A5039743691- Bone health and treatments
- Metabolism and Genetic Disorders
- Bone Metabolism and Diseases
- Dermatological and Skeletal Disorders
- Connective tissue disorders research
- Wnt/β-catenin signaling in development and cancer
- Skin and Cellular Biology Research
- Cardiac Arrhythmias and Treatments
- Mitochondrial Function and Pathology
- Genomic variations and chromosomal abnormalities
- Congenital Heart Disease Studies
- Bone health and osteoporosis research
- Biochemical and Molecular Research
- Genetic Neurodegenerative Diseases
- Pulmonary Hypertension Research and Treatments
- Glycogen Storage Diseases and Myoclonus
- Liver Disease Diagnosis and Treatment
- Genetics and Neurodevelopmental Disorders
- Genetic factors in colorectal cancer
- Neonatal Health and Biochemistry
- Bone Tumor Diagnosis and Treatments
- Medical Imaging and Pathology Studies
- Vasculitis and related conditions
- Neurological and metabolic disorders
- Adrenal Hormones and Disorders
University of Antwerp
2015-2024
Antwerp University Hospital
2015-2024
Aalborg University
2019
Charité - Universitätsmedizin Berlin
2009
Leiden University Medical Center
2009
Academic Center for Dentistry Amsterdam
2009
University Hospital Ulm
2009
Universität Ulm
2009
National Medical Research Center of Dentistry and Maxillofacial Surgery
2009
Cliniques Universitaires Saint-Luc
2007
Human hereditary cerebral hemorrhage with amyloidosis of the Dutch type (HCHWA-D), an autosomal dominant form amyloid angiopathy (CAA), is characterized by extensive deposition in small leptomeningeal arteries and cortical arterioles, which lead to early death those afflicted their fifth or sixth decade. Immunohistochemical biochemical studies have indicated that subunit HCHWA-D antigenically related homologous sequence β protein isolated from brains patients Alzheimer's disease Down...
Humans lacking sclerostin display progressive bone overgrowth due to increased formation. Although it is well established that an osteocyte-secreted formation inhibitor, the underlying molecular mechanisms are not fully elucidated. We identified in tandem affinity purification proteomics screens LRP4 (low density lipoprotein-related protein 4) as a interaction partner. Biochemical assays with recombinant proteins confirmed direct. Interestingly, vitro overexpression and RNAi-mediated...
The low-density-lipoprotein receptor-related protein 5 (LRP5), a coreceptor in the canonical Wnt signaling pathway, has been implicated human disorders of low and high bone mass. Loss-of-function mutations cause autosomal recessive osteoporosis-pseudoglioma syndrome, heterozygous missense families segregating dominant mass (HBM) phenotypes have identified. We expressed seven different HBM-LRP5 to delineate mechanism by which they alter signaling. None caused activation receptor absence...
This study illustrates that Plekhm1 is an essential protein for bone resorption, as loss-of-function mutations were found to underlie the osteopetrotic phenotype of incisors absent rat well intermediate type human osteopetrosis. Electron and confocal microscopic analysis demonstrated monocytes from a patient homozygous mutation differentiated into osteoclasts normally, but when cultured on dentine discs, failed form ruffled borders showed little evidence resorption. The presence both RUN...