A5078814580- Pulmonary Hypertension Research and Treatments
- Cardiovascular Function and Risk Factors
- Vascular Anomalies and Treatments
- COVID-19 Clinical Research Studies
- Lung Cancer Diagnosis and Treatment
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory Support and Mechanisms
- COVID-19 and Mental Health
- Chronic Myeloid Leukemia Treatments
- Radiomics and Machine Learning in Medical Imaging
- Chronic Lymphocytic Leukemia Research
- Cardiovascular Effects of Exercise
- SARS-CoV-2 and COVID-19 Research
- Cardiovascular Issues in Pregnancy
- Cardiovascular Disease and Adiposity
- Acute Lymphoblastic Leukemia research
Suez Canal University
2020-2023
Amsterdam University Medical Centers
2020-2022
Vrije Universiteit Amsterdam
2020-2022
Amsterdam UMC Location Vrije Universiteit Amsterdam
2019-2020
The major complication of COVID-19 is hypoxaemic respiratory failure from capillary leak and alveolar oedema. Experimental early clinical data suggest that the tyrosine-kinase inhibitor imatinib reverses pulmonary leak. This randomised, double-blind, placebo-controlled, trial was done at 13 academic non-academic teaching hospitals in Netherlands. Hospitalised patients (aged ≥18 years) with COVID-19, as confirmed by an RT-PCR test for SARS-CoV-2, requiring supplemental oxygen to maintain a...
BACKGROUND: Surgical removal of thromboembolic material by pulmonary endarterectomy (PEA) leads within months to the improvement right ventricular (RV) function in majority patients with chronic hypertension. However, RV mass does not always normalize. It is unknown whether incomplete reversal remodeling results from extracellular matrix expansion (diffuse interstitial fibrosis) or cellular hypertrophy, and residual relates altered diastolic function. METHODS: We prospectively included 25...
Pulmonary vascular resistance (PVR) and compliance are comparable in proximal distal chronic thromboembolic pulmonary hypertension (CTEPH). However, CTEPH is associated with inferior right ventricular (RV) adaptation. Early wave reflection may be responsible for altered RV function. The aims of the study as follows: 1) to investigate whether reflected pressure returns sooner than 2) elucidate timing related dimensions, ejection fraction (RVEF), hypertrophy, wall stress. Right heart...
The coronavirus disease 2019 (COVID-19) pandemic, which emerged in China at the end of 2019, rapidly spread worldwide. angiotensin-converting enzyme (ACE) gene contains an insertion/deletion (I/D) polymorphism that leads to a higher serum ACE level is associated with several diseases and also high mortality rate SARS. Therefore, this study aimed assessing association between risk severity COVID-19 patients. Methodology. Forty-five SARS-CoV-2 infected patients another random control group 45...
Right ventricular (RV) wall tension in pulmonary arterial hypertension (PAH) is determined not only by pressure, but also RV volume. A larger volume at a given pressure generates more tension. Return of reflected waves early after the onset contraction, when larger, may augment load. We aimed to elucidate: (1) distribution arrival times peak treatment-naïve PAH patients; (2) relationship between time and morphology; (3) effect treatment on waves. Wave separation analysis was conducted 68...
<b>Introduction.</b> The coronavirus disease 2019 (COVID-19) pandemic, which emerged in China at the end of 2019, rapidly spread worldwide. angiotensin-converting enzyme (ACE) gene contains an insertion/deletion (I/D) polymorphism that leads to a higher serum ACE level is associated with several diseases and also high mortality rate SARS. Therefore, this study aimed assessing association between risk severity COVID-19 patients. <b>Methodology.</b> Forty-fve SARS-CoV-2 infected patients...
Abstract Background The Global Initiative for Obstructive Lung Disease (GOLD) staging approach is frequently used to classify the severity of COPD by using spirometry. Recent advancements in artificial intelligence applications enable automatic identification chest computer tomography (CT). goal this study define role determining COPD. Methods We a non-contrast CT and computer-aided detection system (Coreline Soft's AVIEW), which was conducted as descriptive cross sectional involved 80...
<b>Background:</b> Right ventricular (RV) fibrosis contributes partly to the RV diastolic stiffness in pulmonary hypertension (PH), however it is still unknown whether this contribution similar different types of PH. Therefore, we investigated there a relation arterial (PAH) and chronic thromboembolic (CTEPH). <b>Methods:</b> end-diastolic elastance (stiffness, E<sub>ed</sub>) was determined 56 treatment-naive PH patients (PAH, n=37; CTEPH, n=19) via single-beat pressure-volume analyses....
<b>Background:</b> In precapillary pulmonary hypertension (PH), the causal relationships between right ventricular (RV) diastolic stiffness and RV fibrosis or hypertrophy are not well established. <b>Aim:</b> to investigate whether could be attributed in patients with PH. <b>Methods:</b> This is a retrospective study of 31 arterial (PAH) 32 chronic thromboembolic (CTEPH). All underwent cardiac magnetic resonance imaging (CMRI) heart catheterization (RHC) within 30 days interval. Single-beat...