A5021986417- Hemophilia Treatment and Research
- Antibiotics Pharmacokinetics and Efficacy
- Platelet Disorders and Treatments
- Inflammatory Bowel Disease
- Microscopic Colitis
- Pharmacogenetics and Drug Metabolism
- Renal Transplantation Outcomes and Treatments
- Pharmacological Effects and Toxicity Studies
- Blood Coagulation and Thrombosis Mechanisms
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Adenosine and Purinergic Signaling
- Pneumonia and Respiratory Infections
- Pharmaceutical studies and practices
- Anesthesia and Sedative Agents
- Acute Lymphoblastic Leukemia research
- Cancer Treatment and Pharmacology
- Drug Transport and Resistance Mechanisms
- Epilepsy research and treatment
- Pharmacological Receptor Mechanisms and Effects
- Antibiotic Resistance in Bacteria
- Biosimilars and Bioanalytical Methods
- Bipolar Disorder and Treatment
- Synthesis and Biological Evaluation
- Cystic Fibrosis Research Advances
- Chemotherapy-induced organ toxicity mitigation
University of Amsterdam
2016-2025
Amsterdam University Medical Centers
2019-2025
Erasmus MC - Sophia Children’s Hospital
2013-2024
Amalia Kinderziekenhuis
2024
University Medical Center Groningen
2024
University of Groningen
2024
University of Washington
2023
Amsterdam UMC Location University of Amsterdam
2012-2022
Amsterdam University of the Arts
2014
University of Florida
2014
Importance Continuous morphine infusion as standard postoperative analgesic therapy in young infants is associated with unwanted adverse effects such respiratory depression.Objective To determine whether intravenous paracetamol (acetaminophen) would significantly (Ͼ30%) reduce requirements neonates and after major surgery.Design, Setting, Patients Single-center, randomized, double-blind study conducted a level 3 pediatric intensive care unit Rotterdam, the Netherlands.Patients were 71 or...
The benefits of a pharmacy-based, active therapeutic drug monitoring (TDM) service (ATM) on outcomes were examined in prospective study at four hospitals. ATM involved pharmacokinetic dosage optimization the start treatment, subsequent Bayesian adaptive control, and frequent patient evaluation. Cost-effectiveness was calculated based real costs. group comprised 105 patients 127 with nonguided TDM who followed up as controls. Forty-eight 62 had an infection admission. Peak concentrations...
The aim of this in vitro study was to evaluate potential determinants drug loss different ECMO circuits.Midazolam, morphine, fentanyl, paracetamol, cefazolin, meropenem and vancomycin were injected into three neonatal roller pump, two paediatric pump clinically used circuits, all with a silicone membrane, centrifugal circuits polypropylene hollow-fibre membranes. Serial blood samples taken from post-oxygenator site. Drug recovery calculated as the ratio between determined theoretical maximum...
Background. We hypothesized that a high within-patient variability in clearance of tacrolimus and mycophenolate mofetil (MMF) would put patients at risk for periods over- or underimmunosuppression thus lead to long-term chronic allograft nephropathy graft loss after transplantation. Methods. From 297 transplanted between 1 January 2000 31 December 2004, the was calculated from whole-blood concentrations mycophenolic acid (MPA) plasma drawn 6 12 months post-transplantation. As primary...
Loss of response to anti-tumour necrosis factor (TNF) therapy in patients with inflammatory bowel disease (IBD) is often caused by anti-drug antibody formation neutralisation drug effect. Addition an immunomodulator has been suggested reduce immunogenicity, leading regained response.To investigate whether addition anti-TNF monotherapy could lead suppression and clinical IBD patients.We retrospectively collected measurements infliximab or adalimumab serum concentrations antibodies identify...
Objectives Loss of response (LOR) to infliximab (IFX) remains a challenge in the management inflammatory bowel diseases (IBD). Proactive dosing strategies achieve and maintain predefined IFX trough levels (TL) may prevent LOR. We aimed investigate efficacy dashboard driven compared standard prospective trial IBD patients.Methods In this multicentre 1:1 'PRECISION' trial, we randomized patients clinical remission (Harvey Bradshaw Index ≤4 for Crohn's disease (CD) or partial Mayo score ≤2...
Abstract Background Adequate antibiotic dosing may improve outcomes in critically ill patients but is challenging due to altered and variable pharmacokinetics. To address this challenge, AutoKinetics was developed, a decision support system for bedside, real-time, data-driven personalised dosing. This study evaluates the feasibility, safety efficacy of its clinical implementation. Methods In two-centre randomised trial, with sepsis or septic shock were standard four antibiotics: vancomycin,...
Cases have been reported that suggest extracts from St John's wort (Hypericum perforatum), mainly used as an antidepressant [1], contain potent inducers of hepatic enzymes, raising the possibility clinically relevant drug interactions. Recent pharmacokinetic data show substantially decreased exposure to antiretroviral indinavir by concomitant use wort, probably because induction 3A4 isoform cytochrome P450 system. reduced area under plasma concentration versus time curve 57% (SD 19%), and...
In end-of-life care, symptoms of discomfort are mainly managed by drug therapy, the guidelines for which based on expert opinions. A few papers have inventoried prescriptions in palliative care settings, but none has reported frequency use combination with doses and route administration.To describe routes administration most frequently used drugs at admission day death. Setting Palliative centre Netherlands.In this retrospective cohort study, prescription data deceased patients were...
Introduction High-grade chondrosarcoma, high-grade glioma and intrahepatic cholangiocarcinoma are aggressive types of cancer with a dismal outcome. This is due to the lack effective treatment options, emphasising need for novel therapies. Mutations in genes IDH1 IDH2 (isocitrate dehydrogenase 1 2) occur 60% 80% WHO grade II–IV 20% cholangiocarcinoma. IDH1/2 -mutated cells produce oncometabolite D -2-hydroxyglutarate ( -2HG) metabolically vulnerable oral antidiabetic metformin antimalarial...
Approximately 15% to 43% of esophageal adenocarcinomas (EACs) are human epidermal growth factor receptor 2 (HER2) positive. Because dual-agent HER2 blockade demonstrated a survival benefit in breast cancer, we conducted phase II feasibility study trastuzumab and pertuzumab added neoadjuvant chemoradiotherapy (nCRT) patients with EAC.
Pharmacometrics is a multidisciplinary field utilizing mathematical models of physiology, pharmacology, and disease to describe quantify the interactions between medication patient. As these become more advanced, need for advanced data analysis tools grows. Recently, there has been much interest in adoption machine learning (ML) algorithms. These algorithms offer strong function approximation capabilities might reduce time spent on model development. However, ML are not yet an integral part...
Therapeutic drug monitoring (TDM) of elexacaftor, tezacaftor, ivacaftor (ETI) could be a useful tool to increase efficacy and decrease the risk adverse effects in people with Cystic Fibrosis (pwCF). It is however unclear whether exposure should monitored by assessment trough (C