Govert Dwarshuis
A5013325506- Cancer-related molecular mechanisms research
- Extracellular vesicles in disease
- Cancer Genomics and Diagnostics
- Migraine and Headache Studies
- MicroRNA in disease regulation
- Pancreatic and Hepatic Oncology Research
- Sarcoma Diagnosis and Treatment
- Sympathectomy and Hyperhidrosis Treatments
- Ophthalmology and Eye Disorders
Amsterdam University Medical Centers
2020-2022
Vrije Universiteit Amsterdam
2022
GGD Amsterdam
2021
Cancer patients benefit from early tumor detection since treatment outcomes are more favorable for less advanced cancers. Platelets involved in cancer progression and considered a promising biosource detection, as they alter their RNA content upon local systemic cues. We show that tumor-educated platelet (TEP) RNA-based blood tests enable the of 18 types. With 99% specificity asymptomatic controls, thromboSeq correctly detected presence two-thirds 1,096 samples stage I–IV half 352 I–III...
Sarcoma is a heterogeneous group of rare malignancies arising from mesenchymal tissues. Recurrence rates are high and methods for early detection by blood-based biomarkers do not exist. Hence, development liquid biopsies as disease recurrence monitoring would be an important step forward. Recently, it has been shown that tumor-educated platelets (TEPs) harbor specific spliced ribonucleic acid(RNA)-profiles. These RNA-repertoires potentially applicable cancer diagnostics. We aim to evaluate...
A 46-year-old man presented in the emergency department with nausea, vertigo, dysphagia, and hiccups. Vascular risk factors included hypertension, hypercholesterolemia, smoking. Ptosis subtle miosis of left eye, torsional nystagmus, left-sided hemiataxia were found. The patient was sweating heavily, however not on side his face. To objectively evaluate this, Minor's starch-iodine test performed.1 Anhidrosis confirmed by observing color difference respecting midline that resulted from...