A5103189761- Glaucoma and retinal disorders
- Ophthalmology and Visual Impairment Studies
- Hormonal Regulation and Hypertension
- Breast Cancer Treatment Studies
- Cancer Genomics and Diagnostics
- Adrenal Hormones and Disorders
- Bone health and osteoporosis research
- Blood Pressure and Hypertension Studies
- Bone and Joint Diseases
- Potassium and Related Disorders
- Child Nutrition and Feeding Issues
- Adrenal and Paraganglionic Tumors
- Breastfeeding Practices and Influences
- COVID-19 diagnosis using AI
- COVID-19 and Mental Health
- Hip and Femur Fractures
- Breast Lesions and Carcinomas
- Traumatic Brain Injury and Neurovascular Disturbances
- Retinal Diseases and Treatments
- Child Nutrition and Water Access
- SARS-CoV-2 detection and testing
- Nosocomial Infections in ICU
- Global Cancer Incidence and Screening
- Tracheal and airway disorders
- Dental Research and COVID-19
Changi General Hospital
2009-2024
SingHealth
2020-2021
National University Health System
2013-2019
National University of Singapore
2013-2019
Duke-NUS Medical School
2017
To explore the associations between type of milk feeding (the "nutrients") and mode breast "nursing") with child cognition. Healthy children from GUSTO (Growing Up in Singapore Toward healthy Outcomes) cohort participated repeated neurodevelopmental assessments 6 54 months. For "nutrients", we compared exclusively bottle-fed according to received: formula only (n = 296) vs some/all 73). "nursing", included who were fully fed milk, comparing those directly at 59) partially/completely by...
The outbreak of COVID-19 has precipitated international lockdown measures to curb disease transmissions. closure public activity spaces as well changes in pandemic workload may disrupt healthcare workers' physical and self-care routines. We sought examine the association between levels mental health burden workers during Singapore. This cross-sectional study comprised an multidomain survey that was administered digitally 707 17 May 18 June 2020. Exercise frequency, duration intensity these...
Serum tumour markers, cancer antigen 15-3 (CA 15-3) and carcinoembryonic (CEA) are not routinely recommended for detecting breast recurrence monitoring treatment. In this study, we aim to evaluate the diagnostic accuracy of absolute CA CEA levels report on clinical utility marker velocity in surveillance.
Iron deficiency is the most prevalent nutrient and common cause of anaemia worldwide. Because increased iron requirements during pregnancy, can lead to maternal reduced newborn stores. We examined proportion risk factors among pregnant women in a developed Asian country. Within prospective cohort Singapore, 985 were assessed for status at 26–28 weeks' gestation, with plasma ferritin soluble transferrin receptor (sTfR) measurements. was determined according concentrations ≥30 μg/L (iron...
Background Self-sampling for SARS-CoV-2 would significantly raise testing capacity and reduce healthcare worker (HCW) exposure to infectious droplets personal, protective equipment (PPE) use. Methods We conducted a diagnostic accuracy study where subjects with confirmed diagnosis of COVID-19 (n = 401) healthy volunteers 100) were asked self-swab from their oropharynx mid-turbinate (OPMT), self-collect saliva. The results these samples compared an OPMT performed by HCW in the same patient at...
Abstract Purpose To determine if eye size and shape at birth are associated with refractive error 3 years later. Methods A subset of 173 full‐term newborn infants from the Growing Up in Singapore Towards healthy Outcomes ( GUSTO ) cohort underwent magnetic resonance imaging MRI to measure dimensions internal eye. Eye was assessed by an oblateness index, calculated as 1 − (axial length/width) or length/height). Cycloplegic autorefraction (Canon Autorefractor RK ‐F1) optical biometry IOLM...
Introduction Triglyceride-rich remnant lipoproteins (TRLs) are considered atherogenic due to the presence of cholesterol, which is transported by apolipoprotein B. In clinical practice, concentration TRLs can be estimated calculating cholesterol or non-HDL levels. Aim This study aims investigate proportion patients who have low LDL (LDL-C) but elevated concentration, stratified hypertriglyceridaemia and ethnicity, using real-world hospital data. Our secondary aim with levels...
Studies find surgery superior to medications in the treatment of primary aldosteronism (PA). It would be ideal compare surgical and medical therapy patients with unilateral PA only, who have option between these modalities. However, this is challenging as most on adrenal vein sampling (AVS) undergo surgery.To outcomes confirmed or likely PA.Retrospective cohort study 274 managed at two referral centres from 2000 2019.154 identified using AVS a validated clinical prediction model were treated...
Introduction: Long-term proton pump inhibitor (PPI) use has been associated with hypomagnesemia. It is unknown how frequently PPI implicated in patients severe hypomagnesemia, and its clinical course or risk factors. Methods: All hypomagnesemia from 2013 to 2016 a tertiary center were assessed for likelihood of PPI-related using Naranjo algorithm, we described the course. The characteristics each case was compared three controls on long-term without assess factors developing Results: Amongst...
