A5011701464- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Plant Pathogens and Fungal Diseases
- Peptidase Inhibition and Analysis
- Vector-borne infectious diseases
- Infectious Diseases and Mycology
- Nail Diseases and Treatments
- Viral Infections and Vectors
- Bacterial Identification and Susceptibility Testing
- Protein Degradation and Inhibitors
- Multiple Myeloma Research and Treatments
- Nosocomial Infections in ICU
- Pneumonia and Respiratory Infections
- Antibiotic Resistance in Bacteria
- Legionella and Acanthamoeba research
- Tuberculosis Research and Epidemiology
- Fungal and yeast genetics research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Antibiotic Use and Resistance
- Yersinia bacterium, plague, ectoparasites research
- Cystic Fibrosis Research Advances
- Actinomycetales infections and treatment
- Parasites and Host Interactions
- Ocular Infections and Treatments
Université Grenoble Alpes
2016-2025
Centre National de la Recherche Scientifique
2015-2025
Institut polytechnique de Grenoble
2018-2025
Centre Hospitalier Universitaire de Grenoble
2016-2025
VetAgro Sup
2022-2025
Translational Innovation in Medicine and Complexity
2014-2024
Laboratoire Rhéologie et Procédés
2015-2024
Centre Hospitalier Saint-Joseph Saint-Luc
2019
University of Antananarivo
2019
Université Joseph Fourier
2010-2017
Lyme borreliosis, caused by the tick-borne bacterium Borrelia burgdorferi, has become most common vector-borne disease in North America over last three decades. To understand dynamics of epizootic spread and to predict evolutionary trajectories B. accurate information on population structure relationships pathogen is crucial. We, therefore, developed a multilocus sequence typing (MLST) scheme for burgdorferi based eight chromosomal housekeeping genes. We validated MLST specimens from Europe,...
ABSTRACT Analysis of Lyme borreliosis (LB) spirochetes, using a novel multilocus sequence analysis scheme, revealed that OspA serotype 4 strains (a rodent-associated ecotype) Borrelia garinii were sufficiently genetically distinct from bird-associated B. to deserve species status. We suggest be raised status and named bavariensis sp. nov. The rooted phylogenetic trees provide insights into the evolutionary history LB spirochetes.
ABSTRACT Fingerprinting of more than 700 clinical and environmental isolates Aspergillus fumigatus from four differential hospital settings was undertaken with a dispersed repeated DNA sequence. The analysis the showed that airborne A. population is extremely diverse, 85% strains being represented as single genotype isolated once. remaining 15% were several times able to persist for months in same environment. No found be associated specific location inside hospital, identical different...
The outcomes for 73 invasive fusariosis patients treated with voriconazole were investigated. Patients proven (n = 67) or probable 6) infections identified from the clinical database 39) and French National Reference Center Mycoses Antifungals 34). Investigator-determined success was a complete partial response. Survival determined day 1 of therapy to last known alive. 2 79 years old (median, 43 years), 66% male. Identified Fusarium species (62%) F. solani, moniliforme, proliferatum,...
<h3>Importance</h3> Although frequently used in treating intensive care unit (ICU) patients with sepsis, empirical antifungal therapy, initiated for suspected fungal infection, has not been shown to improve outcome. <h3>Objective</h3> To determine whether micafungin reduces invasive infection (IFI)–free survival at day 28. <h3>Design, Setting, and Participants</h3> Multicenter double-blind placebo-controlled study of 260 nonneutropenic, nontransplanted, critically ill ICU-acquired...
Chronic pulmonary aspergillosis (CPA) is a recognized complication of tuberculosis (TB). In 2015, the World Health Organization reported 2.2 million new cases nonbacteriologically confirmed TB; some these patients probably had undiagnosed CPA. October 2016, Global Action Fund for Fungal Infections convened an international expert panel to develop case definition CPA resource-constrained settings. This defined as illness >3 months and all following: 1) weight loss, persistent cough, and/or...
