A5016239812- Diabetes and associated disorders
- Diabetes Management and Research
- Pancreatic function and diabetes
- Diabetes Treatment and Management
- Metabolism, Diabetes, and Cancer
- Diet and metabolism studies
- Adipose Tissue and Metabolism
- Cardiovascular Function and Risk Factors
- Diabetes, Cardiovascular Risks, and Lipoproteins
- T-cell and B-cell Immunology
- Adipokines, Inflammation, and Metabolic Diseases
- Diet, Metabolism, and Disease
- Liver Disease Diagnosis and Treatment
- Cardiovascular Disease and Adiposity
- Immune Cell Function and Interaction
- Regulation of Appetite and Obesity
- Pharmacology and Obesity Treatment
- COVID-19 Clinical Research Studies
- Obesity, Physical Activity, Diet
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Peroxisome Proliferator-Activated Receptors
- Adrenal Hormones and Disorders
- Retinal Diseases and Treatments
- Chronic Kidney Disease and Diabetes
- Diabetes Management and Education
Sapienza University of Rome
2016-2025
Policlinico Umberto I
1992-2022
University of Foggia
2020
Associazione Medici Diabetologi
2019
University of Padua
2017
Ospedale Santa Maria Goretti
2015-2016
Foro Italico University of Rome
2015
Agostino Gemelli University Polyclinic
2007
Campus Bio Medico University Hospital
2006
Bambino Gesù Children's Hospital
2004-2005
Susceptibility to autoimmune insulin-dependent (type 1) diabetes mellitus is determined by a combination of environmental and genetic factors, which include variation in MHC genes on chromosome 6p21 (IDDM1) the insulin gene 11p15 (IDDM2). However, linkage IDDM1 IDDM2 cannot explain clustering type 1 families, role for other inferred. In present report we describe association CTLA-4 (cytotoxic T lymphocyte associated-4) 2q33 (designated IDDM12). strong candidate cell-mediated disease because...
A novel RNA betacoronavirus causing coronavirus disease 2019 (Covid-19) has now been declared pandemic by WHO. Guo et al published the first report of biochemical features in patients with diabetes and further risk that this can determine to progression Covid-19. Among different cytokines found significantly higher compared those without, Interleukin-6 (IL-6), which is already increased conditions chronic inflammation, may play a more deleterious role Covid-19 infection. Targeting...
Specific autoantibodies characterize type 1 diabetes in childhood but are also found adult-onset diabetes, even when initially non-insulin requiring, e.g., with latent autoimmune (LADA). We aimed to diabetes.
A substantial proportion of patients with adult-onset diabetes share features both type 1 (T1D) and 2 (T2D). These individuals, at diagnosis, clinically resemble T2D by not requiring insulin treatment, yet they have immunogenetic markers associated T1D. Such a slowly evolving form autoimmune diabetes, described as latent adults (LADA), accounts for 2–12% all though show considerable variability according to their demographics mode ascertainment. While therapeutic strategies aim metabolic...
The aim of the present study was to define heterogeneity adult-onset autoimmune diabetes based on characterization GAD antibodies (GADAs).Patients enrolled in a nationwide survey, Non Insulin Requiring Autoimmune Diabetes (NIRAD) Study, have been screened for GADAs and IA-2 (IA-2As) further characterized GADA titer, thyroid peroxidase (TPO), HLA DRB1-DQB1 polymorphisms.Of 4,250 consecutive type 2 diabetic patients, 4.5% had either and/or IA-2As. Patients with showed clinical phenotype...
The melanocortin-4 receptor (MC4R) gene pathogenic mutations are the most prevalent forms of monogenic obesity, responsible for ∼2% obesity cases, but its role in common is still elusive. We analyzed contribution non-synonymous V103I (rs2229616, c.307G > A) and I251L (no rs, c.751A C) to 16 797 individuals European origin from nine independent case–control, population-based familial cohorts. observed a consistent negative association variant (prevalence ranging 0.41–1.21%) with both...
OBJECTIVE Zinc transporter 8 (ZnT8) is an islet β-cell secretory granule membrane protein recently identified as autoantibody antigen in type 1 diabetes. The aim of this study was to determine the prevalence and role antibodies ZnT8 (ZnT8As) adult-onset RESEARCH DESIGN AND METHODS ZnT8As were measured by a radioimmunoprecipitation assay using recombinant COOH-terminal or NH2-terminal proteins 193 patients with autoimmune diabetes having either GAD (GADAs) IA-2 (IA-2As) 1,056...
This study evaluates the relation of a Mediterranean dietary pattern and its individual components with cardiovascular risk factors profile, plasma glucose body mass index (BMI) in people type 2 diabetes. We studied 2568 participants at 57 diabetes clinics. Diet was assessed EPIC (European Prospective Investigation into Cancer Nutrition) questionnaire, adherence to diet evaluated relative score (rMED). A high compared low associated better quality greater nutritional recommendations for...
Abstract Background Cardiometabolic disorders may worsen Covid-19 outcomes. We investigated features and outcomes for patients with or without diabetes, cardiometabolic multimorbidity. Methods collected compared data retrospectively from hospitalized multimorbidity (defined as ≥ two of three risk factors hypertension dyslipidaemia). Multivariate logistic regression was used to assess the primary composite outcome (any mechanical ventilation, admission an intensive care unit [ICU] death) in...
Previous genome-wide mapping studies have provided suggestive linkage evidence for several novel susceptibility loci responsible insulin-dependent diabetes mellitus (IDDM); however, the was not sufficient to confirm existence of these genes. We analyzed 265 Caucasian families with IDDM and report first that meets standard confirmed three loci. The maximum LOD scores (MLS) were 3.9, 4.5 3.6 in our data set, 5.0, 4.6 5.0 combined non-overlapping from literature, IDDM4 on chromosome 11q13,...
The purpose of this study was to estimate whether prevalence metabolic syndrome in adult European diabetic patients is associated with type diabetes.A consecutive series attending hospital-based diabetes clinics were assessed for the frequency and compared population-based control subjects as part Action LADA study. In total, 2,011 (aged 30-70 years) studied, including 1,247 recent-onset 2 without glutamic acid decarboxylase autoantibodies (GADAs), 117 non-insulin-requiring GADAs who had not...