A5006456619- Obstructive Sleep Apnea Research
- Voice and Speech Disorders
- Medical Imaging and Pathology Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Neuroscience of respiration and sleep
- Transplantation: Methods and Outcomes
- Lung Cancer Diagnosis and Treatment
- Tracheal and airway disorders
- Sleep and Wakefulness Research
- Pleural and Pulmonary Diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory viral infections research
- Dysphagia Assessment and Management
- Respiratory and Cough-Related Research
- Sarcoidosis and Beryllium Toxicity Research
- Pneumonia and Respiratory Infections
- Respiratory Support and Mechanisms
- Radiomics and Machine Learning in Medical Imaging
- Venous Thromboembolism Diagnosis and Management
- Pediatric health and respiratory diseases
- Asthma and respiratory diseases
- Vascular Tumors and Angiosarcomas
- Long-Term Effects of COVID-19
- Congenital Diaphragmatic Hernia Studies
- Airway Management and Intubation Techniques
Rambam Health Care Campus
2008-2025
Technion – Israel Institute of Technology
1978-2025
St. Luke's University Health Network
2019-2021
Temple University Hospital
2019-2021
Temple University
2017-2020
Pulmonary and Critical Care Associates
2020
Bnai Zion Medical Center
2010-2019
Previous feasibility studies have shown that electrical stimulation of the hypoglossal nerve can improve obstructive sleep apnea (OSA). The current study examined safety and preliminary effectiveness a second generation device, Upper Airway Stimulation (UAS) system, identified baseline predictors for therapy success. Two consecutive open prospective studies. UAS systems were implanted in patients with moderate to severe OSA who failed or intolerant continuous positive airway pressure (CPAP)....
Bacterial and viral infections are often clinically indistinguishable, leading to inappropriate patient management antibiotic misuse. Bacterial-induced host proteins such as procalcitonin, C-reactive protein (CRP), Interleukin-6, routinely used support diagnosis of infection. However, their performance is negatively affected by inter-patient variability, including time from symptom onset, clinical syndrome, pathogens. Our aim was identify novel viral-induced that can complement...
Respiratory tract infections (RTI) are more commonly caused by viral pathogens in children than adults. Surprisingly, little is known about antibiotic use as compared to adults with RTI. This prospective study aimed determine misuse and RTI, using an expert panel reference standard, order prioritise the target age population for stewardship interventions. We recruited who presented at emergency department or were hospitalised clinical presentation of RTI The Netherlands Israel. A three...
Abstract Background Diagnostic test evaluation requires a reference standard. We describe an approach for creating standard acute infection using unrestricted adjudication and apply it to compare biomarker tools. Methods Adults children with suspected enrolled in three prospective studies at emergency departments urgent cares were included. Adjudicators, blinded C-reactive protein, procalcitonin, MeMed BV (MMBV), labeled each case (bacterial/viral/non-infectious/indeterminate). Initial...
Abstract Rationale Patients with combined pulmonary fibrosis and emphysema (CPFE) may develop acute exacerbations of IPF (AE-IPF) or COPD (AE-COPD). The incidence the characteristics in patients CPFE (e.g., vs IPF) have not been well described. Objectives To compare rate vs. evaluate their effect on clinical outcomes. Methods Comprehensive data from were retrospectively reviewed. Baseline including lung function data, oxygen requirements, hemodynamics, collected. Acute exacerbation events...
Chronic stimulation of the hypoglossus nerve may provide a new treatment modality for obstructive sleep apnoea (OSA). In previous studies we observed large differences in response to genioglossus (GG). We hypothesised that both individual patient characteristics and area GG stimulated are responsible these differences. present study, compared electrical at anterior (GGa-ES), which activates whole posterior (GGp-ES), preferentially longitudinal fibres. Studies were performed 14...
Pharyngeal collapsibility during sleep is believed to increase due a decline in dilator muscle activity. However, genioglossus electromyogram (EMG) often increases apnoeas and hypopnoeas, without mechanical effect. 17 patients with obstructive apnoea were anaesthetised evaluated from termination of propofol administration awakening. Genioglossus EMG, flow pharyngeal area (pharyngoscopy) monitored. Prolonged hypopnoeas enabled evaluation the relationships between EMG events, before after...
Pharyngeal collapsibility during sleep increases primarily due to decline in dilator muscle activity. However, genioglossus EMG is known increase apneas and hypopneas, usually without reversing upper airway obstruction or inspiratory flow limitation. The present study was undertaken test the hypothesis that intense activation of fails prevent pharyngeal sleep, evaluate if sleep-induced changes tongue coordination may be responsible for this phenomenon. We compared retractors activity 13...