To evaluate efficacy of laminar airflow facilities plus high-efficiency particulate air (HEPA) filtration and HEPA alone in preventing environmental Aspergillus contamination during hospital renovation. show the usefulness surveillance to facilitate protection patients at risk for invasive pulmonary aspergillosis.Prospective sampling surfaces conidia 2-year period.A hematological department adjacent building renovation a university hospital.1,047 samples 1,178 surface were collected from...
Current laboratory and radiological methods for diagnosis of invasive aspergillosis (IA) lack sensitivity specificity.We prospectively evaluated the diagnostic value twice-weekly screening circulating Aspergillus fumigatus A. flavus DNA with a polymerase chain reaction-enzyme-linked immunosorbent assay (PCR-ELISA).Among 201 adult patients hematological malignancies who were included in study, 55 IA cases diagnosed. On basis analysis 1205 serum samples from 167 patients, sensitivity,...
The diagnosis of fungal Neglected Tropical Diseases (NTD) is primarily based on initial visual recognition a suspected case followed by confirmatory laboratory testing, which often limited to specialized facilities. Although molecular and serodiagnostic tools have advanced, substantial gap remains between the desirable practical in endemic settings. To explore this issue further, we conducted survey subject matter experts optimal diagnostic methods sufficient initiate treatment well-equipped...
The gut microbiota is now recognized as a key parameter affecting the host’s anti-cancer immunosurveillance and ability to respond immunotherapy. Therefore, optimal modulation for preventive therapeutic purposes very appealing. Diet one of most potent modulators microbiota, thus nutritional intervention could be exploited improve host immunity. Here, we show that an inulin-enriched diet, prebiotic known promote immunostimulatory bacteria, triggers enhanced Th1-polarized CD4 + CD8 αβ T...
Early evaluation of treatment efficacy in invasive aspergillosis (IA), a leading cause morbidity and mortality hematological patients, remains challenge. We conducted prospective study to evaluate the performance different markers predicting outcome patients with IA. Both clinical biological criteria were assessed 7, 14, 21, 45 days after inclusion study, was at day 60. The association between baseline data their evolution response analyzed. A total 57 (4 proven, 44 probable, 9 possible...
Antifungal prescription practices have changed over the last decade, and impact of these changes is unclear. Our objective here was to evaluate effect antifungal drug use on distribution susceptibility Candida spp. in a French intensive care unit (ICU).Antifungal measured as number defined daily doses per 1000 hospital days (DDDs/1000HD). The 6 year period (2004-09) MICs drugs 2007-09 were determined. Statistical analyses performed assess relationships between use, MIC time.Of 26,450 samples...
Systemic antifungal treatments are empirically administered to the sickest critically ill patients, often without documented invasive fungal infection.To estimate impact of systemic treatment on 30-day survival patients suspected have candidiasis.All nonneutropenic, nontransplant recipients managed in five intensive care units intubated for at least 5 days, and free candidiasis, were included. To account differences patients' characteristics recorded daily before study end point, a causal...
To identify the factors associated with interindividual pharmacokinetic (PK) variability of micafungin and to evaluate probability reaching previously determined PK/pharmacodynamic efficacy thresholds (AUC/MIC >5000 for non-parapsilosis Candida sp. ≥285 parapsilosis) recommended 100 mg daily dose in ICU patients sepsis mechanical ventilation. One hundred were included 436 concentrations available PK analysis performed NONMEM software. PTA was by Monte Carlo simulations. Micafungin obeyed a...
MDR Candida strains are emerging. Next-generation sequencing (NGS), which enables extensive and deep genome analysis, was used to investigate echinocandin azole resistance in clinical isolates. Six genes commonly involved antifungal (ERG11, ERG3, TAC1, CgPDR1, FKS1 FKS2) were analysed using NGS 40 isolates (18 albicans, 15 glabrata 7 parapsilosis). The strategy validated with known sequences. Then, 8 displaying 23 sequential collected from 10 patients receiving therapy analysed. A total of...