A5084181228- Asthma and respiratory diseases
- Food Allergy and Anaphylaxis Research
- Allergic Rhinitis and Sensitization
- Dermatology and Skin Diseases
- Eosinophilic Esophagitis
- Vitamin D Research Studies
- Pediatric health and respiratory diseases
- Digestive system and related health
- Child Nutrition and Feeding Issues
- IL-33, ST2, and ILC Pathways
- Delphi Technique in Research
- Esophageal and GI Pathology
- Obesity, Physical Activity, Diet
- Adrenal Hormones and Disorders
- Congenital Diaphragmatic Hernia Studies
- Neuroendocrine regulation and behavior
- Urticaria and Related Conditions
- Gastroesophageal reflux and treatments
- Maternal Mental Health During Pregnancy and Postpartum
- Health, Environment, Cognitive Aging
- Pregnancy and Medication Impact
- Contact Dermatitis and Allergies
- Consumer Attitudes and Food Labeling
- Menstrual Health and Disorders
- Eating Disorders and Behaviors
Singapore Institute for Clinical Sciences
2020-2024
Agency for Science, Technology and Research
2020-2024
Murdoch Children's Research Institute
2014-2021
The University of Melbourne
2015-2019
Royal Children's Hospital
2015-2018
Abstract We performed a systematic review to investigate the current evidence on association between allergic diseases and short chain fatty acids (SCFAs), which are microbially produced suggested as one mechanism how gut microbiome affects risk of diseases. Medline, Embase Web Science were searched from data inception until September 2022. identified 37 papers, 17 investigated prenatal or early childhood SCFAs development in childhood, 20 assessed patients with pre‐existing Study design,...
Abstract Atopic dermatitis (AD) is a chronic inflammatory skin disorder, with highly variable prevalence worldwide. Recent evidence, however, has shown an increase in the Asia Pacific region. Nevertheless, most of published literature focused mainly on Western populations, and only few clinical trials have included subgroups other ethnic populations. Reasons for observed geographical differences AD are not well established. This calls into question need better understanding pathogenesis...
Abstract Background In Western countries, Asian children have higher food allergy risk than Caucasian children. The early‐life environmental exposures for this discrepancy are unclear. We aimed to compare prevalence of and associated factors between in Singapore Australia. Methods studied the Growing Up Towards healthy Outcomes (GUSTO) birth cohort (n = 878) ancestry HealthNuts 314). Food was defined as a positive SPT ≥3 mm egg or peanut AND either convincing history IgE‐mediated reaction at...
Asian children born in Australia have higher rates of eczema and nut allergy than non-Asian children. However, it is not known whether this country birth differential exists for other allergies or anaphylaxis risk.We investigated the influence maternal child's on prevalence parent-reported eczema, asthma, food being diagnosed by a doctor as "at risk anaphylaxis."We assessed relationship between mother child using 2010 School Entrant Health Questionnaire, completed 57 005 5-year old (85.8%...
The heterogeneity of childhood atopic dermatitis (AD) underscores the need to understand latent phenotypes that may inform risk stratification and disease prognostication.To identify AD trajectories across first 8 years life investigate factors associated with each trajectory their relationships other comorbidities.Data were collected prospectively from 1152 mother-offspring dyads in Growing Up Singapore Towards healthy Outcomes (GUSTO) cohort ages 3 months years. was defined based on...
Most previous research on the environmental epidemiology of childhood atopic eczema, rhinitis and wheeze is limited in scope risk factors studied. Our study adopted a machine learning approach to explore role exposome starting already preconception phase.
Birth during pollen seasons may influence food allergy risk but no study has assessed exposure. Using the HealthNuts population-based cohort of 5276 infants, we grass exposures, in utero and up to first 6 months life, on hen's egg, sesame peanut outcomes at 12 months. Cumulative exposure 7 days life increased sensitization aMOR (adjusted multinomial odds ratio) = 1.21 (95% CI: 1.01-1.44). Exposure between 4-6 egg 1.02 1.004-1.04) all foods 1.003-1.04). Grass was associated with challenge...
Maternal history of inflammatory conditions has been linked to offspring developmental and behavioural outcomes. This phenomenon may be explained by the maternal immune activation (MIA) hypothesis, which posits that dysregulation gestational environment affects foetal neurodevelopment. The timing inflammation is critical. We aimed understand asthma symptoms during pregnancy, in contrast with paternal same period, on child behaviour problems executive function a population-based cohort.
The coronavirus disease 2019 (COVID-19) pandemic caused significant disruptions to health care services and impacts on patients with atopic dermatitis (AD) and/or food allergy (FA).We evaluated the impact of COVID-19 AD/FA patients.A comprehensive systematic literature search was conducted from December 2022. Screening data extraction were done following Preferred Reporting Items for Systematic Reviews Meta-analysis (PRISMA) guidelines, Mixed Methods Appraisal Tool, or MMAT, used assess risk...