A5047460210- Breastfeeding Practices and Influences
- Birth, Development, and Health
- Gestational Diabetes Research and Management
- Child Nutrition and Feeding Issues
- Obesity, Physical Activity, Diet
- Infant Nutrition and Health
- Pregnancy and preeclampsia studies
- Nutritional Studies and Diet
- Infant Development and Preterm Care
- Folate and B Vitamins Research
- Eating Disorders and Behaviors
- Child Nutrition and Water Access
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Maternal Mental Health During Pregnancy and Postpartum
- Neuroscience and Neuropharmacology Research
- Fatty Acid Research and Health
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Gut microbiota and health
- Toxic Organic Pollutants Impact
- Healthcare Systems and Practices
- Neuroscience of respiration and sleep
- Effects of Radiation Exposure
- Esophageal and GI Pathology
- Advanced Proteomics Techniques and Applications
- Antimicrobial Peptides and Activities
National University of Singapore
2015-2024
National University Health System
2015-2024
First People's Hospital of Yunnan Province
2024
Kunming University of Science and Technology
2024
Jiamusi University
2022
Chinese PLA General Hospital
2021
Institute of Biological Chemistry, Academia Sinica
2020
Army Medical University
2018
London Rebuilding Society
2014
Chinese People's Liberation Army
2012-2013
Saw Swee Hock School of Public Health, National University Singapore, Department Paediatrics, Yong Loo Lin Medicine, Obstetrics & Gynaecology, Health System, Singapore Institute for Clinical Sciences, Agency Science and Technology Research (A*STAR), Brenner Centre Molecular Liggins Institute, Auckland, New Zealand, Medical Council Lifecourse Epidemiology Unit, Southampton, UK, NIHR Southampton Biomedical Centre, Hospital NHS Foundation Trust, Biostatistics KK Women’s Children’s Hospital,
Intake of n-3 polyunsaturated fatty acids (n-3 PUFAs) may protect against mild cognitive impairment (MCI). However, there is still a lack the PUFAs intervention in elderly with MCI China. The aim present study was to investigate effect PUFA supplementation on function Chinese MCI.Eighty six individuals aged 60 years or older were randomly assigned receive either (480 mg DHA and 720 EPA per day, n = 44) placebo (olive oil, 42) capsules. changes functions assessed using Basic Cognitive...
Objective: Dysbiosis of gastric microbiota such as Helicobacter pylori plays a significant role in pathogenesis and progression cancer. Our aim was to evaluate the composition functional effects superficial gastritis (SG) advanced adenocarcinoma (GC). Methods: We carried out shotgun metagenomic sequencing on wash samples from 6 patients with GC 5 SG. The taxonomic profiled using MetaPhlAn2 gene pathway HUMAnN2. Differences microbial pathways between two patient groups were assessed via...
To explore the associations between type of milk feeding (the "nutrients") and mode breast "nursing") with child cognition. Healthy children from GUSTO (Growing Up in Singapore Toward healthy Outcomes) cohort participated repeated neurodevelopmental assessments 6 54 months. For "nutrients", we compared exclusively bottle-fed according to received: formula only (n = 296) vs some/all 73). "nursing", included who were fully fed milk, comparing those directly at 59) partially/completely by...
Appetitive traits in childhood such as food responsiveness and enjoyment of have been associated with body mass index (BMI) later childhood. However, data on appetitive during infancy relation to BMI are sparse. We aimed relate subsequent weight gain up 24 months age. Data 210 infants from the Singapore GUSTO mother-offspring cohort was obtained. The Baby Eating Behavior Questionnaire (BEBQ) Child (CEBQ) were administered mothers when their offspring aged 3 12 respectively. Height measured...
Studies examining direct vs. expressed breast milk feeding are scarce. We explored the predictors of mode breastfeeding and its association with duration in a multi-ethnic Asian population.We included 541 mother-infant pairs from Growing Up Singapore Toward healthy Outcomes cohort. Mode (feeding directly at breast, (EBM) only, or mixed (a combination former 2 modes)) was ascertained three months postpartum. Ordinal logistic regression analyses identified expression. Cox models examined...
An intervention study was performed to determine if supplement containing folic acid, vitamin B6, and B12 could improve cognitive function lower homocysteine in middle-aged elderly patients with hyperhomocysteinemia.One hundred four participants hyperhomocysteinemia were recruited Tianjin, China, aged 55-94 years old. Fifty-seven individuals included the group (vitamin B group, which received 800 µg/day of folate, 10 mg B6 25 µg B12) 47 placebo group. The endpoint improvement as evaluated by...
Abstract Background Many countries in Asia report low breastfeeding rates and the risk factors for early weaning are not well studied. We assessed prevalence, duration, mode of (direct or expressed) among mothers three Asian ethnic groups. Methods Participants were 1,030 Singaporean women recruited during pregnancy. Data collected included experiences, breastfeeding. Full was defined as intake breast milk, with without water. Cox regression models used to identify associated discontinuation...
Background: Infant body mass index (BMI) peak has received much interest recently as a potential predictor of future obesity and metabolic risk. No studies, however, have examined infant BMI in Asian populations, whom the risk disease is higher.
We investigated body mass index (BMI) trajectories in the first 2 years of life 1170 children from an Asian mother-offspring cohort Singapore, and examined their predictors associations with childhood cardio-metabolic risk measures at 5 years. Latent class growth mixture modelling analyses were performed to identify distinct BMI z-score (BMIz) trajectories. Four identified: 73.2%(n = 857) showed a normal BMIz trajectory, 13.2%(n 155) stable low-BMIz 8.6%(n 100) high-BMIz trajectory 5.0%(n...
The human gut microbiota develops soon after birth and can acquire inter-individual variation upon exposure to intrinsic environmental cues. However, has not been comprehensively assessed in a multi-ethnic study. We studied longitudinal cohort of 106 infants three Asian ethnicities (Chinese, Malay, Indian) that resided the same geographical location (Singapore). Specific temporal influences ethnicity, mode delivery, breastfeeding status, gestational age, birthweight, gender, maternal...
Abstract Background Confinement (restrictions placed on diet and practices during the month right after delivery) represents a key feature of Asian populations. Few studies, however, have focused specifically ethnic differences in confinement practices. This study assesses three groups multi‐ethnic population. Methods Participants were part prospective birth cohort that recruited 1,247 pregnant women (57.2% Chinese, 25.5% Malay, 17.3% Indian) their first trimester. The 1,220 participants...
OBJECTIVE We prospectively evaluated plasma amino acids (AAs) in early pregnancy and midpregnancy their interplay with phospholipid fatty (FAs) association gestational diabetes mellitus (GDM) risk. RESEARCH DESIGN AND METHODS From a longitudinal cohort of 2,802 individuals, concentrations 24 AAs at 10–14 15–26 weeks (GW) were assessed among 107 GDM case subjects 214 non-GDM control subjects. estimated adjusted odds ratios (OR) 95% CI for the associations joint FAs risk, adjusting risk...
Preeclampsia (PE) is a severe pregnancy complication characterized by significant alterations in coagulation function. This study aims to analyze the correlation between function, platelet parameters, and outcomes PE patients. Clinical data, along with blood urine samples, were collected from 168 patients 128 healthy pregnant women. General demographic laboratory testing data recorded, maternal fetal followed up. Data analyzed using Kaplan-Meier logistic regression analyses. In mild...