A5007856392- Probiotics and Fermented Foods
- Gut microbiota and health
- Microbial Metabolites in Food Biotechnology
- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Protein Hydrolysis and Bioactive Peptides
- Clostridium difficile and Clostridium perfringens research
- Meat and Animal Product Quality
- Infant Nutrition and Health
- Listeria monocytogenes in Food Safety
- Proteins in Food Systems
- Enzyme Production and Characterization
- Microbial Metabolic Engineering and Bioproduction
- Food composition and properties
- Diet and metabolism studies
- Iron Metabolism and Disorders
- Genomics and Phylogenetic Studies
- Gastrointestinal motility and disorders
- Infectious Diseases and Mycology
- Salmonella and Campylobacter epidemiology
- Nail Diseases and Treatments
- Biofuel production and bioconversion
- Microbial Inactivation Methods
- Milk Quality and Mastitis in Dairy Cows
- Plant Pathogens and Fungal Diseases
ETH Zurich
2016-2025
Department of Medical Sciences
2019-2024
Western University
2024
St. Joseph's Hospital
2024
Board of the Swiss Federal Institutes of Technology
2021-2022
Ministry of Agriculture, Fisheries and Food
2022
Food & Nutrition
2018
Vir Biotechnology (Switzerland)
2016-2017
Boston Children's Hospital
2015
Boston Children's Museum
2015
<h3>Background</h3> In-home iron fortification for infants in developing countries is recommended control of anaemia, but low absorption typically results >80% the passing into colon. Iron essential growth and virulence many pathogenic enterobacteria. We determined effect high dose in-home on infant gut microbiome intestinal inflammation. <h3>Methods</h3> performed two double-blind randomised controlled trials 6-month-old Kenyan (n=115) consuming home-fortified maize porridge daily 4...
Summary Breast milk has recently been recognized as source of commensal and potential probiotic bacteria. The present study investigated whether viable strains gut‐associated obligate anaerobes are shared between the maternal neonatal gut ecosystem via breastfeeding. Maternal faeces, breast corresponding faeces collected from seven mothers‐neonate pairs at three sampling points were analyzed by culture‐independent (pyrosequencing) culture‐dependent methods (16 S rRNA gene sequencing, pulsed...
Dietary changes are suggested to play a role in the increasing prevalence of allergic diseases and asthma. Short-chain fatty acids (SCFAs) metabolites present certain foods produced by microbes gut following fermentation fibers. SCFAs have been shown anti-inflammatory properties animal models. Our objective was investigate potential prevention allergy asthma.We analyzed SCFA levels high-performance liquid chromatography (HPLC) fecal samples from 301 one-year-old children birth cohort...
Initial neonatal gut colonisation is a crucial stage for developing healthy physiology, beneficially influenced by breast-feeding. Breast milk has been shown not only to provide nutrients and bioactive/immunological compounds, but also commensal bacteria, including gut-associated anaerobic Bifidobacterium spp. The aim of the present study was investigate bacterial diversity in breast milk, with emphasis on identifying obligate anaerobes. collected from seven mothers at three sampling points...
The establishment of a pioneer gut microbiota is increasingly recognized as crucial stage in neonatal development influencing health throughout life. While current knowledge mainly based on either culture or molecular analysis feces, we opted for comprehensive approach complementing with state-of-the-art methods. bacterial composition feces from seven healthy vaginally-delivered, breast-fed neonates was analyzed at days 4-6, 9-14 and 25-30 postnatal, using culture, 16S rRNA gene sequencing...
Eubacterium hallii is considered an important microbe in regard to intestinal metabolic balance due its ability utilize glucose and the fermentation intermediates acetate lactate, form butyrate hydrogen. Recently, we observed that E. capable of metabolizing glycerol 3-hydroxypropionaldehyde (3-HPA, reuterin) with reported antimicrobial properties. The key enzyme for 3-HPA conversion cobalamin-dependent glycerol/diol dehydratase PduCDE which also utilizes 1,2-propanediol (1,2-PD) propionate....
The high neuroactive potential of metabolites produced by gut microbes has gained traction over the last few years, with metagenomic-based studies suggesting an important role microbiota-derived γ-aminobutyric acid (GABA) in modulating mental health. Emerging evidence revealed presence glutamate decarboxylase (GAD)-encoding gene, a key enzyme to produce GABA, prominent human intestinal genus Bacteroides . Here, we investigated GABA production culture and metabolic assays combined comparative...
Abstract Background Reuterin produced from glycerol by Lactobacillus reuteri , a normal inhabitant of the human intestine, is broad-spectrum antimicrobial agent. It has been postulated that reuterin could play role in probiotic effects Lb. . active toward enteropathogens, yeasts, fungi, protozoa and viruses, but its effect on commensal intestinal bacteria unknown. Moreover reuterin's mode action not yet elucidated. Glutathione, powerful antioxidant, which also plays key detoxifying reactive...
Invasive aspergillosis (IA) is a well recognized, life-threatening infection in neutropenic patients and stem cell transplantation recipients. Early diagnosis important to achieve the best outcome for these patients; however, definite proof often difficult obtain due counterindicated invasive procedures.This study evaluated specificity sensitivity of detection galactomannan (GM) diagnostic prediction IA 347 children from Pediatric Hematology Service 450 Bone Marrow Transplantation Unit at...
Leuconostoc mesenteroides UL5 was found to produce a bacteriocin, referred as mesenterocin 5, active against Listeria monocytogenes strains but with no effect on several useful lactic acid bacteria. The antimicrobial substance is protein, since its activity completely destroyed following protease (pronase) treatment. However, it relatively heat stable (100 degrees C for 30 min) and partially denaturated by chloroform. inhibitory of the bacteriocin sensitive bacterial determined...