A5024727242- Lung Cancer Treatments and Mutations
- Cancer Genomics and Diagnostics
- Cervical Cancer and HPV Research
- Lymphoma Diagnosis and Treatment
- Head and Neck Cancer Studies
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Lung Cancer Research Studies
- Cancer-related molecular mechanisms research
- Chronic Lymphocytic Leukemia Research
- Cancer-related gene regulation
- Cancer Immunotherapy and Biomarkers
- Colorectal Cancer Treatments and Studies
- Genetic factors in colorectal cancer
- Molecular Biology Techniques and Applications
- Immune Cell Function and Interaction
- Endometrial and Cervical Cancer Treatments
- Lung Cancer Diagnosis and Treatment
- CAR-T cell therapy research
- Radiomics and Machine Learning in Medical Imaging
- Cancer-related Molecular Pathways
- Cancer Cells and Metastasis
- Viral-associated cancers and disorders
- Immunotherapy and Immune Responses
- Sarcoma Diagnosis and Treatment
University Medical Center Groningen
2016-2025
University of Groningen
2016-2025
Universität Hamburg
2025
University Medical Center Hamburg-Eppendorf
2025
The Netherlands Cancer Institute
1985-2023
University of Liège
2023
Gynecologic Oncology Group
2021
Target (United States)
2021
Deutschen Konsortium für Translationale Krebsforschung
2020
Dialyse Centrum Groningen
2015-2019
Abstract Objectives In non‐small cell lung cancer (NSCLC), the immune system and possibly its composition affect survival. this in silico study, infiltrate NSCLC patients was evaluated. Methods Gene expression data of tumors from early were obtained Expression Omnibus (GEO). With CIBERSORT, 22 fractions estimated. Results The 1430 pretreatment contained mostly plasma cells, macrophages CD8 T cells. Higher resting mast CD4 T‐helper cells associated with longer overall survival (OS) (HR =...
Cancer patients benefit from early tumor detection since treatment outcomes are more favorable for less advanced cancers. Platelets involved in cancer progression and considered a promising biosource detection, as they alter their RNA content upon local systemic cues. We show that tumor-educated platelet (TEP) RNA-based blood tests enable the of 18 types. With 99% specificity asymptomatic controls, thromboSeq correctly detected presence two-thirds 1,096 samples stage I–IV half 352 I–III...
Abstract Purpose: To find molecular markers from expression profiling data to predict recurrence of laryngeal cancer after radiotherapy. Experimental Design: We generated gene on pre-treatment biopsies 52 larynx patients. Patients developing a local were matched for T-stage, subsite, treatment, gender and age with non-recurrence Candidate genes then tested by immunohistochemistry tumor material second series 76 Both comprised early stage treated radiotherapy alone. Finally, eight cell lines...
Outcome of diffuse large B-cell lymphoma (DLBCL) with a germinal center (GCB) expression profile is superior to that non-GCB DLBCL. This conclusion mainly derived from patients mixed international prognostic index (IPI) risk profiles treated CHOP-like therapy (cyclophosphamide, doxorubicin, vincristine, and prednisone). We wondered whether the impact would hold out in homogeneous cohort poor-risk DLBCL high-dose sequential (HDT) autologous stem-cell transplantation (ASCT) as first-line...
Type-specific high-risk HPV (hrHPV) infection is related to cervical carcinogenesis. The prevalence of hrHPV varies geographically, which might reflect the epidemiological characteristics cancer among different populations. To establish a foundation for HPV-based screening and vaccination programs in China, we investigated most recent genotypic distributions female age groups geographical regions China.In 2012, total 120,772 liquid-based cytological samples from women enrolled population- or...
Abstract DNA methylation has a role in mediating epigenetic silencing of CpG island genes cancer and other diseases. Identification all gene promoters methylated cells “the methylome” would greatly advance our understanding regulatory networks tumorigenesis. We previously described new method identifying tumor suppressor based on pharmacologic unmasking the promoter region detection re-expression microarray analysis. In this study, we modified improved selection candidates structure...
In cancer patients, circulating cell-free DNA (ccfDNA) can contain tumor-derived (ctDNA), which enables noninvasive diagnosis, real-time monitoring, and treatment susceptibility testing. However, ctDNA fractions are highly variable, challenges downstream applications. Therefore, established preanalytical work flows in combination with cost-efficient reproducible reference materials for ccfDNA analyses crucial analytical validity subsequently clinical decision-making.We describe the efforts...
Presence of pelvic lymph node metastases is the main prognostic factor in early-stage cervical cancer patients, primarily treated with surgery. Aim this study was to identify cellular tumor pathways associated metastasis cancer.Gene expression profiles (Affymetrix U133 plus 2.0) 20 patients negative (N(0)) and 19 positive nodes (N(+)), were compared gene sets that represent all 285 presently available pathway signatures. Validation immunostaining tumors 274 consecutive performed for...
Non-small cell lung cancer (NSCLC) patients treated with checkpoint inhibitors show long lasting responses, but it is hard to predict which will profit from this treatment the currently used marker, programmed death ligand 1 (PD-L1). We hypothesized that circulating tumor cells (CTC) or derived extracellular vesicles (tdEV) are markers of efficacy.Patients advanced NSCLC were included. Blood was drawn at baseline (T0) and 4 weeks (T1) for analysis CTC tdEV using CellSearch®. Tumor response...
Abstract Background Liquid biopsy testing, especially molecular tumor profiling of circulating DNA (ctDNA) in cell-free plasma, has received increasing interest recent years as it serves a reliable alternative for the detection tumor-specific aberrations to guide treatment decision-making oncology. Many (commercially available) applications have been developed, however, broad divergences (pre)analytical work flows and lack universally applied guidelines impede routine clinical...