Nadine Van Roy
A5015213142- Neuroblastoma Research and Treatments
- Cancer Genomics and Diagnostics
- Genomic variations and chromosomal abnormalities
- Acute Myeloid Leukemia Research
- Cancer, Hypoxia, and Metabolism
- Acute Lymphoblastic Leukemia research
- RNA modifications and cancer
- Lung Cancer Research Studies
- Sarcoma Diagnosis and Treatment
- Microtubule and mitosis dynamics
- Chronic Lymphocytic Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Chromosomal and Genetic Variations
- Epigenetics and DNA Methylation
- Genetic factors in colorectal cancer
- Cancer-related molecular mechanisms research
- Cancer therapeutics and mechanisms
- Glioma Diagnosis and Treatment
- Prenatal Screening and Diagnostics
- Virus-based gene therapy research
- Protein Degradation and Inhibitors
- Neuroendocrine Tumor Research Advances
- Lymphoma Diagnosis and Treatment
- Chromatin Remodeling and Cancer
- MicroRNA in disease regulation
Ghent University Hospital
2016-2025
Cancer Research Institute Ghent
2015-2024
Ghent University
2014-2024
VIB-UGent Center for Medical Biotechnology
2024
AZ Sint-Jan
2007-2023
Cancer Research Institute
2023
Rode Kruis-Vlaanderen
2021
European Organisation for Research and Treatment of Cancer
2015
Institute of Pathology and Genetics
2014
St Anna Children's Hospital
2003-2011
Gain of genetic material from chromosome arm 17q (gain segment 17q21–qter) is the most frequent cytogenetic abnormality neuroblastoma cells. This gain has been associated with advanced disease, patients who are ≥1 year old, deletion 1p, and amplification N-myc oncogene, all which predict an adverse outcome. We investigated these associations evaluated prognostic importance status 17.
The HEK293 human cell lineage is widely used in biology and biotechnology. Here we use whole-genome resequencing of six 293 lines to study the dynamics this aneuploid genome response manipulations generate common derivatives, such as transformation stable clone generation (293T); suspension growth adaptation (293S); cytotoxic lectin selection (293SG). Remarkably, observe that copy number alteration detection could identify genomic region enabled survival under selective conditions (i.c....
Neurofibromatosis type 1 (NF1) is one of the most common autosomal dominant disorders and caused by mutations in NF1 gene. Mutation detection complex due to large size gene, presence pseudogenes great variety possible lesions. Although there no evidence for locus heterogeneity NF1, mutation rates rarely exceed 50%. We studied 67 unrelated patients fulfilling NIH diagnostic criteria, 29 familial 38 sporadic cases, using a cascade complementary techniques. performed protein truncation test...
Purpose Neuroblastoma is a genetically heterogeneous pediatric tumor with remarkably variable clinical behavior ranging from widely disseminated disease to spontaneous regression. In this study, we aimed for comprehensive genetic subgroup discovery and assessment of independent prognostic markers based on genome-wide aberrations detected by comparative genomic hybridization (CGH). Materials Methods Published CGH data 231 primary untreated neuroblastomas were converted digitized format...
Purpose: Neuroblastoma (NB) is a heterogeneous disease characterized by distinct clinical features and the presence of typical copy-number alterations (CNAs). Given strong association these CNA profiles with prognosis, analysis profile at diagnosis mandatory. Therefore, we tested whether circulating cell-free DNA (cfDNA) present in plasma samples patients NB could offer valuable alternative to primary tumor for profiling.Experimental Design: In 37 NB, cfDNA using shallow whole genome...
The classification of the until recently poorly explored group atypical adipocytic neoplasms with spindle cell features, for which term lipomatous tumor (ASLT) has been proposed, remains challenging. Recent studies have proposed ASLT as a unique entity (in at least significant subset cases) specific genetic background, namely deletions/losses 13q14, including RB1 and its flanking genes RCBTB2, DLEU1, ITM2B. Similar aberrations reported in pleomorphic liposarcomas (PLSs). This prompted us to...
Double minutes (dmin), homogeneously staining regions, and ring chromosomes are vehicles of gene amplification in cancer. The underlying mechanism leading to their formation as well structure function acute myeloid leukemia (AML) remain mysterious. We combined a range high-resolution genomic methods investigate the architecture expression pattern amplicons involving chromosome band 8q24 23 cases AML (AML-amp). This revealed that different MYC-dmin architectures can coexist within same...
Abstract We report on the finding of a t(1;17) in two primary neuroblastomas. Subsequent fluorescence situ hybridization (FISH) analysis revealed presence 1; 17 transfocations four out nine neuroblastoma cell lines. The chromosome 1 short arm breakpoints were determined using region‐specific probes. FISH screening also demonstrated or confirmed 11;17 translocations three lines and other rearrangements those that did not carry t(1; 17) t(11; 17). Our data extend previous cytogenetic findings...
Partial and complete genome duplications occurred during evolution resulted in the creation of new genes gene families. We identified a novel intricate human family located primarily regions segmental on chromosome 1. named it NBPF, for neuroblastoma breakpoint family, because one its members is disrupted by chromosomal translocation patient. The NBPF have repetitive structure with high intragenic intergenic sequence similarity both coding noncoding regions. These similarities might expose...
Double minutes (dmin)-circular, extra-chromosomal amplifications of specific acentric DNA fragments-are relatively frequent in malignant disorders, particularly solid tumors. In acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS), dmin are observed approximately 1% the cases. Most them consist an amplified segment from chromosome band 8q24, always including MYC gene. Besides this information, little is known about their internal structure. We have characterized detail genomic...
Comparative genomic hybridization (CGH) analysis was performed on 36 neuroblastomas of both low and high stage disease. This study significantly increases the number neuroblastoma tumors studied by CGH. Analysis larger series is particularly important in view different clinical subgroups that are recognized for this tumor. The present data a comparison with all published CGH provide further insights into genetic heterogeneity neuroblastoma. Stage 1, 2, 4S showed predominantly whole...