A5047542922- Acute Myeloid Leukemia Research
- Blood disorders and treatments
- Chronic Myeloid Leukemia Treatments
- Immunodeficiency and Autoimmune Disorders
- Genomic variations and chromosomal abnormalities
- Chronic Lymphocytic Leukemia Research
- Acute Lymphoblastic Leukemia research
- Prenatal Screening and Diagnostics
- Chromosomal and Genetic Variations
- Cancer Genomics and Diagnostics
- Pneumocystis jirovecii pneumonia detection and treatment
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Neonatal Health and Biochemistry
- Renal and related cancers
- Erythrocyte Function and Pathophysiology
- Blood groups and transfusion
- Hematopoietic Stem Cell Transplantation
- Lymphoma Diagnosis and Treatment
- Ear and Head Tumors
- Molecular Biology Techniques and Applications
- Head and Neck Surgical Oncology
- Cancer-related gene regulation
- Genomics and Rare Diseases
- Cancer-related molecular mechanisms research
- Cancer-related Molecular Pathways
University of Insubria
2014-2023
University of Modena and Reggio Emilia
2019
University of Parma
2015-2017
University of Pavia
1990-2008
Sapienza University of Rome
1985
Lund University
1985
Policlinico San Matteo Fondazione
1981-1984
Istituto di Genetica Molecolare
1979-1983
Immunologic studies were performed in 83 patients with Down's Syndrome (DS) ages ranging from a few months to 30 years and 76 karyotypically normal age-matched controls. The results show that both thymus-dependent independent functions impaired DS characteristic age sequence. Serum immunoglobulin levels children less then 5 old; after 6 of definite hyperglobulinemia the IgG IgA type was observed. A slight decrease IgM observed between 16 25 age. In subjects lymphocyte phytohemagglutinin...
Abstract The HeLa cell line is one of the most popular lines in biomedical research, despite its well-known chromosomal instability. We compared genomic and transcriptomic profiles 4 different batches showed that gain loss material varies widely between batches, drastically affecting basal gene expression. Moreover, pathways were activated response to a hypoxic stimulus. Our study emphasizes large variability among point same experiment performed with can lead distinct conclusions...
Holistic interpretation of data related to combinatory treatments five ENMs in zucchini.
Summary An investigation of 22 new patients with Shwachman‐Diamond syndrome (SDS) and the follow‐up 14 previously reported cases showed that (i) clonal chromosome changes chromosomes 7 20 were present in bone marrow (BM) 16 out 36 cases, but if non‐clonal taken into account, frequency anomalies affecting these was 20/36: a specific SDS karyotype instability thus confirmed; (ii) recurrent isochromosome i(7)(q10) did not include short arm material, whereas it retained two arrays D7Z1 alphoid...
Abstract PDGFRB, a transmembrane tyrosine kinase receptor for plateletderived growth factor, is constitutively activated by gene fusion with different partners in myeloproliferative/myelodysplastic disorders peculiar clinical characteristics. Six alternative partner genes have been described thus far. In this study, we report the molecular cloning of novel translocation t(5;17)(q33;p11.2) case juvenile myelomonocytic leukemia. The was identified as HCMOGT-1 using 5′-rapid amplification cDNA...
Reciprocal translocation t(9;22) is central to the pathogenesis of chronic myeloid leukemia. Some authors have suggested that Alu repeats facilitate this process, but supporting analyses been sparse and often anecdotal. The purpose study was analyze local structure translocations assess relevance interspersed repeat elements at breakpoints. Collected data further compared with current models DNA recombination, in particular single-strand annealing (SSA) nonhomologous end joining (NHEJ)...
Three patients, with constitutional trisomy 8 mosaicism (CT8M), who developed a malignancy are reported. The diagnoses were refractory anaemia, acute lymphoblastic leukaemia, and idiopathic myelofibrosis. In the child CT8M was diagnosed at birth due to severe dysmorphisms malformations; other two patients showed milder phenotype, only after finding of in neoplastic cells. review eight similar, previously reported cases clinical, cytogenetic, molecular studies performed our led us make...
Abstract Background The results of cytogenetic investigations on unbalanced chromosome anomalies, both constitutional and acquired, were largely improved by comparative genomic hybridization microarray (a-CGH), but in mosaicism the ability a-CGH to reliably detect imbalances is not yet well established. This problem sensitivity even more relevant acquired neoplastic diseases, where cells carrying coexist with normal cells, particular when proportion abnormal may be low. We constructed a...
Imatinib mesylate (IM) is the first line therapy against Chronic Myeloid Leukemia, effectively prolonging overall survival. Because discontinuation of treatment associated with relapse, IM required indefinitely to maintain operational cure. To assess minimal residual disease, cytogenetic analysis insensitive in a high background normal lymphocytes. The qRT-PCR provides highly sensitive detection BCR-ABL1 transcripts, but mRNA levels are not directly related number leukemic cells, and...
The use of cadmium sulphide quantum dots (CdS QDs) is increasing, particularly in the electronics industry. Their size (1–10 nm diameter) is, however, such that they can be taken up by living cells. Here, a bakers’ yeast (Saccharomyces cerevisiae) deletion mutant collection has been exploited to provide high-throughput means revealing genetic basis for tolerance/susceptibility CdS QD exposure. 112 genes, some associated with abiotic stress response, various metabolic processes, mitochondrial...
Abstract The growing ability of high‐performance consumer electronics is fostering innovation in prototyping and research. Although the Raspberry Pi single‐board computer (SBC) widely used across various fields, including diagnostics, applications involving UV‐based reading remain underexplored. In this study, a simple, low‐cost (less than 100 euros), portable device for UV–vis measurements based on presented. system integrates AS7341 multi‐channel multispectral digital sensor, offering...
Abstract An investigation of 14 patients with Shwachman syndrome (SS), using standard and molecular cytogenetic methods genetic techniques, showed that (1) the i(7)(q10) is not, or not always, an isochromosome but may arise from a more complex mechanism, retaining part short arm; (2) has no preferential parental origin; (3) clonal chromosome changes, such as 7 anomalies del(20)(q11), be present in bone marrow (BM) for long time without progressing to myelodysplastic (MDS)/acute myeloid...