A5021777258- Lipoproteins and Cardiovascular Health
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cancer, Lipids, and Metabolism
- Lipid metabolism and disorders
- Diabetes Treatment and Management
- Diet and metabolism studies
- Diabetes Management and Research
- Health Systems, Economic Evaluations, Quality of Life
- Pharmaceutical Economics and Policy
- Antiplatelet Therapy and Cardiovascular Diseases
- Pharmacology and Obesity Treatment
- Diabetes and associated disorders
- Health Promotion and Cardiovascular Prevention
- Adipokines, Inflammation, and Metabolic Diseases
- Metabolism, Diabetes, and Cancer
- Diabetes Management and Education
- Health and Medical Studies
- Cholesterol and Lipid Metabolism
- Obesity, Physical Activity, Diet
- Liver Disease Diagnosis and Treatment
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Atherosclerosis and Cardiovascular Diseases
- Bariatric Surgery and Outcomes
- Metabolism and Genetic Disorders
- Obesity and Health Practices
LMU Klinikum
2016-2025
Ludwig-Maximilians-Universität München
2016-2025
University Hospital Leipzig
2019-2023
Klinik und Poliklinik für Hals-, Nasen-, Ohrenheilkunde
2022
European Atherosclerosis Society
2021
München Klinik
2003-2018
Institut für Urheber- und Medienrecht
2016-2018
University Hospital Münster
2018
Washington University in St. Louis
1990-2015
Sorbonne Université
2015
Guidelines and Expert Consensus documents aim to present management recommendations based on all of the relevant evidence a particular subject in order help physicians select best possible strategies for individual patient, suffering from specific condition, taking into account not only impact outcome, but also risk benefit ratio diagnostic or therapeutic procedure. The ESC guidelines production can be found website†. In brief, appoints experts field carry out comprehensive critical...
Homozygous familial hypercholesterolaemia (HoFH) is a rare life-threatening condition characterized by markedly elevated circulating levels of low-density lipoprotein cholesterol (LDL-C) and accelerated, premature atherosclerotic cardiovascular disease (ACVD). Given recent insights into the heterogeneity genetic defects clinical phenotype HoFH, availability new therapeutic options, this Consensus Panel on Familial Hypercholesterolaemia European Atherosclerosis Society (EAS) critically...
High-fat (HF)-diet rodent models have contributed significantly to the analysis of pathophysiology insulin resistance syndrome, but their phenotype varies distinctly between different studies. Here, we systematically compared metabolic and molecular effects HF with varying fatty acid compositions. Male Wistar rats were fed diets (42% energy; fat sources: HF-L – lard; HF-O olive oil; HF-C coconut fat; HF-F fish oil). Weight, food intake, whole-body tolerance plasma parameters glucose lipid...
This 2022 European Atherosclerosis Society lipoprotein(a) [Lp(a)] consensus statement updates evidence for the role of Lp(a) in atherosclerotic cardiovascular disease (ASCVD) and aortic valve stenosis, provides clinical guidance testing treating elevated levels, considers its inclusion global risk estimation. Epidemiologic genetic studies involving hundreds thousands individuals strongly support a causal continuous association between concentration outcomes different ethnicities; is factor...
Objectives Chemerin is a recently discovered adipokine that regulates adipocyte differentiation and modulates chemotaxis activation of dendritic cells macrophages. Given the convergence macrophage function, chemerin may provide an interesting link between obesity, inflammation atherosclerosis in humans. We sought to examine relationship i) markers inflammation, ii) components metabolic syndrome, iii) coronary atherosclerotic plaque burden morphology. Design Serum levels were determined 303...
Objectives— Pericardial fat as a visceral depot may be involved in the pathogenesis of coronary atherosclerosis. To gain evidence for that concept we sought to investigate relation pericardial volumes risk factors, serum adiponectin levels, inflammatory biomarkers, and quantity morphology Methods Results— Using Dual source CT angiography volume atherosclerosis were assessed simultaneously. Plaques classified calcified, mixed, noncalcified, number affected segments served quantitative score....
Aim To evaluate the effect of alirocumab on frequency standard apheresis treatments [weekly or every 2 weeks (Q2W)] in heterozygous familial hypercholesterolaemia (HeFH). Methods and results ODYSSEY ESCAPE (NCT02326220) was a double-blind study 62 HeFH patients undergoing regular weekly Q2W lipoprotein apheresis. Patients were randomly assigned (2:1, respectively) to receive 150 mg (n = 41) placebo 21) subcutaneously for 18 weeks. From day 1 week 6, rate fixed according patient’s established...
Abstract This 2023 statement updates clinical guidance for homozygous familial hypercholesterolaemia (HoFH), explains the genetic complexity, and provides pragmatic recommendations to address inequities in HoFH care worldwide. Key strengths include updated criteria diagnosis of recommendation prioritize phenotypic features over genotype. Thus, a low-density lipoprotein cholesterol (LDL-C) >10 mmol/L (>400 mg/dL) is suggestive warrants further evaluation. The also state-of-the...
To provide an update on glycaemic control in European patients with type 2 diabetes based data from the nine-country, cross-sectional PANORAMA study (NCT00916513).Post-hoc analysis to report number of achieving/not achieving goal (HbA(1c) <7%).Patients were randomly or consecutively selected physician practices nine countries. Eligible aged ≥40 years, diagnosed >1 year prior entry, and had available medical record year.All collected at a single visit, including HbA1c measurement using common...
Aim of the present Consensus Statement is to provide a comprehensive and up to-date document on pathophysiology, atherogenicity clinical significance low density liproproteins (LDL) subclasses. We sub-divided our statement in 2 sections. section I discusses measurement issues, while II focused effects drug lifestyle modifications. Suggestions for future research field are highlighted at end II. Each includes Conclusions.
Abstract The gut microbiota has been linked to metabolic diseases. However, information on the microbiome of young adults at risk for type 2 diabetes (T2D) is lacking. aim this cross-sectional analysis was investigate whether insulin resistant women with previous gestational (pGDM), a high group T2D, differ in their stool from after normoglycemic pregnancy (controls). Bacterial communities were analyzed by high-throughput 16S rRNA gene sequencing using fecal samples 42 pGDM and 35 control...