A5083654901- Pulmonary Hypertension Research and Treatments
- Liver Disease and Transplantation
- Cancer-related molecular mechanisms research
- Hepatocellular Carcinoma Treatment and Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatic and Hepatic Oncology Research
- Transplantation: Methods and Outcomes
- Anesthesia and Sedative Agents
- Fibroblast Growth Factor Research
- Pediatric Hepatobiliary Diseases and Treatments
- Angiogenesis and VEGF in Cancer
- Extracellular vesicles in disease
- Cardiovascular Function and Risk Factors
- Vascular Anomalies and Treatments
- Heart Failure Treatment and Management
- Chronic Myeloid Leukemia Treatments
- Nausea and vomiting management
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Atrial Fibrillation Management and Outcomes
- Congenital Heart Disease Studies
- Congenital heart defects research
- Tracheal and airway disorders
- Chronic Lymphocytic Leukemia Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Acute Lymphoblastic Leukemia research
Vrije Universiteit Amsterdam
2020-2023
Amsterdam University Medical Centers
2018-2023
Amsterdam Neuroscience
2023
Maastricht University
2023
Amsterdam UMC Location Vrije Universiteit Amsterdam
2018-2022
Pulmonary Associates
2017
Stichting tot Steun VCVGZ
1978
Cancer patients benefit from early tumor detection since treatment outcomes are more favorable for less advanced cancers. Platelets involved in cancer progression and considered a promising biosource detection, as they alter their RNA content upon local systemic cues. We show that tumor-educated platelet (TEP) RNA-based blood tests enable the of 18 types. With 99% specificity asymptomatic controls, thromboSeq correctly detected presence two-thirds 1,096 samples stage I–IV half 352 I–III...
The major complication of COVID-19 is hypoxaemic respiratory failure from capillary leak and alveolar oedema. Experimental early clinical data suggest that the tyrosine-kinase inhibitor imatinib reverses pulmonary leak. This randomised, double-blind, placebo-controlled, trial was done at 13 academic non-academic teaching hospitals in Netherlands. Hospitalised patients (aged ≥18 years) with COVID-19, as confirmed by an RT-PCR test for SARS-CoV-2, requiring supplemental oxygen to maintain a...
BackgroundTo investigate the association between altered sex hormone expression and long-term right ventricular (RV) adaptation progression of heart failure in a Dutch cohort Pulmonary Arterial Hypertension (PAH)-patients across wide range ages.MethodsIn this study we included 279 PAH-patients, which 169 females 110 males. From 59 patients 21 controls collected plasma samples for analysis. Right catheterization (RHC) and/or cardiac magnetic resonance (CMR) imaging was performed at baseline....
In pulmonary arterial hypertension (PAH), lung-angioproliferation leads to increased vascular resistance, while simultaneous myocardial microvessel loss contributes right ventricular (RV) failure. Endothelial colony forming cells (ECFC) are highly proliferative, angiogenic that may contribute either obstruction or RV microvascular adaptation. We hypothesize ECFC phenotypes (outgrowth, proliferation, tube formation) related markers of disease severity in a prospective cohort-study 33 PAH and...
Background Pulmonary endarterectomy (PEA) for chronic thromboembolic pulmonary hypertension improves resting hemodynamics and right ventricular (RV) function. Because exercise tolerance frequently remains impaired, RV function may not have completely normalized after PEA. Therefore, we performed a detailed invasive hemodynamic study to investigate the effect of PEA on during exercise. Methods Results In this prospective study, all consenting patients with eligible surgery able perform cycle...
Domperidone was compared with placebo in a multicenter double-blind study of 116 patients (15 to 80 years) postoperative vomiting. After vomiting had occurred, the received either domperidone 10 mg or IV. Patients were then followed for at least 6 hours until 2nd injection from an open supply needed. The period time additional registered and between 2 treatment groups. Fifty-nine percent needed before end 6-hour follow-up, only 35% (p<0.05). When required, elapsed it longer (p = 0.01) group...
Rationale: Pulmonary hypertension encompasses progressive disorders leading to right ventricular dysfunction and early death. Late detection is an important cause of poor clinical outcomes. However, biomarkers that accurately predict the presence pulmonary are currently lacking. Objectives: In this study, we provide evidence blood platelets contain a distinctive ribonucleic acid (RNA) profile may be exploited for hypertension. Methods: Blood platelet RNA was isolated prospectively from 177...
In Pulmonary Arterial Hypertension (PAH) structural and functional abnormalities in the lung lead to an increased pulmonary vascular resistance right heart failure. Dysfunction of pressure-regulating endothelial cells (ECs) is thought play crucial role. Recently it was shown our laboratory that biopsy derived microvascular ECs (MVECs) from PAH-patients are unable align under 120h high shear stress. As availability these limited, a suitable alternative needed. Our aim investigate ECFC as...
Background Appropriate treatment of pulmonary hypertension (PH) is critically dependent on accurate discrimination between pre- and postcapillary PH. However, clinical challenging frequently requires a right heart catheterization. Existing risk scores to detect PH have suboptimal discriminatory strength. We previously shown that platelet-derived RNA profiles may diagnostic value for detection. Here, we hypothesize RNAs can be employed select unique biomarker panels the Methods Results Blood...
Pulmonary arterial hypertension (PAH) is associated with angioproliferation in the lung and, paradoxically, vascular rarefaction right ventricle (RV). Endothelial colony forming cells (ECFC) are angioproliferative endothelial implicated tissue repair. Here we investigated wether ECFC characteristics correlate disease severity, pulmonary resistance (PVR) and RV-function. <b>Methods:</b> were collected from 36 PAH 21 healthy donors. Proliferation angiogenic capacity upon GF stimulation...
HR 0.51 {95%CI 0.27 to 0.96}, P=0.03) Bleeding events, especially intracranial bleeding, were lower in the combined therapy arms, but gastric bleeding was more frequent with this therapy.In summary: events-rate during antithrombotic similar nonvalvular and MS Pts, despite Pts younger than AF patients have significantly incidence of another risk factors.Pts prior embolism a higher new vascular events spite Aco therapy.Combined reduced compared alone.
<b>Background:</b> Discrimination between pre- and post-capillary Pulmonary Hypertension (PH) is challenging often requires invasive right heart catherization. Platelet-derived RNA signatures may have predictive value for tumour diagnostics. We hypothesize that platelet can be exploited to select unique biomarker RNA-panels the distinction post- pre-capillary PH. <b>Method:</b> isolated platelets from whole blood 50 PH patients. Platelet pellets were subjected total isolation, SMARTer cDNA...
<b>Introduction:</b> COVID-19 is often complicated by hypoxemic respiratory failure, resulting from widespread capillary leak. The kinase inhibitor imatinib may protect the endothelial barrier and reverse pulmonary <b>Methods:</b> This was a randomized, double-blind, placebo-controlled trial. Hospitalized patients requiring supplemental oxygen were randomized to oral (800mg loading dose, followed 400mg daily for 9 days) or placebo on top of standard care. primary outcome was time...