A5079564889- Lipoproteins and Cardiovascular Health
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cancer, Lipids, and Metabolism
- Lipid metabolism and disorders
- Health Systems, Economic Evaluations, Quality of Life
- Liver Disease Diagnosis and Treatment
- Cholesterol and Lipid Metabolism
- Pharmaceutical Economics and Policy
- Cardiovascular Health and Disease Prevention
- Diet and metabolism studies
- Blood Pressure and Hypertension Studies
- Antiplatelet Therapy and Cardiovascular Diseases
- Atherosclerosis and Cardiovascular Diseases
- Adipokines, Inflammation, and Metabolic Diseases
- Fatty Acid Research and Health
- Diet, Metabolism, and Disease
- Cardiovascular Disease and Adiposity
- Health and Medical Research Impacts
- Cardiac Imaging and Diagnostics
- Diabetes Treatment and Management
- Chronic Kidney Disease and Diabetes
- Peroxisome Proliferator-Activated Receptors
- Acute Myocardial Infarction Research
- Cardiovascular Function and Risk Factors
- Systemic Lupus Erythematosus Research
Royal Perth Hospital
2016-2025
The University of Western Australia
2016-2025
Brigham and Women's Hospital
2015-2025
Harvard University
2015-2025
The University of Sydney
2024
Universidade de São Paulo
2024
GTx (United States)
2021-2024
Monash University
2023-2024
Icahn School of Medicine at Mount Sinai
2024
Sorbonne Université
2024
The first aim was to critically evaluate the extent which familial hypercholesterolaemia (FH) is underdiagnosed and undertreated. second provide guidance for screening treatment of FH, in order prevent coronary heart disease (CHD).Of theoretical estimated prevalence 1/500 heterozygous <1% are diagnosed most countries. Recently, direct a Northern European general population approximately 1/200 with FH. All reported studies document failure achieve recommended LDL cholesterol targets large...
AimsThe aims of the study were, first, to critically evaluate lipoprotein(a) [Lp(a)] as a cardiovascular risk factor and, second, advise on screening for elevated plasma Lp(a), desirable levels, and therapeutic strategies.
Abstract
In addition to their pivotal role in thrombosis and wound repair, platelets participate inflammatory responses. We investigated the of autoimmune disease rheumatoid arthritis. identified platelet microparticles--submicrometer vesicles elaborated by activated platelets--in joint fluid from patients with arthritis other forms arthritis, but not osteoarthritis. Platelet microparticles were proinflammatory, eliciting cytokine responses synovial fibroblasts via interleukin-1. Consistent these...
Homozygous familial hypercholesterolaemia (HoFH) is a rare life-threatening condition characterized by markedly elevated circulating levels of low-density lipoprotein cholesterol (LDL-C) and accelerated, premature atherosclerotic cardiovascular disease (ACVD). Given recent insights into the heterogeneity genetic defects clinical phenotype HoFH, availability new therapeutic options, this Consensus Panel on Familial Hypercholesterolaemia European Atherosclerosis Society (EAS) critically...
To critically evaluate the clinical implications of use non-fasting rather than fasting lipid profiles and to provide guidance for laboratory reporting abnormal or profiles.Extensive observational data, in which random have been compared with those determined under conditions, indicate that maximal mean changes at 1-6 h after habitual meals are not clinically significant [+0.3 mmol/L (26 mg/dL) triglycerides; -0.2 (8 total cholesterol; LDL +0.2 calculated remnant non-HDL cholesterol];...
This 2022 European Atherosclerosis Society lipoprotein(a) [Lp(a)] consensus statement updates evidence for the role of Lp(a) in atherosclerotic cardiovascular disease (ASCVD) and aortic valve stenosis, provides clinical guidance testing treating elevated levels, considers its inclusion global risk estimation. Epidemiologic genetic studies involving hundreds thousands individuals strongly support a causal continuous association between concentration outcomes different ethnicities; is factor...
Context: The diagnosis of familial hypercholesterolemia (FH) can be made using the Dutch Lipid Clinic Network criteria. This employs personal and family history premature coronary artery disease presence a pathogenic mutation in low-density lipoprotein receptor (LDLR) apolipoprotein B (APOB) genes. Objective: We employed this tool to investigate prevalence FH associations between cholesterol-lowering medication Copenhagen General Population Study. Setting: study was an unselected,...
Brachial artery ultrasound is commonly employed for noninvasive assessment of endothelial function. However, analysis observer dependent and susceptible to errors. We describe studies on a computerized edge-detection wall-tracking software program allow more accurate reproducible measurement. In study 1, three purpose-built Perspex phantom arteries, 3.00, 4.00, 6.00 mm in diameter, were measured with the software. There was mean bias 11 μm ( P < 0.001 at each level) between known values;...
The normal synovium forms a membrane at the edges of joints and provides lubrication nutrients for cartilage. In rheumatoid arthritis, is site inflammation, it participates in an organized tissue response that damages cartilage bone. We identified cadherin-11 as essential development synovium. Cadherin-11-deficient mice have hypoplastic synovial lining, display disorganized reaction to are resistant inflammatory arthritis. Cadherin-11 therapeutics prevent reduce arthritis mouse models. Thus,...