A5068172953- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Functional Brain Connectivity Studies
- HIV-related health complications and treatments
- Medical Imaging Techniques and Applications
- HIV Research and Treatment
- Neurological disorders and treatments
- Radiomics and Machine Learning in Medical Imaging
- MRI in cancer diagnosis
- Fetal and Pediatric Neurological Disorders
- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- HIV/AIDS Research and Interventions
- Parkinson's Disease Mechanisms and Treatments
- Medical Image Segmentation Techniques
- Scientific Computing and Data Management
- Tensor decomposition and applications
- Atomic and Subatomic Physics Research
- Receptor Mechanisms and Signaling
- Neuroscience and Neuropharmacology Research
- Cytomegalovirus and herpesvirus research
- Neurotransmitter Receptor Influence on Behavior
- Distributed and Parallel Computing Systems
- Sparse and Compressive Sensing Techniques
- Treatment of Major Depression
Amsterdam University Medical Centers
2018-2025
University of Amsterdam
2016-2025
Oslo University Hospital
2022-2025
Amsterdam Neuroscience
2012-2024
Radboud University Medical Center
2014-2024
Radboud University Nijmegen
2014-2024
Stichting HIV Monitoring
2015-2023
Amsterdam UMC Location University of Amsterdam
2011-2020
Novem (Netherlands)
2020
Amsterdam University of Applied Sciences
2019-2020
Human immunodeficiency virus (HIV)-infected individuals may be at increased risk of age-associated noncommunicable comorbidities (AANCCs).Cross-sectional analyses AANCC prevalence (including cardiovascular, metabolic, pulmonary, renal, bone, and malignant disease) factors in a prospective cohort study HIV type 1-infected HIV-uninfected controls, who were aged ≥45 years comparable regarding most lifestyle demographic factors.HIV-infected participants (n = 540) had significantly higher mean...
Abstract The neural substrate underlying cognitive impairments after chemotherapy is largely unknown. Here, we investigated very late (>9 years) effects of adjuvant high‐dose on brain white and gray matter in primary breast cancer survivors ( n = 17) with multimodal magnetic resonance imaging (MRI). A group who did not receive was scanned for comparison 15). Neuropsychological tests demonstrated the group. Diffusion tensor (DTI) tract‐based spatial statistics showed that associated focal...
The segmentation and volumetric quantification of white matter (WM) lesions play an important role in monitoring studying neurological diseases such as multiple sclerosis (MS) or cerebrovascular disease. This is often interactively done using 2D magnetic resonance images. Recent developments acquisition techniques allow for 3D imaging with much thinner sections, but the large number images per subject makes manual lesion outlining infeasible. warrants need a reliable automated approach. Here...
<h3>Objective:</h3> To establish whether HIV disease is associated with abnormal levels of age-related brain atrophy, by estimating apparent age using neuroimaging and exploring these estimates related to status, age, cognitive performance, HIV-related clinical parameters. <h3>Methods:</h3> A large sample virologically suppressed HIV-positive adults (n = 162, 45–82 years) highly comparable HIV-negative controls 105) were recruited as part the Comorbidity in Relation AIDS (COBRA)...
Response to antidepressant treatment in major depressive disorder varies substantially between individuals, which lengthens the process of finding effective treatment. The authors sought determine whether a multimodal machine learning approach could predict early sertraline response patients with disorder. They assessed predictive contribution MR neuroimaging and clinical assessments at baseline after 1 week
American children consume up to 27% of calories from high-fat and high-sugar snacks. Both sugar fat consumption have been implicated as a cause hepatic steatosis obesity but the effect meal pattern is largely understudied. We hypothesized that high frequency, compared consuming large meals, detrimental in accumulation intrahepatic abdominal fat. To test this hypothesis, we randomized 36 lean, healthy men 40% hypercaloric diet for 6 weeks or eucaloric control measured triglyceride content...
Motoneuron disease is a term encompassing three phenotypes defined largely by the balance of upper versus lower motoneuron involvement, namely amyotrophic lateral sclerosis, primary sclerosis and progressive muscular atrophy. However, neuroradiological pathological findings in these suggest that degeneration may exceed neuronal system upon which clinical diagnosis based. To further delineate within spectrum, this controlled study assessed upper- extra-motoneuron white matter involvement...
Arterial spin labeling (ASL) has undergone significant development since its inception, with a focus on improving standardization and reproducibility of acquisition quantification. In community-wide effort towards robust reproducible clinical ASL image processing, we developed the software package ExploreASL, allowing standardized analyses across centers scanners. The procedures used in ExploreASL capitalize published processing advancements address challenges multi-center datasets...
Macro-vascular artifacts are a common arterial spin labeling (ASL) finding in populations with prolonged transit time (ATT) and result vascular regions spuriously increased cerebral blood flow (CBF) tissue decreased CBF. This study investigates whether there is an association between the spatial signal distribution of single post-label delay ASL CBF image ATT. In 186 elderly hypertension (46% male, 77.4 ± 2.5 years), we evaluated associations coefficient variation (CoV) The CoV ATT metrics...