In patients with obstructive sleep apnea (OSA), substantial increases in genioglossus (GG) activity during hypopneas/apneas usually fail to restore normal airflow. We have previously suggested that sleep-induced alteration tongue muscle coordination may explain this finding, as retractor coactivation was reduced compared wakefulness. The present study undertaken evaluate whether these alterations dilator activation play a role the pathogenesis of OSA and additional peripharyngeal muscles...
Chronic obstructive pulmonary disease (COPD) is a heterogeneous with different clinical and pathophysiologic phenotypes. 1,2COPD currently the third leading cause of death in world. 3Chronic bronchitis (CB) common, affecting approximately 10 million people United States, majority which are between 44 65 years age.CB classically described as chronic cough sputum for at least 3 months year 2 consecutive 4 but many studies have used definitions.No matter how it described, clear that CB...
Background Tezepelumab, a monoclonal antibody targeting thymic stromal lymphopoietin (TSLP), has demonstrated efficacy for severe asthma in clinical trials, but real-world evidence remains limited. We aimed to evaluate the characteristics and outcomes of patients initiating Tezepelumab setting. Methods conducted retrospective, multicenter cohort study across four tertiary care centers effectiveness with asthma. Eligible were adults confirmed diagnosis asthma, treated Tezepelumab. Data on...
Introduction: Pulse oximetry is a widely used non-invasive method to measure arterial oxygen saturation (SpO2). However, haemoglobinopathies, including rare low-oxygen-affinity variants such as haemoglobin (Hb) Lansing can result in falsely low SpO2 readings due alterations the Hb dissociation curve and spectral properties. Recognising these conditions crucial avoid misdiagnosis unnecessary interventions. Case description: A 50-year-old female with history of chronic obstructive pulmonary...
Background Pulmonary hypertension (PH) causes increased morbidity and mortality in patients with interstitial lung diseases (ILD). Classification schemes, while well-characterised for the vasculopathy of idiopathic PH, have been applied, unchallenged, to ILD-related PH. We evaluated pulmonary arterial histopathology explanted human tissue from who were transplanted advanced fibrotic ILD. Methods Lung explants 38 adult underwent transplantation included. Patients divided into three groups:...
Background/Objectives: Asthma is a chronic inflammatory disorder of the airways affecting over 10% global population. It characterized by airway inflammation, mucus hypersecretion, and bronchial hyperresponsiveness, driven predominantly type 2 helper T cells (Th2) innate lymphoid (ILC2s) in subset patients. However, significant portion asthmatic individuals present with "type 2-low" asthma, often refractory to standard inhaled corticosteroid (ICS) therapy. Therefore,...
Asthma is a chronic inflammatory disorder of the airways affecting over 10% global population. It characterized by airway inflammation, mucus hypersecretion, and bronchial hyperresponsiveness, driven predominantly type 2 helper T cells (Th2) innate lymphoid (ILC2s) in subset patients. However, significant portion asthmatic individuals present with "type 2-low" asthma that often refractory to standard inhaled corticosteroid (ICS) therapy. Therefore, developing innovative therapeutic...
Percutaneous liver biopsy (PLB) is a common procedure in patients with disease. Bleeding after PLB rare, an incidence of 0.35%. Most bleeding complications present within 24 h biopsy. A 56-year-old woman was admitted to our hospital due severe and sudden right upper quadrant (RUQ) abdominal pain 10 days ultrasound (US)-guided PLB. CT study revealed both intrahepatic intraperitoneal bleeding, Hb levels decreased by 3.2 g/dl few hours. Such prolonged delay PLB-related has not been previously...
Idiopathic pulmonary fibrosis (IPF) is characterised by constant threat of acute exacerbation IPF (AE-IPF). It would be significant to identify risk factors AE-IPF. We sought determine the prognostic value lung transplantation candidacy testing for AE-IPF and describe explant pathology recipients with without before transplantation.Retrospective cohort study 89 patients listed transplantation. Data included function testing, echocardiography, right heart catheterisation, imaging, oesophageal...
Respiratory stimulation (RS) during sleep often fails to discontinue flow limitation, whereas electrical (ES) of the hypoglossus (HG) nerve frequently prevents obstruction. The present work compares effects RS and HG-ES on pharyngeal mechanics relative contribution tongue muscles thoracic forces patency. We determined pressure-area relationship collapsible segment pharynx in anesthetized pigs under following three conditions: baseline (BL), induced by partial obstruction tracheostomy tube,...