A5005140861- Acute Lymphoblastic Leukemia research
- Cancer Immunotherapy and Biomarkers
- Hematopoietic Stem Cell Transplantation
- Lung Cancer Treatments and Mutations
- Pharmacogenetics and Drug Metabolism
- Chronic Myeloid Leukemia Treatments
- Acute Myeloid Leukemia Research
- Antibiotics Pharmacokinetics and Efficacy
- Drug Transport and Resistance Mechanisms
- Chronic Lymphocytic Leukemia Research
- HER2/EGFR in Cancer Research
- Neuroendocrine Tumor Research Advances
- Lung Cancer Research Studies
- Cancer therapeutics and mechanisms
- PARP inhibition in cancer therapy
- Antifungal resistance and susceptibility
- Neuroblastoma Research and Treatments
- Salivary Gland Disorders and Functions
- Colorectal Cancer Treatments and Studies
- Glioma Diagnosis and Treatment
- Cancer Treatment and Pharmacology
- Salivary Gland Tumors Diagnosis and Treatment
- HIV/AIDS drug development and treatment
- Mass Spectrometry Techniques and Applications
- Lung Cancer Diagnosis and Treatment
Amsterdam University Medical Centers
2018-2025
Amsterdam UMC Location Vrije Universiteit Amsterdam
2020-2025
Vrije Universiteit Amsterdam
2018-2025
Cancer Center Amsterdam
2020-2025
University Medical Center Utrecht
2006-2021
University of California, San Francisco
2013-2019
University of California San Francisco Medical Center
2017
University of San Francisco
2013
Utrecht University
2012
Centre for Human Drug Research
2012
The major complication of COVID-19 is hypoxaemic respiratory failure from capillary leak and alveolar oedema. Experimental early clinical data suggest that the tyrosine-kinase inhibitor imatinib reverses pulmonary leak. This randomised, double-blind, placebo-controlled, trial was done at 13 academic non-academic teaching hospitals in Netherlands. Hospitalised patients (aged ≥18 years) with COVID-19, as confirmed by an RT-PCR test for SARS-CoV-2, requiring supplemental oxygen to maintain a...
Abstract Over the past decade, several immunotherapies have been approved for treatment of melanoma. The most prominent these are immune checkpoint inhibitors, which antibodies that block inhibitory effects on system by receptors, such as CTLA-4, PD-1 and PD-L1. Preclinically, blocking receptors has led to increased activation proliferation effector cells following stimulation antigen recognition, subsequently, more effective elimination cancer cells. Translation from preclinical clinical...
The blood–brain barrier (BBB) represents a major obstacle to delivering drugs the central nervous system (CNS), resulting in lack of effective treatment for many CNS diseases including brain cancer. To accelerate drug development, computational prediction models could save time and effort needed experimental evaluation. Here, we studied BBB permeability focusing on active transport (influx efflux) as well passive diffusion using previously published self-curated data sets. We created based...
Invasive fungal infections are of great concern in pediatric hematopoietic stem cell transplantation (HSCT) recipients. Voriconazole is usually the drug first choice for treating or preventing invasive aspergillosis. Optimum trough levels (C(trough)s) between 1 and 5 mg/liter. It unclear whether these reached with currently advised dosing schedules. Between 2007 2011, 11 patients <2 years age, 31 2 12 years, 20 were (prophylactically therapeutically) treated voriconazole HSCT unit UMC...
Immunotherapy and immune checkpoint blocking antibodies such as anti-PD-1 are approved significantly improve the survival of advanced non-small cell lung cancer (NSCLC) patients, but there has been little success in identifying biomarkers capable separating responders from non-responders before onset therapy. In this study, we developed a quantitative system pharmacology (QSP) model to represent anti-tumor response human NSCLC that integrated our knowledge tumor growth, antigen processing...
The low response rate of immune checkpoint blockade in breast cancer has highlighted the need for predictive biomarkers to identify responders. While a number clinical trials are ongoing, testing all possible combinations is not feasible. In this study, quantitative systems pharmacology model built integrate immune-cancer cell interactions patients with cancer, including central, peripheral, tumour-draining lymph node (TDLN) and tumour compartments. can describe suppression evasion both TDLN...
