A5037176206- Hormonal Regulation and Hypertension
- Diet and metabolism studies
- Adrenal and Paraganglionic Tumors
- Diabetes Treatment and Management
- Diabetes Management and Research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Adrenal Hormones and Disorders
- Hormonal and reproductive studies
- Liver Disease Diagnosis and Treatment
- Metabolism, Diabetes, and Cancer
- Sexual function and dysfunction studies
- Pituitary Gland Disorders and Treatments
- Pharmacology and Obesity Treatment
- Urinary Bladder and Prostate Research
- Blood Pressure and Hypertension Studies
- Biochemical Analysis and Sensing Techniques
- Diet, Metabolism, and Disease
- Bone health and osteoporosis research
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Hip and Femur Fractures
- Gastrointestinal motility and disorders
- Vitamin D Research Studies
- Eating Disorders and Behaviors
- Muscle metabolism and nutrition
- Adipose Tissue and Metabolism
Changi General Hospital
2014-2024
Singapore General Hospital
2023
SingHealth
2020-2021
The University of Adelaide
2009-2016
Royal Adelaide Hospital
2009-2016
Randomized trials demonstrated a lower risk of cardiovascular (CV) events with sodium-glucose cotransporter-2 inhibitors (SGLT-2i) in patients type 2 diabetes (T2D) at high CV risk. Prior real-world data suggested similar SGLT-2i effects T2D broader profile, but these studies focused on heart failure and death were limited to the United States Europe.The purpose this study was examine broad range outcomes initiated versus other glucose-lowering drugs (oGLDs) across 6 countries Asia Pacific,...
We compared the effects of weight loss induced with glucagon-like peptide-1 agonist liraglutide, that lifestyle modification, followed by maintenance after discontinuing intervention, in obese adults non-alcoholic fatty liver disease (NAFLD).Thirty (mean age 40.7 ± 9.1 years, BMI 33.2 3.6 kg/m2 , 90% male) NAFLD defined as fat fraction (LFF) > 5% on magnetic resonance imaging without other causes hepatic steatosis were randomized to a supervised programme energy restriction plus...
We previously established that the intestinal sweet taste receptors (STRs), T1R2 and T1R3, were expressed in distinct epithelial cells human proximal intestine their transcript levels varied with glycemic status patients type 2 diabetes. Here we determined whether STR expression was 1) acutely regulated by changes luminal systemic glucose levels, 2) disordered diabetes, 3) linked to absorption. Fourteen healthy subjects 13 diabetes studied twice, at euglycemia (5.2 ± 0.2 mmol/L) or...
We compared the effects of weight loss induced by glucagon‐like peptide 1‐agonist liraglutide with a structured lifestyle intervention in obese adults non‐alcoholic fatty liver disease ( NAFLD ). Obese (body mass index ≥30 kg/m 2 , mean 96.0 ± 16.3 kg) non‐diabetic Asian adults, diagnosed fat fraction LFF ) ≥ 5.5% on magnetic resonance imaging without other causes hepatic steatosis, were randomized to supervised program dieting (restriction 400 kilocalories/d) plus moderate‐intensity aerobic...
Objectives To determine whether tight glycemic control is associated with greater risk of hip fractures in individuals being treated for type 2 diabetes mellitus. Design Case–control study. Setting Tertiary hospital. Participants Cases were selected from all mellitus admitted between 2005 and 2010 to C hangi G eneral H ospital fracture (N = 932). included if their glycosylated hemoglobin ( b A 1c) had been measured within 3 months the they undergoing treatment oral hypoglycemic medications...
The short-acting glucagon-like peptide 1 receptor agonist exenatide reduces postprandial glycemia, partly by slowing gastric emptying, although its impact on small intestinal function is unknown. In this study, 10 healthy subjects and patients with type 2 diabetes received intravenous (7.5 μg) or saline (-30 to 240 min) in a double-blind randomized crossover design. Glucose (45 g), together 5 g 3-O-methylglucose (3-OMG) 20 MBq (99m)Tc-sulfur colloid (total volume 200 mL), was given...
The adipokines chemerin and adiponectin are reciprocally related in the pathogenesis of insulin resistance inflammation obesity. Weight loss increases reduces chemerin, resistance, inflammation, but effects caloric restriction physical activity difficult to separate combined lifestyle modification. We compared diet- or exercise-induced weight on adiponectin, obese men. Eighty abdominally Asian men (body mass index [BMI] ≥ 30 kg/m(2), waist circumference [WC] 90 cm, mean age 42.6 years) were...
