A5009401408- Diabetes and associated disorders
- Pancreatic function and diabetes
- Diabetes Management and Research
- Xenotransplantation and immune response
- Diet and metabolism studies
- Metabolism, Diabetes, and Cancer
- Hormonal Regulation and Hypertension
- Immunotherapy and Immune Responses
- Diabetes Treatment and Management
- Gestational Diabetes Research and Management
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Adrenal Hormones and Disorders
- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Cancer Immunotherapy and Biomarkers
- Diabetes Management and Education
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Metabolomics and Mass Spectrometry Studies
- Bariatric Surgery and Outcomes
- Birth, Development, and Health
- Liver Disease Diagnosis and Treatment
- Thyroid Disorders and Treatments
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Cardiovascular Health and Disease Prevention
Ludwig-Maximilians-Universität München
2016-2025
LMU Klinikum
2016-2025
Heinrich Heine University Düsseldorf
2009-2025
Helmholtz Zentrum München
2014-2025
Deutsches Diabetes-Zentrum e.V.
2009-2025
German Center for Diabetes Research
2015-2025
Phoenix Contact (Germany)
2024
University Hospital Heidelberg
2023
Heidelberg University
1993-2023
Klinikum rechts der Isar
2022
Background Information regarding the variability of metabolite levels over time in an individual is required to estimate reproducibility measurements. In intervention studies, it critical appropriately judge changes that are elicited by any kind intervention. The pre-analytic phase (collection, transport and sample processing) a particularly important component data quality multi-center studies. Methods Reliability metabolites (within-and between-person variance, intraclass correlation...
Islet transplantation is a potential treatment for type 1 diabetes, but the shortage of donor organs limits its routine application. As animals, we generated transgenic pigs expressing LEA29Y, high-affinity variant T-cell costimulation inhibitor CTLA-4Ig, under control porcine insulin gene promoter. Neonatal islet cell clusters (ICCs) from INSLEA29Y (LEA-tg) and wild-type controls were transplanted into streptozotocin-induced hyperglycemic NOD-scid IL2Rγ(null) mice. Cloned LEA-tg are healthy...
Abstract The gut microbiota has been linked to metabolic diseases. However, information on the microbiome of young adults at risk for type 2 diabetes (T2D) is lacking. aim this cross-sectional analysis was investigate whether insulin resistant women with previous gestational (pGDM), a high group T2D, differ in their stool from after normoglycemic pregnancy (controls). Bacterial communities were analyzed by high-throughput 16S rRNA gene sequencing using fecal samples 42 pGDM and 35 control...
Diabetes imposes a huge social and economic impact on nations. However, information the costs of treating managing diabetes in developing countries is limited. The aim this study was to estimate healthcare use expenditure for Bangladesh.We conducted matched case-control between January July 2014 among 591 adults with diagnosed mellitus (DMs) age-matched, sex-matched residence-matched persons without (non-DMs). We recruited DMs from consecutive patients non-DMs accompanying Bangladesh...
Lifestyle intervention (LI) can prevent type 2 diabetes, but response to LI varies depending on risk subphenotypes. We tested whether individuals with prediabetes low (LR) benefit from conventional and high (HR) an intensification of in a multicenter randomized controlled over 12 months years’ follow-up. A total 1,105 based American Diabetes Association glucose criteria were stratified into HR or LR phenotype previously described thresholds insulin secretion, sensitivity, liver fat content....
OBJECTIVE Progression of prediabetes to type 2 diabetes has been associated with β-cell dysfunction, whereas its remission normoglycemia related improvement insulin sensitivity. To understand the mechanisms and identify potential biomarkers trajectories, we compared proteomics metabolomics profile people progressing or reversing within 1 year. RESEARCH DESIGN AND METHODS The fasting plasma concentrations 1,389 proteins fasting, 30-min, 120-min post–oral glucose tolerance test (OGTT) 152...
To estimate the impact of type 1 diabetes during pregnancy on transgenerational genetically caused and/or fuel-mediated amplification types and 2 to elevated amniotic fluid insulin levels.A total 75 white offspring diabetic mothers 49 control subjects similar age pubertal stage were examined at 5-15 years age. All had an oral glucose tolerance test. Glucose, insulin, C-peptide measured 0, 30, 60, 120 min after loading. Lipids autoimmune antibodies in fasting plasma.Of offspring, 4 (5.3%)...
Abstract The antitumor effect of IFN-α is mediated by the activation CTLs, NK cells, and generation highly potent Ag-presenting dendritic cells (IFN-DCs). In this study, we show that IFN-DCs generated in vitro from monocytes express CD56 on their surface, a marker which has been thought to be specific for cells. FACS analyses CD56+ CD56− showed nearly identical pattern most classical DC markers. Importantly, however, only exhibited cytolytic activity up 24% could almost completely blocked...
The prevalence of primary aldosteronism in unselected hypertensive patients is currently unknown. We investigated the frequency positive screening results for based on aldosterone-to-renin ratio (ARR) subjects aged 30–79 years from two German epidemiological studies. further examined with resistant hypertension or stage III and assessed possible disparities between untreated treated subjects. Data were obtained first follow-ups population-based Study Health Pomerania (SHIP; n=1392)...
Aldosterone excess in the context of primary aldosteronism (PA) has been associated with impaired glucose tolerance and diabetes mellitus. We retrospectively assessed prevalence mellitus patients from German Conn's Register compared data those hypertensive subjects a population-based survey. In case-control study, we have 638 PA registry who were treated 6 centers 897 control F3 survey Cooperative Health Research Region Augsburg (KORA). The samples matched for age, sex, blood pressure 1:1...
To explore the association between knowledge on diabetes and glycemic control among patients with type 2 in Bangladesh.A cross-sectional study was conducted 515 attending a tertiary hospital Dhaka, Bangladesh. Trained interviewers were used to collect data socioeconomic status, time since onset of diabetes, co-morbidities, anthropometric measurements, blood tests, perceptions about causes, management, complications through face based structured questionnaire. Diabetes reported using...
Primary aldosteronism (PA) represents the most frequent cause of secondary arterial hypertension. Conflicting data have been published regarding effect aldosterone excess on glucose metabolism. Our aim was to analyze insulin sensitivity and β-cell function in a cohort PA patients. Prospective follow-up investigations were performed subgroup patients before after adrenalectomy assess metabolic outcome. Oral tolerance test, combined intravenous hyperinsulinemic-euglycemic clamp arginine test...
Multipotent mesenchymal stromal cells (MSCs) are bone marrow-derived of nonhematopoietic origin with immunoregulatory properties. Although some functions MSCs have been identified, there still features that not explained thus far. The aim the present study was to identify novel factors involved in MSC-mediated inhibition T-cell proliferation. We here demonstrate surface molecule CD39 is coexpressed concert CD73 on murine catalyzing generation adenosine, which can directly act activated T via...