Despite successful antiretroviral therapy, people living with human immunodeficiency virus (PLWH) experience higher rates of age-related morbidity, including abnormal brain structure, function, and cognitive impairment. This has raised concerns that PLWH may accelerated aging-related pathology. We performed a multicenter longitudinal study 134 virologically suppressed (median age, 56.0 years) 79 demographically similar (HIV)–negative controls 57.2 years). To measure performance pathology, we...
The ventral anterior limb of the internal capsule (vALIC) is a target for deep brain stimulation (DBS) in obsessive-compulsive disorder (OCD). Conventional surgical planning based on anatomical landmarks.We hypothesized that treatment response depends location active DBS contacts with respect to individual white matter bundle trajectories. This study thus aimed elucidate whether vALIC can benefit from bundle-specific targeting.We performed tractography analysis two fiber bundles, thalamic...
Abstract Mid-level visual processing represents a crucial stage between basic sensory input and higher-level object recognition. The conventional model posits that fundamental qualities like color motion are processed in specialized, retinotopic brain regions (e.g., V4 for color, MT/V5 motion). Using atlas-based lesion-symptom mapping disconnectome maps cohort of 307 ischemic stroke patients, we examined the neuroanatomical correlates underlying eight mid-level qualities. Contrary to...
Four unrelated children are described with an identical brainstem and cerebellar malformation on MRI. The key findings are: vermal hypoplasia, subtotal absence of middle peduncles, flattened ventral pons, vaulted pontine tegmentum, molar tooth aspect the pontomesencephalic junction absent inferior olivary prominence. Peripheral hearing impairment is present in all. Variable horizontal gaze palsy (1/4), impaired swallowing (2/4), facial (3/4), bilateral sensory trigeminal nerve involvement...
Objective: The objective of this study is to assess whether multivariate normative comparison (MNC) improves detection HIV-1-associated neurocognitive disorder (HAND) as compared with Frascati and Gisslén criteria. Methods: One-hundred three HIV-1-infected men suppressed viremia on combination antiretroviral therapy (cART) for at least 12 months 74 HIV-uninfected male controls (comparable regarding age, ethnicity, sexual orientation, premorbid intelligence educational level), aged 45 years,...
Objectives: The objective of this study was to assess whether HIV-infected patients on long-term successful combination antiretroviral therapy (cART) have more extensive white matter hyperintensities (WMH) presumed vascular origin compared with uninfected controls and these intensities are associated cognitive impairment. Furthermore, we explored potential determinants increased WMH load suppressed HIV infection. Design: A cross-sectional comparison in an observational cohort. Methods:...
Introduction High-grade chondrosarcoma, high-grade glioma and intrahepatic cholangiocarcinoma are aggressive types of cancer with a dismal outcome. This is due to the lack effective treatment options, emphasising need for novel therapies. Mutations in genes IDH1 IDH2 (isocitrate dehydrogenase 1 2) occur 60% 80% WHO grade II–IV 20% cholangiocarcinoma. IDH1/2 -mutated cells produce oncometabolite D -2-hydroxyglutarate ( -2HG) metabolically vulnerable oral antidiabetic metformin antimalarial...
Abstract Quantitative magnetic resonance imaging generates images of meaningful physical or chemical variables measured in units that allow quantitative comparisons between tissue regions and among subjects scanned at the same different sites. Here, we show can acquire T 1 , 2 * susceptibility mapping (QSM) information a single acquisition, using multi‐echo (ME) extension second gradient‐echo image MP2RAGE sequence. This combination is called ME, MP2RAGEME. The simultaneous acquisition...
Long-term comorbidities such as cognitive impairment remain prevalent in otherwise effectively treated people living with human immunodeficiency virus (HIV). We investigate the relationship between and brain structure successfully patients using multimodal neuroimaging from Comorbidity Relation to AIDS (COBRA) cohort.Cognitive function, tissue volumes, white matter microstructure were assessed 134 HIV-infected 79 controls. All had suppressed plasma HIV RNA at cohort entry. In addition...
The current study aims to evaluate the neurologic state of perinatally HIV-infected children on combination antiretroviral therapy and attain a better insight into pathogenesis their persistent cognitive deficits.We included between 8 18 years healthy controls matched for age, sex, ethnicity, socioeconomic status. All participants underwent 3.0 T MRI with 3D-T1-weighted, 3D-fluid-attenuated inversion recovery, diffusion-weighted series evaluation cerebral volumes, white matter...
Cortical microinfarcts (CMIs) are a common postmortem finding associated with vascular risk factors, cognitive decline, and dementia. Recently, CMIs identified in vivo on 7 Tesla MRI also proved retraceable 3 MRI.We evaluated population-based cohort of 194 nondemented older people (72-80 years) systolic hypertension. Using case-control design, participants without were compared age, sex, cardiovascular white matter hyperintensity volume.We 23 12 (6%). higher diastolic blood pressure, history...
The spectrum of risk factors for HIV-associated cognitive impairment is likely very broad and includes not only HIV/antiretroviral therapy-specific but also other comorbid conditions. purpose this current study was to explore possible determinants decreased performance.Neuropsychological assessment performed on 103 HIV-1-infected men with suppressed viraemia combination antiretroviral therapy at least 12 months 74 HIV-uninfected highly similar male controls, all aged 45 years. Cognitive...