A5013269390- T-cell and B-cell Immunology
- Proteoglycans and glycosaminoglycans research
- Immune Cell Function and Interaction
- Chemokine receptors and signaling
- Ubiquitin and proteasome pathways
- Immunotherapy and Immune Responses
- Glycosylation and Glycoproteins Research
- Immunodeficiency and Autoimmune Disorders
- Acute Myeloid Leukemia Research
- Lung Cancer Diagnosis and Treatment
- Peptidase Inhibition and Analysis
- Eosinophilic Disorders and Syndromes
- Vascular Malformations and Hemangiomas
- Radiomics and Machine Learning in Medical Imaging
- Fibroblast Growth Factor Research
- Gastrointestinal disorders and treatments
- Cytokine Signaling Pathways and Interactions
- Renal Diseases and Glomerulopathies
- Vascular Tumors and Angiosarcomas
- Lung Cancer Treatments and Mutations
- Protein Degradation and Inhibitors
- Oral and Maxillofacial Pathology
- Prostate Cancer Treatment and Research
- Soft tissue tumor case studies
- Protein Kinase Regulation and GTPase Signaling
Rambam Health Care Campus
2016-2025
Technion – Israel Institute of Technology
2015-2025
Weizmann Institute of Science
2023
Rappaport Family Institute for Research in the Medical Sciences
2006-2016
A single G protein-coupled receptor (GPCR) can activate multiple signaling cascades based on the binding of different ligands. The biological relevance this feature in immune regulation has not been evaluated. chemokine-binding GPCR CXCR3 is preferentially expressed CD4+ T cells, and canonically binds 3 structurally related chemokines: CXCL9, CXCL10, CXCL11. Here we have shown that CXCL10/CXCR3 interactions drive effector Th1 polarization via STAT1, STAT4, STAT5 phosphorylation, while...
Experimental autoimmune encephalomyelitis (EAE) is a T cell–mediated disease of the central nervous system induced by antigen-specific effector Th17 and Th1 cells. We show that key chemokine, CXCL12 (stromal cell–derived factor 1α), redirects polarization cells into CD4+CD25−Foxp3−interleukin (IL) 10high regulatory in CXCR4-dependent manner, doing so acts as mediator restraining inflammatory process. In an attempt to explore therapeutic implication these findings, we have generated...
<sup>68</sup>Ga-labeled prostate-specific membrane antigen (PSMA), a PET tracer that was recently introduced for the imaging of prostate cancer, may accumulate in other solid tumors, including hepatocellular carcinoma (HCC). The aim this study to assess potential role <sup>68</sup>Ga-PSMA PET/CT HCC. <b>Methods:</b> Included prospective pilot were 7 patients who had HCC with 41 liver lesions: 37 suspected malignant lesions (tumor lesions) and 4 regenerative nodules. For each lesion, uptake...
IL-27 is a recently defined family member of the long-chain four-helix bundle cytokines, which consists EBI3, an IL-12p40-related protein, and p28, IL-12p35-related polypeptide. The role in regulation inflammatory autoimmune diseases has never been studied. current study uses DNA vaccination technology, highly specific Abs to p28 subunit that were generated by this delineate its adjuvant-induced arthritis Lewis rats. Neutralizing vivo function targeted vaccines against produced protected...
Ubiquitylation regulates signaling pathways critical for cancer development and, in many cases, targets proteins degradation. Here, we report that ubiquitylation by RNF4 stabilizes otherwise short-lived oncogenic transcription factors, including β-catenin, Myc, c-Jun, and the Notch intracellular-domain (N-ICD) protein. enhances transcriptional activity of these as well Wnt- Notch-dependent gene expression. While is a SUMO-targeted ubiquitin ligase, protein stabilization requires substrate's...
Abstract Mitochondrial protein synthesis requires charging mt-tRNAs with their cognate amino acids by mitochondrial aminoacyl-tRNA synthetases, the exception of glutaminyl mt-tRNA (mt-tRNA Gln ). is indirectly charged a transamidation reaction involving GatCAB amidotransferase complex. Defects machinery cause broad spectrum disorders, often fatal outcome. Here, we describe nine patients from five families genetic defects in complex subunit, including QRSL1 , GATB and GATC each showing lethal...
