis for which no standard treatment available to date. We describe patient in Peru with lobomycosis on the left earlobe that was successfully treated posaconazole 27 months. No evidence of recurrence observed after five years follow-up.
Yeast identification and in vitro susceptibility testing provide helpful information for appropriate administration of antifungal treatments; however, few reports from the Latin American region have been published. The aim this study was to identify species present isolates bloodstream infections diagnosed nine hospitals Lima, Peru determine their four drugs. We tested identified 153 collected between October 2009 August 2011 using standard methods. PCR PCR-RFLP assays were performed...
Data on features of Pneumocystis primary infection in infancy are still fragmented. To study infection, 192 infants who were monitored for acute pulmonary disease or fever over a 40-month period retrospectively investigated. P. jirovecii detection archival nasopharyngeal aspirates was performed using qPCR assay. Factors associated with assessed univariate and multivariate analyses. genotypes control group adults contemporaneously diagnosed pneumonia identified unilocus, bilocus, multilocus...
Background Recommended treatment for cutaneous sporotrichosis consists of a saturated solution potassium iodide (SSKI) administered in three daily doses (tid). Because compliance with this regimen has been problem our previous experience, we evaluated the use one (qd) full dose SSKI. Methods patients culture-confirmed were entered randomized, nonblinded study to compare safety and efficacy qd vs. tid dosage Results Fifty-seven enrolled receive either (29) or (28) Three (1 2 group) not...
Azole resistance among Aspergillus fumigatus isolates, which is mainly related to mutations in the cyp51A gene, a concern because it rising, worldwide disseminated, and associated with treatment failure death. Data on azole of aspergillus from Latin American countries very scarce do not exist for Peru. Two hundred seven clinical isolates collected prospectively underwent mycology molecular testing specie identification, 143 were confirmed as A. sensu stricto (AFSS). All AFSS tested vitro...