Secondary hypertension occurs in a significant proportion of adult patients (~10%). In young patients, renal causes (glomerulonephritis) and coarctation the aorta should be considered. older primary aldosteronism, obstructive sleep apnoea artery stenosis are more prevalent than previously thought. Primary aldosteronism can screened by taking morning aldosterone renin levels, considered with severe, resistant or hypokalaemia-associated hypertension. Symptoms sought. Worsening function after...
Abstract Background Familial partial lipodystrophy (FPLD) is an inherited disorder of white adipose tissue that causes premature cardiometabolic disease. There no clear diagnostic criteria for FPLD, and this may explain the under-detection condition. Aim This pilot study aimed to describe clinical features women with FPLD explore value measurements could be useful in diagnosis. Methods In 8 4 controls, skinfold measurements, DXA whole-body MRI were undertaken. Results Whole genome sequencing...
Prediction models have been developed to predict either unilateral or bilateral primary aldosteronism, and these not validated externally. We aimed develop a simplified score both subtypes validate this externally.Our development cohort was taken from 165 patients who underwent adrenal vein sampling (AVS) in two Asian tertiary centres. Unilateral disease determined using AVS postoperative outcome. Multivariable analysis used construct prediction models. our tool European of 97 enrolled the...
There is a global pandemic of type 2 diabetes mellitus (T2DM), especially in Asia. Singapore has prevalence T2DM at 10.5%, which higher than the world average 8.8%. Multiple studies have shown that multidisciplinary, team-based, coordinated care been associated with improved measures quality and reduced healthcare utilization. Patients poor glycemic control nephropathy are highest risk developing cardiovascular complications renal failure. In this study, we aimed to investigate impact...
Abstract Background Randomized, controlled cardiovascular outcome trials may not be fully representative of the management patients with type 2 diabetes across different geographic regions. We conducted analyses data from multinational CVD-REAL consortium to determine association between initiation sodium–glucose cotransporter-2 inhibitors (SGLT-2i) and outcomes, including subgroup based on patient characteristics. Methods De-identified health records 13 countries three continents were used...
To describe the magnetic resonance (MR) imaging findings associated with severe hypoglycemia after consumption of an illegal sexual enhancement product (Power 1 Walnut) adulterated glibenclamide, oral hypoglycemic agent used to treat diabetes mellitus.Institutional review board approval was obtained for this retrospective study. Records in eight male patients unknown cause, without prior treatment diabetes, and positive blood toxicology results glibenclamide were reviewed. MR included...
<bold>Objective:</bold> Migrant workers, a marginalized and under-resourced population, are vulnerable to coronavirus disease 2019 (COVID-19) due limited healthcare access. Moreover, metabolic diseases—such as diabetes mellitus (DM), hypertension, hyperlipidemia—predispose severe complications mortality from COVID-19. We investigate the prevalence consequences of undiagnosed illnesses, particularly DM pre-diabetes, in international migrant workers with <bold>Methods:</bold> In this...
Introduction Primary aldosteronism (PA) is associated with increased risk of cardiovascular events. However, treatment PA has not been shown to improve left ventricular (LV) systolic function using the conventional assessment LV ejection fraction (LVEF). We aim use speckle-tracking echocardiography assess for improvement in subclinical after PA. Methods prospectively recruited 57 patients PA, who underwent 24-h ambulatory blood pressure (BP) measurements and echocardiography, including...
Studies find surgery superior to medications in the treatment of primary aldosteronism (PA). It would be ideal compare surgical and medical therapy patients with unilateral PA only, who have option between these modalities. However, this is challenging as most on adrenal vein sampling (AVS) undergo surgery.To outcomes confirmed or likely PA.Retrospective cohort study 274 managed at two referral centres from 2000 2019.154 identified using AVS a validated clinical prediction model were treated...
Introduction: Long-term proton pump inhibitor (PPI) use has been associated with hypomagnesemia. It is unknown how frequently PPI implicated in patients severe hypomagnesemia, and its clinical course or risk factors. Methods: All hypomagnesemia from 2013 to 2016 a tertiary center were assessed for likelihood of PPI-related using Naranjo algorithm, we described the course. The characteristics each case was compared three controls on long-term without assess factors developing Results: Amongst...