A5103093576- Antimicrobial Resistance in Staphylococcus
- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Bacterial biofilms and quorum sensing
- Pneumocystis jirovecii pneumonia detection and treatment
- Bacterial Identification and Susceptibility Testing
- Pneumonia and Respiratory Infections
- Gallbladder and Bile Duct Disorders
- Pediatric Hepatobiliary Diseases and Treatments
- Drug Transport and Resistance Mechanisms
- Mycotoxins in Agriculture and Food
- Nail Diseases and Treatments
- Fungal Biology and Applications
- Entomopathogenic Microorganisms in Pest Control
- Biochemical and Structural Characterization
- Respiratory viral infections research
KU Leuven
1989-2024
Rega Institute for Medical Research
1989-2004
Abstract. Lagrou K, Van Eldere J, Keuleers S, Hagen F, Merckx R, Verhaegen Peetermans WE, Boekhout T (University Hospital Leuven, Belgium; and Centraalbureau voor Schimmelcultures, CT Utrecht, the Netherlands) Zoonotic transmission of Cryptococcus neoformans from a magpie to an immunocompetent patient (Case report). J Intern Med 2005; 257: 385–388. We report case cryptococcal meningitis in female with exposure pet ( Pica pica ). Genetically indistinguishable isolates were cultured...
Triazole-resistance has been reported increasingly in Aspergillus fumigatus. An international expert team proposed to avoid triazole monotherapy for the initial treatment of invasive aspergillosis regions with >10% environmental-resistance, but this prevalence is largely unknown most American and African countries. Here, we screened 584 environmental samples (soil) from urban rural locations Mexico, Paraguay, Peru Latin America Benin Nigeria Africa triazole-resistant A. Samples were using...
Recently, mutations in the 3-hydroxy-3-methylglutaryl-coenzyme-A-reductase-encoding gene (hmg1), a involved ergosterol production, were associated with triazole-resistance Aspergillus fumigatus. In this study, we determined prevalence and characteristics of hmg1 collection clinical triazole-resistant A. fumigatus isolates collected during 2001-2019 from two international mycology reference centers: Belgian National Reference Center for Mycosis Expertise Mycology Radboudumc/CWZ. Clinical...
Prevalence reports of triazole-resistance in Aspergillus fumigatus differ between countries and centers may likewise vary over time. Continuous local surveillance programs to establish the evolving epidemiology A. are crucial guide therapeutic recommendations. Here, we determined prevalence complex culture-positive patients at tertiary care center University Hospitals Leuven Belgium clinical isolates from 2016 2020.All cultured UZ 2020 were screened for triazole-resistance. Confirmation...
We isolated two strains of an unnamed Fusobacterium species from human intestinal microflora, which stereospecifically transformed bile acid 3-sulfates into C-3-unsubstituted, ring A-unsaturated acids. Both 3 alpha- and beta-sulfates 5 beta-bile acids were metabolized to delta 3-5 beta-cholenoic acids; alpha-bile converted a mixture 2-5 alpha-hydroxy-5 acids, whereas alpha-sulfates left intact. Unsulfated not unsaturated derivatives. These differ previously bacteria, desulfated sulfates...
Increasing resistance to triazole antifungals in Aspergillus fumigatus is worrisome because of the associated high mortality triazole-resistant A. (TRAF) infections. While most studies have focused on single triazole-susceptible (WT) or TRAF infections, reports cases developing mixed WT and infections been described several studies. However, prevalence their responses current recommended therapies are unknown could be inappropriate, leading poor clinical outcomes. To address urgent need for...
Triazole-resistant Aspergillus fumigatus (TRAF) isolates are a growing public health problem with worldwide distribution. Epidemiological data on TRAF is limited in Africa, particularly West Africa.