To determine the eye size and shape obtained by magnetic resonance imaging (MRI), to associations with antenatal factors in newborn children.A subset of 173 full-term children from Growing Up Singapore Towards Healthy Outcomes (GUSTO) birth cohort underwent MRI. Eye volume surface area were measured. was assessed qualitatively three-dimensional models, quantitatively measurement longitudinal axial length (AL, posterior corneal retinal surface), horizontal width vertical height internal along...
Introduction Studies show trabecular bone score (TBS) may provide information regarding quality independent of mineral density (BMD) in type 2 diabetes (DM2) patients. We analyzed our Southeast Asian severe osteoporotic hip fracture patients to study these differences. Methods conducted a retrospective cross-sectional analysis subjects admitted Changi General Hospital, Singapore with fractures from 2014–2017 who had BMD performed. Electronic records were reviewed and classified as having...
Introduction: We presented the key findings from Singapore’s Changi General Hospital Breast Centre’s lymphedema surveillance strategy that used patients’ reported symptoms, standard arm circumference measurements and clinical assessment in diagnosis of breast cancer-related (BCRL). Our secondary aim was to highlight discuss important elements a can be implemented track this outcome measure cancer treatment for future research. Method: conducted cross-sectional study 511 patients assess...
Abstract Our study sought to examine the impact of pandemic and Circuit-breaker (CB) measures on dietary behaviours healthcare workers (HCW). In addition, association between self-regulatory eating psychological stress was explored. employed a cross-sectional anonymous survey that examined demographics, habits, (SR) their levels (HCWs) before during Circuit Breaker in Singapore . The conducted over four weeks from May 17 June 18, 2020. Snowball sampling performed final week. A total 707...
Abstract Introduction Patients with primary aldosteronism (PA) have increased cardiovascular risk, and there are concerns about the efficacy of medical therapy. Objective We aimed to assess long-term tolerability therapy in PA patients. Methods conducted a retrospective study on 201 patients treated (spironolactone, eplerenone, or amiloride) from 2000 2020 at 2 tertiary centers. Clinical biochemical control side effects were assessed. Results Among 155 medications, 57.4% achieved blood...
Abstract Background In October 2019, surgeons from Changi General Hospital (CGH) Breast Centre delivered a series of health talk for its employees to assess the knowledge and perception breast cancer screening improve level related amongst institution’s healthcare workers. This was enable CGH, provider not only care our patients, but also look after staff. Methods 141 hospital staff attended 40-min followed by an open question answer forum. Pre post surveys were conducted gauge knowledge,...
ABSTRACT Bisphosphonates (BP) are the most commonly prescribed effective form of osteoporosis treatment with adverse effects associated prolonged use such as atypical femoral fractures (AFF). Asians have an elevated risk AFF at 5 to 6 times those whites and Hispanics. In this study, we characterize factors its mortality in a single center Singapore. We conducted cohort study subjects older than 50 years admitted Changi General Hospital (CGH), Singapore, fragility subtrochanteric from 2009...
In addition to increased cardiovascular risk, patients with primary aldosteronism (PA) also suffer from impaired health-related quality of life (HRQoL) and psychological symptoms. We assessed for changes in HRQoL depressive symptoms a cohort Asian PA, after surgical medical therapy.Thirty-four PA were prospectively recruited completed questionnaires 2017 2020. was using RAND-36 EQ-5D-3L, Beck Depression Inventory (BDI-II) at baseline, 6 months, 1 year post-treatment.At post-treatment,...
Abstract Background Ductal carcinoma in situ (DCIS) is an established precursor to invasive ductal (IDC) and its coexistence with IDC appear favor reduced biological aggressiveness. Its prognostic implication ability affect clinical outcome has been understudied Asia. This study aims explore if concomitant DCIS affects the behavior outcomes among Asians. Aim Stages I III breast cancer patients histological proven IDC, diagnosed treated a single institution from June 1, 2004 30, 2014 were...
Introduction Patients who had a stroke are at increased risk of sepsis, dehydration and fluctuations in blood pressure, which may result acute kidney injury (AKI). The impact AKI on long-term survival has not been studied well. Objective We aimed to identify incidence during stroke, follow-up period its development chronic disease (CKD). Design, setting participants Retrospective analysis patients admitted the rehabilitation facility Changi General Hospital, Singapore, between June 2008 May...
The anion gap (AG) is often used to evaluate acid-base disorders. reference interval for normal AG differentiate between raised (gap) or (non-gap) acidosis. Historically accepted values may not be valid with the evolution of modern analytical techniques and requires revalidation.To determine based on current laboratory techniques.During a health-screening exercise, 284 participants no major illnesses volunteered surplus blood analysis. samples were tested in an internationally accredited...