A5059659054- Particle physics theoretical and experimental studies
- Quantum Chromodynamics and Particle Interactions
- High-Energy Particle Collisions Research
- Nuclear physics research studies
- Nuclear Physics and Applications
- Particle Detector Development and Performance
- X-ray Spectroscopy and Fluorescence Analysis
- Radiation Shielding Materials Analysis
- Advanced NMR Techniques and Applications
- Atomic and Molecular Physics
- Dark Matter and Cosmic Phenomena
- Breast Cancer Treatment Studies
- Atomic and Subatomic Physics Research
- Crystallography and Radiation Phenomena
- Advanced X-ray and CT Imaging
- Electron and X-Ray Spectroscopy Techniques
- Quantum, superfluid, helium dynamics
- Radiation Detection and Scintillator Technologies
- Medical Imaging Techniques and Applications
- Advanced X-ray Imaging Techniques
- Advanced Chemical Physics Studies
- Radiation Therapy and Dosimetry
- X-ray Diffraction in Crystallography
- Computational Physics and Python Applications
- Statistical Methods and Inference
University of Freiburg
2014-2024
University Hospital Bonn
2019-2024
Heinrich Heine University Düsseldorf
2024
Düsseldorf University Hospital
2024
University of Göttingen
2007-2019
The University of Adelaide
2018-2019
Novartis (Switzerland)
2007-2017
Novartis Institutes for BioMedical Research
2008-2017
Firalis (France)
2017
Ludwig-Maximilians-Universität München
2011-2016
Prognostic classification schemes have often been used in medical applications, but rarely subjected to a rigorous examination of their adequacy. For survival data, the statistical methodology assess such consists mainly range ad hoc approaches, and there is an alarming lack commonly accepted standards this field. We review these methods develop measures inaccuracy which may be calculated validation study order usefulness estimated patient-specific probabilities associated with prognostic...
To evaluate the efficacy and safety of secukinumab, a fully human, anti-interleukin (IL)-17A monoclonal antibody, in patients with psoriatic arthritis (PsA).42 active PsA fulfilling ClASsification for Psoriatic ARthritis (CASPAR) criteria were randomly assigned (2:1) to receive two intravenous secukinumab doses (10 mg/kg; n=28) or placebo (n=14) 3 weeks apart. The primary endpoint was proportion American College Rheumatology (ACR) 20 responses at week 6 versus (one-sided p<0.1).Primary...
Batch effects are the systematic non-biological differences between batches (groups) of samples in microarray experiments due to various causes such as sample preparation and hybridization protocols. Previous work focused mainly on development methods for effective batch removal. However, their impact cross-batch prediction performance, which is one most important goals microarray-based applications, has not been addressed. This paper uses a broad selection data sets from Microarray Quality...
The response of psoriasis to antibodies targeting the interleukin (IL)-23/IL-17A pathway suggests a prominent role T-helper type-17 (Th17) cells in this disease. We examined clinical and immunological patterns 100 subjects with moderate-to-severe receiving 3 different intravenous dosing regimens anti-IL-17A antibody secukinumab (1 × mg/kg or 1 10 on Day 1, Days 15 29) placebo phase 2 trial. Baseline biopsies revealed typical features active psoriasis, including epidermal accumulation...
Tabulations are presented of relativistic Hartree–Fock–Slater modified atomic form factors from x=0 to 100 Å−1 for all elements Z=1 Z=100. These represent the Rayleigh scattering amplitudes with good accuracy at energies well above K-shell binding and small momentum transfers therefore should be used instead normal in MeV energy range.
This document presents an interim framework in which the coupling structure of a Higgs-like particle can be studied. After discussing different options and approximations, recommendations on specific benchmark parametrizations to used fit data are given.
A direct measurement of the helicity dependence total photoabsorption cross section on proton was carried out at MAMI (Mainz) in energy range 200<Eγ<800MeV. The experiment used a 4π detection system, circularly polarized tagged photon beam, and frozen spin target. contributions to Gerasimov-Drell-Hearn sum rule forward polarizability γ0 determined from data are 226±5(stat)±12(syst)μb −187±8(stat)±10(syst)×10−6fm4, respectively, for 200<Eγ<800MeV.Received 13 March...
Summary Background Robust evidence regarding medical intervention for symptomatic uncomplicated colonic diverticular disease ( DD ) is sparse. Aim To investigate mesalazine (Salofalk granules) in this setting. Methods In a double‐blind, placebo‐controlled, multicentre, 6‐week trial, patients were randomised to 1000 mg three times daily or placebo. Primary efficacy endpoint was change lower abdominal pain week 4 (baseline defined using score from 7 days pre‐treatment). Results Median with vs....
Abstract This investigation is based on measurements of 60 macerated adult European skulls from the Alexander-Ecker Collection at Anatomy Department University Freiburg. Computer tomographical (CT) and anatomical were compared to assess accuracy CT representation osseous structures. Nine structures examined: optic canal; superior orbital fissure; foramen rotundum; ovale; spinosum; Vesalii (venosum); carotid internal auditory canal, hypoglossal canal. The results show a good even excellent...
Canakinumab is a human anti-interleukin-1β (IL-1β) monoclonal antibody neutralizing IL-1β-mediated pathways. We sought to characterize the molecular response canakinumab and evaluate potential markers of using samples from two pivotal trials in systemic juvenile idiopathic arthritis (SJIA).Gene expression was measured patients with febrile SJIA matched healthy controls by Affymetrix DNA microarrays. Transcriptional assessed gene changes baseline day 3 adapted JIA American College...
This analysis aims at evaluating the impact of multidisciplinary tumor boards on clinical outcome multiple entities, effect specific number and potential differences between entities.By a matched-pair we compared response to treatment, overall survival, relapse or disease free survival progression patients whose cases were discussed in board meeting with not. It was performed registered cancer registry University Bonn diagnosed 2010 2016. After matching process pool 7262 total 454 66...
Dispersion theory of proton Compton scattering is extended to energies up \ensuremath{\sim}1 GeV where excitations higher resonances and nonresonance double-pion photoproduction become important photoabsorption mechanisms. To saturate s-channel dispersion relations, the VPI partial-wave analysis single-pion resonance photocouplings used. Models for asymptotic contributions are constructed. The latter mainly given by ${\mathrm{\ensuremath{\pi}}}^{0}$ \ensuremath{\sigma}(600) exchanges. Being...
To verify the fundamental Gerasimov-Drell-Hearn (GDH) sum rule for first time experimentally, we measured helicity dependent total photoabsorption cross section with circularly polarized real photons and longitudinally nucleons in photon energy range 0.68-1.82 GeV tagged facility at ELSA. The experiment was carried out a 4pi detection system, beam, frozen spin proton target. contribution to GDH this is [49.9+/-2.4(stat)+/-2.2(syst)] microb.