Mammalian cells express a single functional heparanase, an endoglycosidase that cleaves heparan sulfate and thereby promotes tumor metastasis, angiogenesis, inflammation. Malignant mesothelioma is highly aggressive has poor prognosis because of the lack markers for early diagnosis resistance to conventional therapies. The purpose this study was elucidate mode action biological significance heparanase in test efficacy inhibitors treatment malignancy. involvement investigated by applying mouse...
Cytokine storm refers to the dysregulated production of inflammatory mediators leading hyperinflammation. They are often detrimental, and worsen severity COVID-19 other infectious or diseases. Cannabinoids known have anti-inflammatory effects but their possible therapeutic value on cytokine storms has not been fully elucidated. In vivo ex studies were carried out investigate high-THC high-CBD extracts in immune cells. Significant differences between observed. Subsequent experiments focusing...
IL-27 is a recently defined family member of the long-chain, four-helix bundle cytokines, which consist EBI3, an IL-12p40-related protein, and p28, IL-12p35-related polypeptide. The role in regulation experimental autoimmune encephalomyelitis has never been studied. We show this study that neutralizing vivo function by Abs against p28 rapidly suppressed ongoing long-lasting disease C57BL/6 mice. These were then used to determine mechanistic basis suppression. involved not only polarization...
The potential role of prostate-specific membrane antigen (PSMA) PET/CT in non–prostate cancer tumors has shown promising results. We examined the performance dynamic <sup>68</sup>Ga-PSMA-11 (DPSMA) for evaluation localized renal mass. <b>Methods:</b> A prospective case series patients with a newly diagnosed mass who were referred surgery was examined. DPSMA performed standardized manner before surgery. final surgical histology served as standard reference. PSMA expression tumor vasculature...
Painful lumbar radiculopathy is a neuropathic pain condition, commonly attributed to nerve root inflammation/compression by disc herniation. The present exploratory study searched for associations between intensity and inflammatory markers, herniated size, infection, psychological factors modulation in patients with confirmed painful scheduled spine surgery.Prior surgery, 53 underwent the following evaluation: measured on 0-10 numeric rating scale (NRS) Short-Form McGill Pain Questionnaire;...
The combination of ependymoma and gliosarcoma elements in the same tumor is extremely rare, molecular characteristics these entities are not clear. Here, we present a rare aggressive brain 12-year-old boy harboring ZFTA::RELA gene fusion, characteristic feature supratentorial ependymomas. On other hand, histopathological, molecular, methylation profiles were compatible with diagnosis mesenchymal type, IDH wild-type glioblastoma multiforme (GBM). Additional somatic alterations provide...
Objective This study aimed to introduce and evaluate a novel software-based system, BioTrace, designed for real-time monitoring of thermal ablation tissue damage during image-guided radiofrequency hepatocellular carcinoma (HCC). Methods BioTrace utilizes proprietary algorithm analyze the temporo-spatial behavior gas bubble activity ablation, as seen in conventional B-mode ultrasound imaging. Its predictive accuracy was assessed by comparing zones it predicted with those annotated...
Alveolar active sodium transport is essential for clearing edema from airspaces, in a process known as alveolar fluid clearance (AFC). Although it has been reported that atrial natriuretic peptide (ANP) attenuates AFC, little about the underlying molecular effects of peptides (NPs). Therefore, we examined contribution NPs to AFC and their mediators transport. By using isolated liquid-filled lungs model, investigated on AFC. The expression NPs, Na+, K+-ATPase, Na+ channels was assessed...
We have recently demonstrated that patients suffering from chronic autoimmune diseases develop an autoantibody response against key mediators participate in the initiation and progression of these diseases. In this paper, we show with type 1 diabetes mellitus (T1DM), but not those several other inflammatory diseases, display a selective titer to single CC chemokine named CCL3. From diagnostic point could be used as biomarker for diagnosis T1DM, disease is currently diagnosed by...
Loss of the complement inhibitor CD55 leads to a syndrome early-onset protein-losing enteropathy (PLE), associated with intestinal lymphangiectasia and susceptibility large-vein thrombosis. The in vitro short-term treatment benefits eculizumab (C5-inhibitor) therapy for CD55-deficiency have been previously demonstrated. Here we present 18-months outcomes 3 patients sustained therapeutic response.Three received off-label treatment. Clinical laboratory included frequency consistency bowl...