A5007248689- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Intracranial Aneurysms: Treatment and Complications
- Intracerebral and Subarachnoid Hemorrhage Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Venous Thromboembolism Diagnosis and Management
- Stroke Rehabilitation and Recovery
- Atrial Fibrillation Management and Outcomes
- Spine and Intervertebral Disc Pathology
- Clinical practice guidelines implementation
- Musculoskeletal pain and rehabilitation
- Infectious Diseases and Tuberculosis
- Neurological Disorders and Treatments
- Lipoproteins and Cardiovascular Health
- Neural and Behavioral Psychology Studies
- Genetic Neurodegenerative Diseases
- Pneumonia and Respiratory Infections
- Antibiotics Pharmacokinetics and Efficacy
- Spinal Fractures and Fixation Techniques
- S100 Proteins and Annexins
- Cerebral Venous Sinus Thrombosis
- Neurosurgical Procedures and Complications
- Fetal and Pediatric Neurological Disorders
- Visual perception and processing mechanisms
- Toxoplasma gondii Research Studies
University of Groningen
2010-2022
University Medical Center Groningen
2011-2022
Dialyse Centrum Groningen
2021
Vanderbilt University Medical Center
2018
Medisch Centrum Leeuwarden
2018
University of Amsterdam
2018
Amsterdam UMC Location University of Amsterdam
2018
Jordan University of Science and Technology
2018
Radboud University Nijmegen
2018
Radboud University Medical Center
2018
Moxifloxacin cerebrospinal fluid (CSF) penetration was evaluated by obtaining full plasma and CSF time concentration curves for 4 patients with tuberculous meningitis. The geometric mean ratio of the areas under curve to were 0.82 (range, 0.70-0.94) at 400 mg once per day 0.71 (0.58-0.84) 800 day.
Abstract Mid-level visual processing represents a crucial stage between basic sensory input and higher-level object recognition. The conventional model posits that fundamental qualities like color motion are processed in specialized, retinotopic brain regions (e.g., V4 for color, MT/V5 motion). Using atlas-based lesion-symptom mapping disconnectome maps cohort of 307 ischemic stroke patients, we examined the neuroanatomical correlates underlying eight mid-level qualities. Contrary to...
Preliminary findings suggest that statins may have a neuroprotective effect in patients with acute ischaemic stroke. This study investigated whether on prior statin therapy and treated tissue plasminogen activator (tPA) for stroke better functional outcome than statin-naïve patients.In prospective observational cohort of 476 tPA we the relationship between use at 3 months, occurrence symptomatic intracerebral haemorrhage (SICH) early in-hospital mortality. Ischaemic subtypes were defined...
Prothrombin complex concentrates (PCC) can rapidly normalise prolonged prothrombin time, induced by vitamin K antagonists (VKA). We conducted a multicentre retrospective study to investigate whether reversal of VKA coagulopathy with 4-factor PCC improves the survival patients VKA-related intracerebral haemorrhage as compared plasma.We included 135 consecutive treated either plasma (mainly in Canada) or (The Netherlands and Sweden) for VKA. Data on characteristics were collected. The volume...
An ongoing outbreak of Cryptococcus gattii-caused infections, which emerged on Vancouver Island and the Pacific Northwest, has affected more than 200 islands' residents, whom eight died. While C. gattii infections are rarely described in travelers, we report a case cryptococcosis caused by patient treated with high dose corticosteroids for systemic lupus erythematosus induced autoimmune hemolytic anemia. She acquired disease during visit to one year before onset symptoms. This indicates that...
<h3>Objective:</h3> To investigate the effects of medical vs interventional management on functional outcome in A Randomized Trial Unruptured Brain Arteriovenous Malformations (ARUBA). <h3>Methods:</h3> We used initial results a nonblinded, randomized, controlled, parallel-group trial involving adults ≥18 years age with an unruptured brain arteriovenous malformation (AVM) to compare (MM) or without therapy (IT) impairment, defined by primary death symptomatic stroke causing modified Rankin...
Background and purpose: It is unclear whether pre‐stroke beta‐blockers use may influence stroke outcome. This study evaluates the independent effect of on ischaemic severity 3 months functional Methods: Pre‐stroke was investigated in 1375 patients who had been included two placebo‐controlled trials with lubeluzole. Stroke assessed by either National Institute Health Scale (NIHSS) or European (ESS). A modified Rankin scale (mRS) score >3 at used as measure for poor Results: Two hundred...
Rationale: Orthostatic hypotension is a common clinical problem, but the underlying mechanisms have not been fully delineated. Objective: We describe 2 families, with 4 patients in total, experiencing severe life-threatening orthostatic because of novel cause. Methods and Results: As dopamine β-hydroxylase deficiency, concentrations norepinephrine epinephrine were low. Plasma activity, however, was normal, DBH gene had no mutations. Molecular genetic analysis performed to determine...
The Unruptured Intracranial Aneurysm Treatment Score (UIATS) was built to harmonize the treatment decision making on unruptured intracranial aneurysms. Therefore, it may also function as a predictor of aneurysm progression. In this study, we aimed assess validity UIATS model identify aneurysms at risk growth or rupture during follow-up.We calculated for consecutive series conservatively treated aneurysms, included in our prospectively kept neurovascular database. Computed tomography...
Introduction The efficacy and safety of local intra-arterial (IA) thrombolytics during endovascular thrombectomy (EVT) for large-vessel occlusions is uncertain. We analysed how often IA were administered in the Multicenter Randomized Clinical Trial Endovascular Treatment Acute Ischemic Stroke Netherlands (MR CLEAN) Registry, whether it was associated with improved functional outcome assessed technical outcomes compared EVT without thrombolytics. Methods In this observational study, we...
Patients without a subarachnoid haemorrhage (SAH) on brain CT scan (CT-negative), but lumbar puncture (LP)-proven SAH, are challenging patient category. The optimal diagnostic approach is still matter of debate. Also, there little knowledge the probability finding an underlying vascular lesion.In this observational study, consecutive cohort 94 patients with CT-negative, LP-positive SAH was prospectively collected between 1998 and 2013. yield modalities as well outcome studied. In addition,...
The effect of anesthetic management (general anesthesia [GA], conscious sedation, or local anesthesia) on functional outcome and the role blood pressure during endovascular treatment (EVT) for acute ischemic stroke is under debate. We aimed to determine whether hypotension EVT GA associated with at 90 days.We retrospectively collected data from patients a proximal intracranial occlusion anterior circulation treated GA. primary was distribution modified Rankin Scale days. Hypotension defined...