A5007210138- Asthma and respiratory diseases
- IL-33, ST2, and ILC Pathways
- Pediatric health and respiratory diseases
- Dermatology and Skin Diseases
- Gut microbiota and health
- Allergic Rhinitis and Sensitization
- Food Allergy and Anaphylaxis Research
- Probiotics and Fermented Foods
- Immune Cell Function and Interaction
- Neonatal Respiratory Health Research
- Mast cells and histamine
- Streptococcal Infections and Treatments
- Immune Response and Inflammation
- Infant Health and Development
- Breastfeeding Practices and Influences
- Stress Responses and Cortisol
- Pneumonia and Respiratory Infections
- T-cell and B-cell Immunology
- Respiratory and Cough-Related Research
- Mycobacterium research and diagnosis
- Immunotherapy and Immune Responses
- Reproductive System and Pregnancy
- Cannabis and Cannabinoid Research
- Contact Dermatitis and Allergies
- Eosinophilic Esophagitis
CK-CARE
2015-2024
University of Bern
2020-2024
University Hospital of Bern
2020-2024
University of Zurich
2011-2021
Université de franche-comté
2019
Centre National de la Recherche Scientifique
2019
University of Wollongong
2019
Hochgebirgsklinik Davos
2013-2016
University Children's Hospital Zurich
2008-2012
Boston Children's Hospital
2006-2007
Dietary changes are suggested to play a role in the increasing prevalence of allergic diseases and asthma. Short-chain fatty acids (SCFAs) metabolites present certain foods produced by microbes gut following fermentation fibers. SCFAs have been shown anti-inflammatory properties animal models. Our objective was investigate potential prevention allergy asthma.We analyzed SCFA levels high-performance liquid chromatography (HPLC) fecal samples from 301 one-year-old children birth cohort...
<h3>Background</h3> Intestinal homoeostasis is dependent on immunological tolerance to the microbiota. <h3>Objective</h3> To (1) determine if a probiotic could induce Foxp3 T cells in humans; (2) elucidate molecular mechanisms, which are involved induction of by human dendritic cells. <h3>Design</h3> Cytokine secretion and expression were assessed volunteers following <i>Bifidobacterium infantis</i> feeding. Monocyte-derived (MDDCs), myeloid (mDCs) plasmacytoid (pDCs) incubated vitro with...
Atopic dermatitis is an inflammatory, pruritic skin disease that often occurs in early infancy with a chronic course. However, specific description of subtypes atopic depending on the timing onset and progression childhood lacking.To identify different phenotypes using definition based symptoms before age 6 years to determine whether some are more at risk for developing other allergic diseases.The Protection Against Allergy Study Rural Environments (PASTURE) European birth cohort where...
Abstract In order to improve targeted therapeutic approaches for asthma patients, insights into the molecular mechanisms that differentially contribute disease phenotypes, such as obese asthmatics or severe asthmatics, are required. Here we report immunological and microbiome alterations in (n = 50, mean age 45), non-obese 53, 40), non-asthmatics 51, 44) their healthy counterparts 48, 39). Obesity is associated with elevated proinflammatory signatures, which enhanced presence of asthma....
Abstract We performed a systematic review to investigate the current evidence on association between allergic diseases and short chain fatty acids (SCFAs), which are microbially produced suggested as one mechanism how gut microbiome affects risk of diseases. Medline, Embase Web Science were searched from data inception until September 2022. identified 37 papers, 17 investigated prenatal or early childhood SCFAs development in childhood, 20 assessed patients with pre‐existing Study design,...
Summary. Cow oocytes and preimplantation embryos were cultured in medium containing radiolabelled methionine the proteins synthesized analysed by one-dimensional electrophoresis fluorography. Marked changes pattern of synthesis observed at 8–16-cell stage development. Quantitatively, a gradual decrease rate protein occurred between zygote 8-cell then increased progressively to blastocyst stage. Incorporation uridine into RNA was first detected 16-cell Taken together, these results suggest...
ABSTRACT The immune-modulating properties of certain bifidobacterial strains, such as Bifidobacterium longum subsp. 35624 ( B. 35624), have been well described, although the strain-specific molecular characteristics associated with immune-regulatory activity are not defined. It has previously demonstrated that produces a cell surface exopolysaccharide (sEPS), and in this study, we investigated role played by influencing host immune response. induced relatively low levels cytokine secretion...
Abstract The prevalence of allergic diseases such as rhinitis, asthma, food allergy, and atopic dermatitis has increased dramatically during the last decades, which is associated with altered environmental exposures lifestyle practices. purpose this review was to highlight potential role for dietary fatty acids, in prevention management these disorders. In addition their nutritive value, acids have important immunoregulatory effects. Fatty acid‐associated biological mechanisms, human...
Allergies are a serious public health issue, and prevalences rising worldwide. The role of antibiotics in the development allergies has repeatedly been discussed, as results remain inconsistent. aim this study was to investigate association between pre- post-natal antibiotic exposure subsequent (atopic dermatitis, food allergy, asthma, atopic sensitization allergic rhinitis).A total 1080 children who participated European birth cohort (PASTURE) were included analysis. Data on during...
The acquisition of the infant gut microbiota is key to establishing a host-microbiota symbiosis. Microbially produced metabolites tightly interact with immune system, and fermentation-derived short-chain fatty acid butyrate considered an important mediator linked chronic diseases later in life. intestinal butyrate-forming bacterial population taxonomically functionally diverse includes endospore formers high transmission potential. Succession, contribution butyrate-producing taxa during...