// Marc Ansari 1,2 , Patricia Huezo-Diaz Curtis 1,2,* Chakradhara Rao S. Uppugunduri Mohammed Aziz Rezgui 3 Tiago Nava 1,3,5,6 Vid Mlakar Laurence Lesne Yves Théoret 3,4,5 Chalandon 7 Lee L. Dupuis 8 Tao Schechter Imke H. Bartelink 9,17 Jaap J. Boelens 9 Robbert Bredius 10 Jean-Hugues Dalle 11 Saba Azarnoush Petr Sedlacek 12 Victor Lewis 13 Martin Champagne 14 Christina Peters 15 Henrique Bittencourt 3,4,5,16 and Maja Krajinovic - 5,16,18 1 Department of Pediatrics, CANSEARCH Research...
Intravenous busulfan is widely used as part of myeloablative conditioning regimens in children and young adults undergoing allogeneic hematopoietic cell transplantation (HCT). Hepatic veno-occlusive disease/sinusoidal obstruction syndrome (VOD/SOS) a serious clinical problem observed with busulfan-based HCT. The development VOD/SOS may be associated exposure. Getting more insight into the association between exposure enables further optimization dosing treatment strategies. objective this...
Abstract Background Thrombocytopenia is a major temozolomide-induced adverse event during the standard treatment of glioblastoma. Consequently, platelet transfusions and modifications may impact quality life long-term outcomes. Understanding thrombocytopenia on healthcare utilisation crucial to mitigate need for resources in glioblastoma patients. Here, we assess influence thrombocytopenia-related among patients diagnosed with Methods We retrospectively collected patient information treated...
Androgen receptor–targeting agents, particularly enzalutamide, show promise in enhancing prostate cancer diagnostic and therapeutic strategies by modulating prostate-specific membrane antigen (PSMA). <b>Methods:</b> A retrospective clinical cohort study investigated 9 men with metastatic castration-resistant on enzalutamide. PSMA PET/CT scans were obtained before after enzalutamide initiation to assess expression changes. Lesions organs at risk evaluated visually semiquantitatively. The...
Background: Recently a pediatric pharmacokinetic (PK) model was developed for busulfan to explain the wide variability in PK of children, as this is known influence outcome hematopoietic stem cell transplantation terms toxicity and event free survival. This study assesses predictive performance new, more diverse population, including data from patients with different underlying diseases, ethnicities, body weights, ages, mass indices, 5 international transplant centers. Patients Methods: The...
Quantitative characterization of the tumor microenvironment, including its immuno-architecture, is important for developing quantitative diagnostic and predictive biomarkers, matching patients to most appropriate treatments precision medicine, providing data building systems biology computational models able predict dynamics in context immune checkpoint blockade therapies. The intra- inter-tumoral spatial heterogeneities are potentially key understanding dose-response relationships, but they...
The likelihood of a tumor recurrence in patients with T3-4N0-1 non-small cell lung cancer following multimodality treatment remains substantial, mainly due distant metastases. As pathological complete responses (pCR) resected specimens are seen only minority (28-38%) chemoradiotherapy, we designed the INCREASE trial (EudraCT-Number: 2019-003454-83; Netherlands Trial Register number: NL8435) to assess if pCR rates could be further improved by adding short course immunotherapy induction...
Pregnancy and food insecurity may impact antiretroviral (ART) pharmacokinetics (PK), adherence response. We sought to quantify characterize the PK of lopinavir/ritonavir (LPV/r) efavirenz (EFV) by pregnancy nutritional status among HIV-infected women in Tororo, Uganda. In 2011, 62/225 ante-partum/post-partum single dried blood spot samples DBS 43 post-partum hair for LPV/r were derived from 116 women, 51/194 ante-/post-partum 53 EFV 105 women. Eighty percent Ugandan participants severely...
Epidermal growth factor receptor (EGFR) mutated NSCLC is best treated using an EGFR tyrosine kinase inhibitor (TKI). The presence and accessibility of overexpression mutation in can be determined radiolabeled TKI PET/CT. However, recent research has shown a significant difference between image qualities (i.e., tumor-to-lung contrast) three generation TKIs: 11C-erlotinib, 18F-afatinib 11C-osimertinib. In this we aim to develop physiological pharmacokinetic (PBPK)-model predict contrast as...
Vanishing white matter (VWM) is a leukodystrophy, characterized by stress-sensitive neurological deterioration and premature death. It currently without curative treatment. caused bi-allelic pathogenic variants in the genes encoding eukaryotic initiation factor 2B (eIF2B). eIF2B essential for regulation of integrated stress response (ISR), physiological to cellular stress. Preclinical studies on VWM mouse models revealed that deregulated ISR key pathophysiology an effective treatment target....